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Well-Differentiated Liposarcoma of the Oesophagus: Clinicopathological, Immunohistochemical and Array CGH Analysis

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Pathology & Oncology Research

Abstract

Liposarcoma develops extremely rarely in the oesophagus. Microscopically, it exhibits subtle atypia of H&E-stained features. Accordingly, immunohistochemical features and chromosomal alterations are used for its confirmatory diagnosis. However, cytogenetic analysis has not been performed for oesophageal liposarcoma. We studied chromosomal alterations using array comparative genomic hybridization (CGH), as well as endoscopic, radiological, H&E-stained and immunohistochemical features in the oesophageal well-differentiated liposarcoma of a 67-year-old man. Array CGH analysis revealed the presence of high-level amplifications at chromosomal locations 1p12–1q21.2, 12q13.2–12q15 and 12q21.33–12q23.1. At least 29 genes were highly amplified (log2 ratio >2), among which CDK4 and MDM2 were the most highly amplified (log2 ratio >4) and were accepted as major target genes. Moreover, the amplification of AMDHD1, HAL and LTA4H (log2 ratio = 3.153) was a novel finding. This case suggests the presence of a characteristic profile of gene amplification in well-differentiated liposarcoma of the oesophagus. The amplified genes may be of pathogenic importance for primary oesophageal well-differentiated liposarcoma.

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References

  1. Mansour KA, Fritz RC, Jacobs DM, Vellios F (1983) Pedunculated liposarcoma of the esophagus: a first case report. J Thorac Cardiovasc Surg 86:447–450

    PubMed  CAS  Google Scholar 

  2. Boggi U, Viacava P, Naccarato AG, Giulianotti PC, di Candio G, Battolla L, Mosca F (1997) Giant pedunculated liposarcomas of the esophagus: literature review and case report. Hepatogastroenterology 44:398–407

    PubMed  CAS  Google Scholar 

  3. Garcia M, Buitrago E, Bejarano PA, Casillas J (2004) Large esophageal liposarcoma: a case report and review of the literature. Arch Pathol Lab Med 128:922–925

    PubMed  Google Scholar 

  4. Yang B, Shi PZ, Li X, Xu RJ (2006) Well-differentiated liposarcoma of esophagus. Chin Med J Engl 119:438–440

    PubMed  Google Scholar 

  5. Will U, Lorenz P, Urban H, Meyer F (2007) Curative endoscopic resection of huge pedunculated esophageal liposarcoma. Endoscopy 39:E15–E16

    Article  PubMed  Google Scholar 

  6. Xu S, Xu Z, Hou Y, Tan Y (2008) Primary pedunculated giant esophageal liposarcoma: case report. Dysphagia 23:327–330

    Article  PubMed  Google Scholar 

  7. Fletcher CDM, Unni K, Mertens F (2000) World health organization classification of tumours. Pathology and genetics. Tumours of soft tissue and bone. IARC, Lyon, pp 35–46

    Google Scholar 

  8. Dei Tos AP, Doglioni C, Piccinin S et al (2000) Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours. J Pathol 190:531–536

    Article  PubMed  CAS  Google Scholar 

  9. Pedeutour F, Forus A, Coindre JM et al (1999) Structure of the supernumerary ring and giant rod chromosomes in adipose tissue tumors. Genes Chromosom Cancer 24:30–41

    Article  PubMed  CAS  Google Scholar 

  10. Persson F, Olofsson A, Sjögren H, Chebbo N, Nilsson B, Stenman G, Aman P (2008) Characterization of the 12q amplicons by high-resolution, oligonucleotide array CGH and expression analyses of a novel liposarcoma cell line. Cancer Lett 260:37–47

    Article  PubMed  CAS  Google Scholar 

  11. Fritz B, Schubert F, Wrobel G et al (2002) Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcoma. Cancer Res 62:2993–2998

    PubMed  CAS  Google Scholar 

  12. Assie G, Guillaud-Bataille M, Ragazzon B, Bertagna X, Bertherat J, Clauser E (2010) The pathophysiology, diagnosis and prognosis of adrenocortical tumors revisited by transcriptome analyses. Trends Endocrinol Metab 21:325–334

    Article  PubMed  CAS  Google Scholar 

  13. Aleman G, Ortíz V, Langley E, Tovar AR, Torres N (2005) Regulation by glucagon of the rat histidase gene promoter in cultured rat hepatocytes and human hepatoblastoma cells. Am J Physiol Endocrinol Metab 289:E172–179

    Article  PubMed  CAS  Google Scholar 

  14. Via M, De Giacomo A, Corvol H et al (2010) Role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clin Exp Allergy 40:482–589

    Google Scholar 

  15. Ishii K, Zaitsu M, Yonemitsu N, Kan Y, Hamasaki Y, Matsuo M (2009) 5-5-lipoxygenase pathway promotes cell proliferation in human glioma cell lines. Clin Neuropathol 28:445–452

    PubMed  CAS  Google Scholar 

  16. Kubbutat MH, Jones SN, Vousden KH (1997) Regulation of p53 stability by Mdm2. Nature 387:299–303

    Article  PubMed  CAS  Google Scholar 

  17. Shangary S, Wang S (2008) Targeting the MDM2-p53 interaction for cancer therapy. Clin Cancer Res 14:5318–5324

    Article  PubMed  CAS  Google Scholar 

  18. Sherr CJ (1996) Cancer cell cycles. Science 274:1672–1677

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

This work was supported by the Seoul National University Boramae Hospital Grant.

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Correspondence to Mee Soo Chang.

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Myung, J.K. and Jeong, J.B. contributed equally to this study.

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Myung, J.K., Jeong, J.B., Han, D. et al. Well-Differentiated Liposarcoma of the Oesophagus: Clinicopathological, Immunohistochemical and Array CGH Analysis. Pathol. Oncol. Res. 17, 415–420 (2011). https://doi.org/10.1007/s12253-010-9322-2

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  • DOI: https://doi.org/10.1007/s12253-010-9322-2

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