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Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents

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Abstract

A series of novel ammonium derivatives were synthesized and examined for their antimicrobial efficacy. Comparison of antimicrobial spectrum revealed that compounds 9, 11, 16 and 23 had strong potential against pathogens in vitro. Cytotoxicity results showed compound 9 to be least toxic, it is non-toxic to A549 and U87 cells in MTT assay and exhibits marginal toxicity (15–20%) to human erythrocytes at a concentration of 1000 μg/ml as compared to 100% lysis of cells by 31.25 μg/ml of the standard drug amphotericin B. This compound has MIC values in the range of 1.95–31.25 μg/disc in DDA against different pathogens and may considered to be an important lead antimicrobial molecule for further exploration.

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Authors and Affiliations

  1. Department of Chemistry, University of Delhi, Delhi, 110 007, India

    SHILPI GUPTA, ABHA KATHURIA, SWETA SHARMA, VIRINDER S PARMAR, ANJALI GUPTA & SUNIL K SHARMA

  2. Institute of Genomics and Integrative Biology, Delhi University Campus, Mall Road, Delhi, 110 007, India

    SEEMA SINGH, MANISH KUMAR, RAM KUMAR, BHARAT SINGH & GAINDA L SHARMA

  3. Department of Biotechnology, Pune University, Pune, 411 007, India

    SEEMA SINGH

  4. Katholieke Universiteit Leuven (K.U.Leuven), Celestijnenlaan 200F, 3001, Leuven, Belgium

    SWETA SHARMA & ERIK VAN DER EYCKEN

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  1. SHILPI GUPTA
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Correspondence to GAINDA L SHARMA or SUNIL K SHARMA.

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GUPTA, S., SINGH, S., KATHURIA, A. et al. Ammonium derivatives of chromenones and quinolinones as lead antimicrobial agents. J Chem Sci 124, 437–449 (2012). https://doi.org/10.1007/s12039-011-0147-7

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  • DOI: https://doi.org/10.1007/s12039-011-0147-7

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