Abstract
To study the clinical characters, the outcomes of treatments and the factors affecting treatment results of adenoid cystic carcinomas at Shahid Sadoughi Hospital and Shahid Ramazanzadeh radiotherapy center, Yazd, Iran. The clinical data of 31 patients with adenoid cystic carcinoma of any anatomic site diagnosed over an 8 year period (2004–2012), were investigated retrospectively. Data regarding patients’ characteristics, pathological features and follow-up were obtained from patients records. Survival rate, local recurrence and distant metastasis were analyzed using Kaplan–Meier method. Prognosis factors were analyzed by Log-rank test and Cox regression. The study included31 patients with adenoid cystic carcinoma. The mean age at presentation was 50.2 ± 24.8 years. There were 11 (35.5 %) males and 20 (64.5 %) females with a female predilection (M:F = 0.55:1). Parotid gland was the most common site (8/31, 25.7 %) followed by submandibular gland (7/31, 22.6 %). Perineural invasion was detected in 67.7 % of the cases. Positive surgical status was reported in 48.4 % of the specimens. Metastasis was detected in 25.8 % of the patients and the most common site of distant metastasis was lung. Overall survival rates at 2, 5, and 7 years were 95, 75, and 57 % respectively. Margin status showed significant effect on survival (P value = 0.01). Positive surgical margin is an important factor affecting the prognosis of the patients with adenoid cystic carcinoma. Surgery with negative surgical margin is the first choice of treatment for the patients with adenoid cystic carcinoma. Our findings show that the prognosis of patients with adenoid cystic carcinoma in our center is fair.
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References
Wallace Eveson J, Nagao T (2009) Diseases of the salivary glands. In: Barnes L (ed) Surgical pathology of the head and neck, vol 1, 3rd edn. Informa Healthcare, New York, pp 552–557
Gondivkar SM, Gadbail AR, Chole R, Parikh RV (2011) Adenoid cystic carcinoma: a rare clinical entity and literature review. Oral Oncol 47:231–236
Zhao C, Liu J-Z, Wang S-C (2013) Adenoid cystic carcinoma in the maxillary gingiva: a case report and immunohistochemical study. Cancer Biol Med. 10(1):52–54
Favia G, Maiorano E, Orsini G, Piattelli A (2000) Central (intraosseous) adenoid cystic carcinoma of the mandible: report of a case with periapical involvement. J Endod 26:760–763
Da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, de Almeida OP, Kowalski LP (2006) Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol 42(2):139–146
Triantafillidou K, Dimitrakopoulos J, Iordanidis F, Koufogiannis D (2006) Management of adenoid cystic carcinoma of minor salivary glands. J Oral Maxillofac Surg 64(7):1114–1120
van Weert S, Bloemena E, van der Waal I, de Bree R, Rietveld DHF, Kuik JD, René Leemans C (2013) Adenoid cystic carcinoma of the head and neck: a single-center analysis of 105 consecutive cases over a 30-year period. Oral Oncol 49:824–829
Kumar AN, Harish M, Alavi YA, Mallikarjuna R (2013) Adenoid cystic carcinoma of buccal mucosa BMJ Case Rep. doi: 10.1136/bcr-2013-009770
Lloyd S, Yu JB, Wilson LD, Decker RH (2011) Determinants and patterns of survival in adenoid cystic carcinoma of the head and neck, including an analysis of adjuvant radiation therapy. Am J Clin Oncol 34(1):76–81
Barnes L, Eveson JW, Reichart P et al (2005) World Health Organization classification of tumors: pathology and genetics. IARC, Lyon
Amit M, Binenbaum Y, Sharma K, Naomi DR, Ilana R, Abib A, Miles B, Yang X, Lei D, Kristine B, Christian G, Thomas M, Klaus-Dietrich W, Fliss D, Eckardt AM, Chiara C, Sesenna E, Frank P, Patel S, Gil Z (2013) Analysis of failure in patients with adenoid cystic carcinoma of the head and neck an international collaborative study. Head Neck. 36(7):998–1004
Zhou Q, Chang H, Zhang H, Han Y, Liu H (2012) Increased numbers of P63-positive/CD117-positive cells in advanced adenoid cystic carcinoma give a poorer prognosis. Diagn Pathol 7:119
Ellington CL, Goodman M, Kono SA et al (2012) Adenoid cystic carcinoma of the head and neck. Incidence and survival trends based on 1973–2007 surveillance, epidemiology, and end results data. Cancer 118(18):4444–4451
Gomez DR, Hoppe BS, Wolden SL et al (2008) Outcomes and prognostic variables in adenoid cystic carcinoma of the head and neck: a recent experience. Int J Radiat Oncol Biol Phys. 70:1365–1372
Sengupta S, Roychowdhury A, Bandyopadhyay A (2013) Adenoid cystic carcinoma on the dorsum of the tongue. J Oral Maxillofac Pathol 17(1):98–100
Oplatek A, Ozer E, Agrawal A, Bapna S, Schuller DE (2010) Patterns of recurrence and survival of head and neck adenoid cystic carcinoma after definitive resection. Laryngoscope 120(1):65–70
Bhayani MK, Yener M, El-Naggar A, Garden A, Hanna EY, Weber RS, Kupferman ME (2012) Prognosis and risk factors for early-stage adenoid cystic carcinoma of the major salivary glands. Cancer 118(1):2872–2878
Gao M, Hao Y, Huang MX, Ma DQ, Luo HY, Gao Y, Peng X, Yu GY (2013) Clinicopathological study of distant metastases of salivary adenoid cystic carcinoma. Int J Oral Maxillofac Surg 42:923–928
Rapidis AD, Givalos N, Gakiopoulou H et al (2005) Adenoid cystic carcinoma of the head and neck: clinicopathological analysis of 23 patients and review of the literature. Oral Oncol 41(3):328–335
Ciccolallo L, Licitra L, Cantú G, Gatta G (2009) Survival from salivary glands adenoid cystic carcinoma in European populations. Oral Oncol 45(8):669–674
Jones AS, Hamilton JW, Rowley H, Husband D, Helliwell TR (1997) Adenoid cystic carcinoma of the head and neck. Clin Otolaryngol Allied Sci 8(5):434–443
Elkholti Y, Cosmidis A, Ardiet JM, Laffay L, De Bari B (2013) Adenoid cystic carcinoma of the nasopharynx: a case report and a discussion about prognostic factors and the role of local treatments. Tumori 99(2):55e–60e
Gensheimer MF, Rainey DD, James L, Laramore JJ, Jian-Amadi GE, Chow A, Laura QM et al (2013) Neutron radiotherapy for adenoid cystic carcinoma of the lacrimal gland. Ophthalm Plast Reconstr Surg 29(4):256–260
Martínez-Rodríguez N, Leco-Berrocal I, Rubio-Alonso L, Arias-Irimia O, Martínez-González JM (2011) Epidemiology and treatment of adenoid cystic carcinoma of the minor salivary glands: a meta-analytic study. Med Oral Patol Oral Cir Bucal. 1(16):e884–e889
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The authors are indebted to Shahid Sadoughi University of medical Sciences, Yazd-Iran for cooperation and financial support in this study.
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Binesh, F., Akhavan, A., Masumi, O. et al. Clinicopathological Review and Survival Characteristics of Adenoid Cystic Carcinoma. Indian J Otolaryngol Head Neck Surg 67 (Suppl 1), 62–66 (2015). https://doi.org/10.1007/s12070-014-0755-x
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DOI: https://doi.org/10.1007/s12070-014-0755-x