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Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy

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Abstract

Several studies have demonstrated an imbalance between free radicals and the antioxidative system in individuals with thyroid dysfunction. However, oxidative stress has not been evaluated in patients with thyroidectomy and thyroparathyroidectomy, who are under replacement therapy. The objective of this study was to evaluate the oxidative stress using malondialdehyde, nitric oxide, and catalase levels in patients with thyroidectomy and thyroparathyroidectomy. Nineteen patients with thyroidectomy, 20 patients with thyroparathyroidectomy, and 20 controls with no history of thyroid or parathyroid disease or surgery were included in the study. Serum malondialdehyde, nitric oxide, and catalase levels were examined. Levels of nitric oxide and malondialdehyde were elevated, and catalase levels decreased in patients with thyroidectomy and thyroparathyroidectomy compared with controls (p value for all the parameters: p < 0.001). Free tetraiodothyronine was a potential predictor of malondialdehyde in the patient groups (p: 0.002). Catalase was negatively correlated with nitric oxide (p < 0.01) and malondialdehyde (p < 0.01). The results of the current study demonstrated that oxidative stress increased in patients with thyroidectomy and thyroparathyroidectomy despite the application of replacement therapies.

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References

  1. D.B. Menzal, The toxicity of air pollution in experimental animals and humans: the role of oxidative stress. Toxicol. Lett. 269, 72–77 (1994)

    Google Scholar 

  2. O.H. El-Habit, H.N. Saada, K.S. Azab, M. Abdel-Rahman, D.F. El-Malah, The modifying effect of beta-carotene on gamma radiation-induced elevation of oxidative reactions and genotoxicity in male rats. Mutat. Res. 466, 179–186 (2000)

    Article  CAS  PubMed  Google Scholar 

  3. C. Demir, H. Demir, R. Esen, M. Atmaca, E. Tagdemir, Erythrocyte catalase and carbonic anhydrase activities in acute leukemias. Asian Pac. J. Cancer Prev. 11, 247–250 (2010)

    PubMed  Google Scholar 

  4. G. Vitale, S. Salvioli, C. Franceschi, Oxidative stress and the ageing endocrine system. Nat. Rev. Endocrinol. 9, 228–240 (2013)

    Article  CAS  PubMed  Google Scholar 

  5. Y. Song, N. Driessens, M. Costa, X. De Deken, V. Detours, B. Corvilain, C. Maenhaut, F. Miot, J. Van Sande, M.C. Many, J.E. Dumont, Roles of hydrogen peroxide in thyroid physiology and disease. J. Clin. Endocrinol. Metab. 92, 3764–3773 (2007)

    Article  CAS  PubMed  Google Scholar 

  6. K. Komosinska-Vassev, K. Olczyk, E.J. Kucharz, C. Marcisz, K. Winsz-Szczotka, A. Kotulska, Free radical activity and antioxidant defense mechanisms in patients with hyperthyroidism due to Graves’ disease during therapy. Clin. Chim. Acta 300, 107–117 (2000)

    Article  CAS  PubMed  Google Scholar 

  7. M. Zarković, The role of oxidative stress on the pathogenesis of graves’ disease. J. Thyroid Res. 2012, 302537 (2012)

    PubMed Central  PubMed  Google Scholar 

  8. V.S. Reddy, S. Gouroju, M.M. Suchitra, V. Suresh, A. Sachan, P.V. Srinivasa Rao, A.R. Bitla, Antioxidant defense in overt and subclinical hypothyroidism. Horm. Metab. Res. 45, 754–758 (2013)

    Article  CAS  PubMed  Google Scholar 

  9. A. Haribabu, V.S. Reddy, C.H. Pallavi, A.R. Bitla, A. Sachan, P. Pullaiah, V. Suresh, P.V. Rao, M.M. Suchitra, Evaluation of protein oxidation and its association with lipid peroxidation and thyrotropin levels in overt and subclinical hypothyroidism. Endocrine 44, 152–157 (2013)

    Article  CAS  PubMed  Google Scholar 

  10. M. Aslan, N. Cosar, H. Celik, N. Aksoy, A.C. Dulger, H. Begenik, Y.U. Soyoral, M.E. Kucukoglu, S. Selek, Evaluation of oxidative status in patients with hyperthyroidism. Endocrine 40, 285–289 (2011)

    Article  CAS  PubMed  Google Scholar 

  11. H. Erdamar, H. Demirci, H. Yaman, M.K. Erbil, T. Yakar, B. Sancak, S. Elbeg, G. Biberoğlu, I. Yetkin, The effect of hypothyroidism, hyperthyroidism, and their treatment on parameters of oxidative stress and antioxidant status. Clin. Chem. Lab. Med. 46, 1004–1010 (2008)

    Article  CAS  PubMed  Google Scholar 

  12. T. Pan, M. Zhong, X. Zhong, Y. Zhang, D. Zhu, Levothyroxine replacement therapy with vitamin E supplementation prevents oxidative stress and cognitive deficit in experimental hypothyroidism. Endocrine 43, 434–439 (2013)

    Article  CAS  PubMed  Google Scholar 

  13. P.A. Singer, D.S. Cooper, E.G. Levy et al., Treatment guidelines for patients with hyperthyroidism and hypothyroidism. JAMA 273, 808–812 (1995)

    Article  CAS  PubMed  Google Scholar 

  14. H. Al-Azem, A.A. Khan, Hypoparathyroidism. Best Pract. Res. Clin. Endocrinol. Metab. 26, 517–522 (2012)

    Article  CAS  PubMed  Google Scholar 

  15. J.R. Garber, R.H. Cobin, H. Gharib, J.V. Hennessey, I. Klein, J.I. Mechanick, R. Pessah-Pollack, P.A. Singer, K.A. Woeber, American Association Of Clinical Endocrinologists And American Thyroid Association Taskforce On Hypothyroidism In Adults, Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Thyroid 22, 1200–1235 (2012)

    Article  CAS  PubMed  Google Scholar 

  16. M.C.K. Browning, W.M. Bennet, A.J. Kirkaldy, R.T. Jung, Intra-individual variation of thyroxine, triiodothyronine, and thyrotropin in treated hypothyroid patients: implications for monitoring replacement therapy. Clin. Chem. 34, 696 (1988)

    CAS  PubMed  Google Scholar 

  17. K. Yagi, Assay for blood plasma or serum. Methods Enzymol. 105, 328–333 (1984)

    Article  CAS  PubMed  Google Scholar 

  18. H. Aebi, Catalase. InVitro. Methods Enzymol. 105, 121–126 (1984)

    Article  CAS  PubMed  Google Scholar 

  19. F. Lyall, A. Young, I.A. Greer, Nitric oxide concentrations are ıncreased in the fetoplacental circulation in preeclampsia. Am. J. Obstet. Gynecol. 173, 714–718 (1995)

    Article  CAS  PubMed  Google Scholar 

  20. P.R. Larsen, T.F. Davies, M. Schlumberger, I.D. Hay, in “10,” in Williams Textbook of Endocrinology, ed. by H.M. Kronenberg, S. Melmed, K.S. Polonsky, P.R. Larsen (Saunders Elsevier, Philadelphia, 2008), pp. 299–332

    Google Scholar 

  21. I. Villanueva, C. Alva-Sánchez, J. Pacheco-Rosado, The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid. Med. Cell. Longev. 2013, 218145 (2013)

    PubMed Central  CAS  PubMed  Google Scholar 

  22. L. Oziol, P. Faure, N. Bertrand, P. Chomard, Inhibition of in vitro macrophage-induced low density lipoprotein oxidation by thyroid compounds. J. Endocrinol. 177, 137–146 (2003)

    Article  CAS  PubMed  Google Scholar 

  23. J. Bednarek, H. Wysocki, J. Sowinski, Oxidation products and antioxidant markers in plasma of patients with Graves’ disease and toxic multinodular goiter: effect of methimazole treatment. Free Radic. Res. 38, 659–664 (2004)

    Article  CAS  PubMed  Google Scholar 

  24. D. Wang, J.F. Feng, P. Zeng, Y.H. Yang, J. Luo, Y.W. Yang, Total oxidant/antioxidant status in sera of patients with thyroid cancers. Endocr. Relat. Cancer 18, 773–782 (2011)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  25. A. Nakai, A. Oya, H. Kobe et al., Changes in maternal lipid peroxidation levels and antioxidant enzymatic activities before and after delivery. J. Nippon Med. Sch. 67, 434–439 (2000)

    Article  CAS  PubMed  Google Scholar 

  26. G. Baskol, H. Atmaca, F. Tanriverdi, M. Baskol, D. Kocer, F. Bayram, Oxidative stress and enzymatic antioxidant status in patients with hypothyroidism before and after treatment. Exp. Clin. Endocrinol. Diabetes 115, 522–526 (2007)

    Article  CAS  PubMed  Google Scholar 

  27. J. Bednarek, H. Wysocki, J. Sowinski, Oxidation products and antioxidant markers in plasma of patients with Graves’ disease and toxic multinodular goiter: effect of methimazole treatment. Free Radic. Res. 38, 659–664 (2004)

    Article  CAS  PubMed  Google Scholar 

  28. S.K. Choudhari, M. Chaudhary, S. Bagde, A.R. Gadbail, V. Joshi, Nitric oxide and cancer: a review. World J. Surg. Oncol. 30, 111–118 (2013)

    Google Scholar 

  29. K. Ojamaa, A. Kenessey, I. Klein, Thyroid hormone regulation of phospholamban phosphorylation in the rat heart. Endocrinology 141, 2139–2144 (2000)

    CAS  PubMed  Google Scholar 

  30. A.B. Engin, A. Sepici-Dincel, I.I. Gonul, A. Engin, Oxidative stress-induced endothelial cell damage in thyroidectomized rat. Exp. Toxicol. Pathol. 64, 481–485 (2012)

    Article  CAS  PubMed  Google Scholar 

  31. S. Taddei, N. Caraccio, A. Virdis, A. Dardano, D. Versari, L. Ghiadoni, A. Salvetti, E. Ferrannini, F. Monzani, Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy. J. Clin. Endocrinol. Metab. 88, 3731–3737 (2003)

    Article  CAS  PubMed  Google Scholar 

  32. R.M. McAllister, I. Albarracin, E.M. Price, T.K. Smith, J.R. Turk, K.D. Wyatt, Thyroid status and nitric oxide in rat arterial vessels. J. Endocrinol. 185, 111–119 (2005)

    Article  CAS  PubMed  Google Scholar 

  33. B. Tejovathi, M.M. Suchitra, V. Suresh, V.S. Reddy, A. Sachan, P.V. Srinivas Rao, A.R. Bitla, Association of lipid peroxidation with endothelial dysfunction in patients with overt hypothyroidism. Exp. Clin. Endocrinol. Diabetes 121, 306–309 (2013)

    Article  CAS  PubMed  Google Scholar 

  34. T. Matsunami, Y. Sato, T. Sato, S. Ariga, T. Shimomura, M. Yukawa, Oxidative stress and gene expression of antioxidant enzymes in the streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. Int. J. Clin. Exp. Pathol. 30, 177–188 (2009)

    Google Scholar 

  35. M.M. Duarte, R.N. Moresco, T. Duarte, A. Santi, M.D. Bagatini, I.B. Da Cruz, M.R. Schetinger, V.L. Loro, Oxidative stress in hypercholesterolemia and its association with Ala16Val superoxide dismutase gene polymorphism. Clin. Biochem. 43, 1118–1123 (2010)

    Article  CAS  PubMed  Google Scholar 

  36. S.D. Kittur, J.W. Hoppener, S.E. Antonarakis, J.D. Daniels, D.A. Meyers, N.E. Maestri, M. Jansen, R.G. Korneluk, B.D. Nelkinİ, H.H. Kazazian Jr, Linkage map of the short arm of human chromosome 11: location of the genes for catalase, calcitonin, and insulin-like growth factor II. Proc. Natl. Acad. Sci. USA 82, 5064–5067 (1985)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  37. M. Tanaka, K. Tokunaga, T. Maruyama, M. Otagiri, Y. Tominaga, K. Itoh, K. Matsushita, H. Komaba, M. Fukagawa, Parathyroidectomy markedly reduces oxidative stress in a patient with primary hyperparathyroidism. Ther. Apher. Dial. 15, 38–41 (2011)

    Article  PubMed  Google Scholar 

  38. S.M. Chen, T.K. Young, Effect of parathyroid hormone on antioxidant enzyme activity and lipid peroxidation of erythrocytes in five-sixths nephrectomized rats. Nephron 73, 235–242 (1996)

    Article  CAS  PubMed  Google Scholar 

  39. K. Hamden, S. Carreau, K. Jamoussi, S. Miladi, S. Lajmi, D. Aloulou, F. Ayadi, A. Elfeki, 1Alpha,25 dihydroxyvitamin D3: therapeutic and preventive effects against oxidative stress, hepatic, pancreatic and renal injury in alloxan-induced diabetes in rats. J. Nutr. Sci. Vitaminol (Tokyo) 55, 215–222 (2009)

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Internal Medicine, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

    Murat Kaçmaz

  2. Department of Endocrinology and Metabolism, Faculty of Medicine, Yuzuncu Yil University, Van, Turkey

    Murat Atmaca

  3. Division of Biochemistry, Department of Chemistry, Faculty of Science, Yuzuncu Yil University, Van, Turkey

    Ayşe Arslan & Halit Demir

  4. Department of Internal Medicine, Van Education and Research Hospital, Van, Turkey

    Mehmet Fatih Özbay

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  1. Murat Kaçmaz
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Correspondence to Murat Atmaca.

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Kaçmaz, M., Atmaca, M., Arslan, A. et al. Oxidative stress in patients with thyroidectomy and thyroparathyroidectomy under replacement therapy. Endocrine 48, 227–232 (2015). https://doi.org/10.1007/s12020-014-0270-6

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  • DOI: https://doi.org/10.1007/s12020-014-0270-6

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