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Erschienen in: memo - Magazine of European Medical Oncology 3/2020

26.05.2020 | original report

Rectal cancer among younger Egyptian patients—clinico-pathological features and oncologic outcomes: A single institution experience

verfasst von: Amir M. Zaid, Engy M. Aboelnaga, MD, Amal Halim, Mohamed Abdelkhalek, Saleh S. Elbalka, Mohamed Zuhdy, Ahmed M. Fareed, Eman M. Ibrahim, Hosam Halim, Islam H. Metwally

Erschienen in: memo - Magazine of European Medical Oncology | Ausgabe 3/2020

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Summary

Our younger rectal carcinoma cases had poorer pathologic criteria but the therapy was the crucial factor affecting their survival. Full course of radiotherapy was crucial for better OS of the younger group (P = 0.014), while chemotherapy was crucial for better DFS/PFS in both the young and old age groups (P = 0.00).
Literatur
1.
Zurück zum Zitat De Felice F, Musio D, Izzo L, Tombolini V. Neoadjuvant chemoradiotherapy for locally advanced rectal cancer: the debate continues. World J Gastrointest Oncol. 2014;6:438–40.CrossRef De Felice F, Musio D, Izzo L, Tombolini V. Neoadjuvant chemoradiotherapy for locally advanced rectal cancer: the debate continues. World J Gastrointest Oncol. 2014;6:438–40.CrossRef
2.
Zurück zum Zitat den Dulk M, Krijnen P, Marijnen CA, Rutten HJ, van de Poll-Franse VL, Putter H, et al. Improved overall survival for patients with rectal cancer since 1990: the effects of TME surgery and pre-operative radiotherapy. Eur J Cancer. 2008;44(12):1710–6.CrossRef den Dulk M, Krijnen P, Marijnen CA, Rutten HJ, van de Poll-Franse VL, Putter H, et al. Improved overall survival for patients with rectal cancer since 1990: the effects of TME surgery and pre-operative radiotherapy. Eur J Cancer. 2008;44(12):1710–6.CrossRef
3.
Zurück zum Zitat Sauer R, Becker H, Hohenberger W, Rodel C, Wittekin C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–40.CrossRef Sauer R, Becker H, Hohenberger W, Rodel C, Wittekin C, Fietkau R, et al. Preoperative versus postoperative chemoradiotherapy for rectal cancer. N Engl J Med. 2004;351:1731–40.CrossRef
4.
Zurück zum Zitat Atkin WS, Cuzick J. Screening for colorectal cancer. Lancet. 1993;341:1667.CrossRef Atkin WS, Cuzick J. Screening for colorectal cancer. Lancet. 1993;341:1667.CrossRef
5.
Zurück zum Zitat Bailey CE, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, et al. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975–2010. JAMA Surg. 2015;150(1):17–22.CrossRef Bailey CE, Hu CY, You YN, Bednarski BK, Rodriguez-Bigas MA, Skibber JM, et al. Increasing disparities in the age-related incidences of colon and rectal cancers in the United States, 1975–2010. JAMA Surg. 2015;150(1):17–22.CrossRef
6.
Zurück zum Zitat O’Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY. Rates of colon and rectal cancers are increasing in young adults. Am Surg. 2003;69:866–72.PubMed O’Connell JB, Maggard MA, Liu JH, Etzioni DA, Livingston EH, Ko CY. Rates of colon and rectal cancers are increasing in young adults. Am Surg. 2003;69:866–72.PubMed
7.
Zurück zum Zitat Meyer JE, Narang T, Schnoll-Sussman FH, Pochapin MB, Christos PL, Sherr DL. Increasing incidence of rectal cancer in patients aged younger than 40 years:an analysis of the surveillance, epidemiology, and end results database. Cancer. 2010;116(18):4354–9.CrossRef Meyer JE, Narang T, Schnoll-Sussman FH, Pochapin MB, Christos PL, Sherr DL. Increasing incidence of rectal cancer in patients aged younger than 40 years:an analysis of the surveillance, epidemiology, and end results database. Cancer. 2010;116(18):4354–9.CrossRef
8.
Zurück zum Zitat Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJ, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer? J Am Coll Surg. 2011;213(3):352–61.CrossRef Davis DM, Marcet JE, Frattini JC, Prather AD, Mateka JJ, Nfonsam VN. Is it time to lower the recommended screening age for colorectal cancer? J Am Coll Surg. 2011;213(3):352–61.CrossRef
9.
Zurück zum Zitat Endreseth BH, Romundstad P, Myrvold HE, McDonald JC. Rectal cancer in the young patient. Dis Colon Rectum. 2006;49(7):993–1001.CrossRef Endreseth BH, Romundstad P, Myrvold HE, McDonald JC. Rectal cancer in the young patient. Dis Colon Rectum. 2006;49(7):993–1001.CrossRef
10.
Zurück zum Zitat Marble K, Banerjee S, Greenwald L. Colorectal carcinoma in young patients. J Surg Oncol. 1992;51:179e182.CrossRef Marble K, Banerjee S, Greenwald L. Colorectal carcinoma in young patients. J Surg Oncol. 1992;51:179e182.CrossRef
11.
Zurück zum Zitat Ganapathi S, Kumar D, Katsoulas N, Melville D, Hodgson S, Finlayson C. Colorectal cancer in the young: trends, characteristics and outcome. Int J Colorectal Dis. 2011;26(7):927–34.CrossRef Ganapathi S, Kumar D, Katsoulas N, Melville D, Hodgson S, Finlayson C. Colorectal cancer in the young: trends, characteristics and outcome. Int J Colorectal Dis. 2011;26(7):927–34.CrossRef
12.
Zurück zum Zitat You YN, Dozois EJ, Boardman LA, Aakre J, Huebner M, Larson DW. Young-onset rectal cancer: presentation, pattern of care and long-term oncologic outcomes compared to a matched older-onset cohort. Ann Surg Oncol. 2011;18(9):2469–76.CrossRef You YN, Dozois EJ, Boardman LA, Aakre J, Huebner M, Larson DW. Young-onset rectal cancer: presentation, pattern of care and long-term oncologic outcomes compared to a matched older-onset cohort. Ann Surg Oncol. 2011;18(9):2469–76.CrossRef
13.
Zurück zum Zitat O’Connell JB, Maggard MA, Livingston EH, Yo CK. Colorectal cancer in the young. Am J Surg. 2004;187:343–8.CrossRef O’Connell JB, Maggard MA, Livingston EH, Yo CK. Colorectal cancer in the young. Am J Surg. 2004;187:343–8.CrossRef
14.
Zurück zum Zitat Quah HM, Joseph R, Schrag D, Shia J, Guillem JG, Paty PB, et al. Young age influences treatment but not outcome of colon cancer. Ann Surg Oncol. 2007;14:2759–65.CrossRef Quah HM, Joseph R, Schrag D, Shia J, Guillem JG, Paty PB, et al. Young age influences treatment but not outcome of colon cancer. Ann Surg Oncol. 2007;14:2759–65.CrossRef
15.
Zurück zum Zitat Metwally IH, Shetiwy M, Elalfy AF, Abouzid A, Saleh SS, Hamdy M. Epidemiology and survival of colon cancer among Egyptians: a retrospective study. J Coloproctol. 2019;39(4):339–45.CrossRef Metwally IH, Shetiwy M, Elalfy AF, Abouzid A, Saleh SS, Hamdy M. Epidemiology and survival of colon cancer among Egyptians: a retrospective study. J Coloproctol. 2019;39(4):339–45.CrossRef
16.
Zurück zum Zitat Georgiou A, Khakoo S, Edwards P, Minchom A, Kouvelakis K, Kalaitzaki E, et al. Outcomes of patients with early onset colorectal cancer treated in a UK specialist cancer center. Cancers. 2019;11(10):E1558.CrossRef Georgiou A, Khakoo S, Edwards P, Minchom A, Kouvelakis K, Kalaitzaki E, et al. Outcomes of patients with early onset colorectal cancer treated in a UK specialist cancer center. Cancers. 2019;11(10):E1558.CrossRef
17.
Zurück zum Zitat Benedix F, Kuester D, Meyer F, Lippert H. Influence of mucinous and signet-ring cell differentiation on epidemiological, histological, molecular biological features, and outcome in patients with colorectal carcinoma. Zentralbl Chir. 2013;138(4):427–33.PubMed Benedix F, Kuester D, Meyer F, Lippert H. Influence of mucinous and signet-ring cell differentiation on epidemiological, histological, molecular biological features, and outcome in patients with colorectal carcinoma. Zentralbl Chir. 2013;138(4):427–33.PubMed
18.
Zurück zum Zitat Kolarich A, George TJ Jr, Hughes SJ, Delitto D, Allegra CJ, Hall WA, et al. Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for Stage II and III disease. Cancer. 2018;124(17):3510–9.CrossRef Kolarich A, George TJ Jr, Hughes SJ, Delitto D, Allegra CJ, Hall WA, et al. Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline-directed treatment for Stage II and III disease. Cancer. 2018;124(17):3510–9.CrossRef
19.
Zurück zum Zitat Keane MG, Johnson GJ. Early diagnosis improves survival in colorectal cancer. Practitioner. 1753;256:15–8. Keane MG, Johnson GJ. Early diagnosis improves survival in colorectal cancer. Practitioner. 1753;256:15–8.
20.
Zurück zum Zitat Orbell J, West NJ. Improving Detection of Colorectal Cancer. Practitioner. 2010;254(1733):17–21.PubMed Orbell J, West NJ. Improving Detection of Colorectal Cancer. Practitioner. 2010;254(1733):17–21.PubMed
21.
Zurück zum Zitat Junginger T, Hermanek P, Oberholzer K, Schmidberger H. Rectal carcinoma: Is too much neoadjuvant therapy performed? proposals for a more selective MRI based indication. Zentralbl Chir. 2006;131(4):275–84.CrossRef Junginger T, Hermanek P, Oberholzer K, Schmidberger H. Rectal carcinoma: Is too much neoadjuvant therapy performed? proposals for a more selective MRI based indication. Zentralbl Chir. 2006;131(4):275–84.CrossRef
22.
Zurück zum Zitat Haroon N, Khan S, Rehman Alvi R. Rectal carcinoma under 40 years of age: seven-year post-treatment follow-up at a tertiary care hospital in Pakistan. J Pak Med Assoc. 2013;63(12):1460–3.PubMed Haroon N, Khan S, Rehman Alvi R. Rectal carcinoma under 40 years of age: seven-year post-treatment follow-up at a tertiary care hospital in Pakistan. J Pak Med Assoc. 2013;63(12):1460–3.PubMed
23.
Zurück zum Zitat Tawadros PS, Paquette IM, Hanly AM, Mellgren AF, Rothenberger DA, Madoff RD. Adenocarcinoma of the rectum in patients under age 40 is increasing: Impact of signet-ring cell histology. Dis Colon Rectum. 2015;58(5):474–8.CrossRef Tawadros PS, Paquette IM, Hanly AM, Mellgren AF, Rothenberger DA, Madoff RD. Adenocarcinoma of the rectum in patients under age 40 is increasing: Impact of signet-ring cell histology. Dis Colon Rectum. 2015;58(5):474–8.CrossRef
24.
Zurück zum Zitat Korphaisarn K, Morris V, Davis JS, Michael J, Overman MJ, Fogelman DR, et al. Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer. 2019;121:505–10.CrossRef Korphaisarn K, Morris V, Davis JS, Michael J, Overman MJ, Fogelman DR, et al. Signet ring cell colorectal cancer: genomic insights into a rare subpopulation of colorectal adenocarcinoma. Br J Cancer. 2019;121:505–10.CrossRef
25.
Zurück zum Zitat Mekenkamp L, Krieken J, Marijnen C, van de Velde C, Nagtegaal I. Pathology review committee and the co-operative clinical investigators. Lymph node retrieval in rectal cancer is dependent on many factors—the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol. 2009;33(10):1547–53.CrossRef Mekenkamp L, Krieken J, Marijnen C, van de Velde C, Nagtegaal I. Pathology review committee and the co-operative clinical investigators. Lymph node retrieval in rectal cancer is dependent on many factors—the role of the tumor, the patient, the surgeon, the radiotherapist, and the pathologist. Am J Surg Pathol. 2009;33(10):1547–53.CrossRef
26.
Zurück zum Zitat Bustamante-Lopez L, Nahas CS, Nahas SC, Ribeiro U Jr, Marques CF, Cotti G, et al. Understanding the factors associated with reduction in the number of lymph nodes in rectal cancer patients treated by neoadjuvant treatment. Int J Colorectal Dis. 2017;32(6):925–7.CrossRef Bustamante-Lopez L, Nahas CS, Nahas SC, Ribeiro U Jr, Marques CF, Cotti G, et al. Understanding the factors associated with reduction in the number of lymph nodes in rectal cancer patients treated by neoadjuvant treatment. Int J Colorectal Dis. 2017;32(6):925–7.CrossRef
28.
Zurück zum Zitat Barreto S, Chaubal G, Talole S, DeSouza A, Suradkar K, Gaikwad V, et al. Rectal cancer in young indians—are these cancers different compared to their older counterparts? Indian J Gastroenterol. 2014;33(2):146–50.CrossRef Barreto S, Chaubal G, Talole S, DeSouza A, Suradkar K, Gaikwad V, et al. Rectal cancer in young indians—are these cancers different compared to their older counterparts? Indian J Gastroenterol. 2014;33(2):146–50.CrossRef
29.
Zurück zum Zitat Carrara A, Mangiola D, Pertile R, Ricci A, Motter M, Ghezzi G, et al. Analysis of risk factors for lymph nodal involvement in early stages of rectal cancer: When can local excision be considered an appropriate treatment? Systematic review and meta-analysis of the literature. Rectal Cancer: Multimodal Treatment Approach. Int J Surg Oncol. 2012;2012:438450.PubMedPubMedCentral Carrara A, Mangiola D, Pertile R, Ricci A, Motter M, Ghezzi G, et al. Analysis of risk factors for lymph nodal involvement in early stages of rectal cancer: When can local excision be considered an appropriate treatment? Systematic review and meta-analysis of the literature. Rectal Cancer: Multimodal Treatment Approach. Int J Surg Oncol. 2012;2012:438450.PubMedPubMedCentral
30.
Zurück zum Zitat Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, et al. Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment. Endosc Int Open. 2017;5(12):E1278–E83.CrossRef Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, et al. Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment. Endosc Int Open. 2017;5(12):E1278–E83.CrossRef
31.
Zurück zum Zitat Maksimović S. Survival rates of patients with mucinous adenocarcinoma of the colorectum. Med Arh. 2007;61(1):26–9.PubMed Maksimović S. Survival rates of patients with mucinous adenocarcinoma of the colorectum. Med Arh. 2007;61(1):26–9.PubMed
32.
Zurück zum Zitat Riihimäki M, Hemminki A, Sundquist J, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6:29765.CrossRef Riihimäki M, Hemminki A, Sundquist J, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6:29765.CrossRef
33.
Zurück zum Zitat Pokharkar A, Bhandare M, Patil P, Mehta S, Engineer R, Avanish P, et al. Young vs. old colorectal cancer in Indian subcontinent: a tertiary care center experience. Indian J Surg Oncol. 2017;8(4):491–8.CrossRef Pokharkar A, Bhandare M, Patil P, Mehta S, Engineer R, Avanish P, et al. Young vs. old colorectal cancer in Indian subcontinent: a tertiary care center experience. Indian J Surg Oncol. 2017;8(4):491–8.CrossRef
34.
Zurück zum Zitat Poles GC, Clark DE, Mayo SW, Beierle EA, Goldfarb M, Kenneth W, et al. Colorectal carcinoma in pediatric patients: a comparison with adult tumors, treatment and outcomes from the national cancer database. Pediatr Surg. 2016;51(7):1061–6.CrossRef Poles GC, Clark DE, Mayo SW, Beierle EA, Goldfarb M, Kenneth W, et al. Colorectal carcinoma in pediatric patients: a comparison with adult tumors, treatment and outcomes from the national cancer database. Pediatr Surg. 2016;51(7):1061–6.CrossRef
35.
Zurück zum Zitat Zhao L, Feng Bao F, Yan J, Liu H, Li T, Chen H, et al. Poor prognosis of young patients with colorectal cancer: a retrospective study. Int J Colorectal Dis. 2017;32((8):1147–56.CrossRef Zhao L, Feng Bao F, Yan J, Liu H, Li T, Chen H, et al. Poor prognosis of young patients with colorectal cancer: a retrospective study. Int J Colorectal Dis. 2017;32((8):1147–56.CrossRef
36.
Zurück zum Zitat Orsini RG, Verhoeven RH, Lemmens VE, Steenbergen LN, de Hingh IH, Nieuwenhuijzen GA, et al. Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease. Eur J Cancer. 2015;51(13):1675–82.CrossRef Orsini RG, Verhoeven RH, Lemmens VE, Steenbergen LN, de Hingh IH, Nieuwenhuijzen GA, et al. Comparable survival for young rectal cancer patients, despite unfavourable morphology and more advanced-stage disease. Eur J Cancer. 2015;51(13):1675–82.CrossRef
37.
Zurück zum Zitat Purim O, Gordon N, Brenner B. Cancer of the colon and rectum: potential effects of sex-age interactions on incidence and outcome. Med Sci Monit. 2013;19:203–9.CrossRef Purim O, Gordon N, Brenner B. Cancer of the colon and rectum: potential effects of sex-age interactions on incidence and outcome. Med Sci Monit. 2013;19:203–9.CrossRef
38.
Zurück zum Zitat Gao J, Shao Y, Wang X, Shan Y. Clinicopathological comparison between young and old patients with rectal cancer controlled clinical trial. Zhonghua Wei Chang Wai Ke Za Zhi. 2008;11(1):54–6.PubMed Gao J, Shao Y, Wang X, Shan Y. Clinicopathological comparison between young and old patients with rectal cancer controlled clinical trial. Zhonghua Wei Chang Wai Ke Za Zhi. 2008;11(1):54–6.PubMed
39.
Zurück zum Zitat Zhang R, Zhao J, Xu J, Chen Y. Long-term outcomes and prognostic factors of young patients with mucinous and signet-ring cell colorectal cancer. Arch Med Sci. 2020;16(2):359–65.CrossRef Zhang R, Zhao J, Xu J, Chen Y. Long-term outcomes and prognostic factors of young patients with mucinous and signet-ring cell colorectal cancer. Arch Med Sci. 2020;16(2):359–65.CrossRef
Metadaten
Titel
Rectal cancer among younger Egyptian patients—clinico-pathological features and oncologic outcomes: A single institution experience
verfasst von
Amir M. Zaid
Engy M. Aboelnaga, MD
Amal Halim
Mohamed Abdelkhalek
Saleh S. Elbalka
Mohamed Zuhdy
Ahmed M. Fareed
Eman M. Ibrahim
Hosam Halim
Islam H. Metwally
Publikationsdatum
26.05.2020
Verlag
Springer Vienna
Erschienen in
memo - Magazine of European Medical Oncology / Ausgabe 3/2020
Print ISSN: 1865-5041
Elektronische ISSN: 1865-5076
DOI
https://doi.org/10.1007/s12254-020-00622-z

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