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Serum heart type fatty acid binding protein levels in metabolic syndrome

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Abstract

Heart type fatty acid binding protein (H-FABP) is a major cytoplasmic low-molecular weight protein and released into the circulation when the myocardium is injured. Previous studies have demonstrated that H-FABP is closely associated with acute coronary syndrome, hypertrophic and dilated cardiomyopathy, heart failure, stroke, obstructive sleep apnea syndrome, pulmonary embolism. The aim of this study was to investigate serum H-FABP value in the patients with metabolic syndrome (MetS). We measured serum H-FABP levels in 55 consecutive patients with MetS, and 73 age-matched control subjects by using a sandwich enzyme-linked immunosorbent assay. Serum H-FABP levels were significantly higher in patients with MetS than in control subjects 18.37 ± 13.0 and 7.9 ± 6.5 ng/ml, respectively, (P < 0.001). Serum H-FABP levels were significantly higher in patients with diabetic MetS than in without diabetic MetS, 24.0 ± 10.2 and 13.9 ± 12.6 ng/ml, respectively, (P: 0,003). There were statistically significant differences between patients without diabetic MetS and control subjects, 13.8 ± 12.6 and 7.9 ± 6.5 ng/ml, respectively, (P = 0.023). Patients with MetS have an increased risk of death from cardiovascular diseases. H-FABP seems to be a marker that will enable the detection of cardiac injury in the early asymptomatic period in patients with MetS.

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Abbreviations

BMI:

Body mass index

CVD:

Cardiovascular disease

HDL-C:

High-density lipoprotein cholesterol

TG:

Triglycerides

CIMT:

Carotis intima-media thickness

H-FABP:

Heart type fatty acid binding protein

CAC:

Coronary artery calcium

MetS:

Metabolic syndrome

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Authors and Affiliations

  1. Department of Internal Medicine, Ankara Education and Research Hospital, Ministry of Health, Ankara, Turkey

    Erdem Akbal

  2. Department of Endocrinology and Metabolism Disease, Dışkapı Y.B. Education and Research Hospital, Ministry of Health, Ankara, Turkey

    Mustafa Özbek & Tuncay Delibaşı

  3. Department of Internal Medicine, Dışkapı Y.B. Education and Research Hospital, Ministry of Health, Ankara, Turkey

    Fahri Güneş, Ömer Akyürek & Kemal Üreten

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  1. Erdem Akbal
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  2. Mustafa Özbek
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  3. Fahri Güneş
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Correspondence to Erdem Akbal.

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Akbal, E., Özbek, M., Güneş, F. et al. Serum heart type fatty acid binding protein levels in metabolic syndrome. Endocr 36, 433–437 (2009). https://doi.org/10.1007/s12020-009-9243-6

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  • DOI: https://doi.org/10.1007/s12020-009-9243-6

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