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Cutting Edge Issues in Autoimmune Gastritis

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Abstract

Autoimmune gastritis is the outcome of a pathological CD4 T cell-mediated autoimmune response directed against the gastric H/K-ATPase. Silent initially, the gastric lesion becomes manifest in humans by the development of megaloblastic pernicious anemia arising from vitamin B12 deficiency. Cutting edge issues in this disease relate to its epidemiology, immunogenetics, a role for Helicobacter pylori as an infective trigger through molecular mimicry, its immunopathogenesis, associated organ-specific autoimmune diseases, laboratory diagnosis, and approaches to curative therapy.

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Authors and Affiliations

  1. Centre for Inflammatory Diseases, Department of Medicine, Southern Clinical School, Monash University, Melbourne, VIC, Australia

    Ban-Hock Toh, James Chan & Tin Kyaw

  2. Department of Immunology, Central and Eastern Clinical School, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, VIC, Australia

    Frank Alderuccio

  3. Monash Institute of Medical Research, 27-31 Wright Street, Clayton, VIC, 3168, Australia

    Ban-Hock Toh

  4. Immunology Laboratory, Healthscope Pathology, Clayton, VIC, Australia

    Ban-Hock Toh, James Chan & Tin Kyaw

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  1. Ban-Hock Toh
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  2. James Chan
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  4. Frank Alderuccio
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Correspondence to Ban-Hock Toh.

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Toh, BH., Chan, J., Kyaw, T. et al. Cutting Edge Issues in Autoimmune Gastritis. Clinic Rev Allerg Immunol 42, 269–278 (2012). https://doi.org/10.1007/s12016-010-8218-y

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