Skip to main content

Advertisement

SpringerLink
Log in

Recent Advances on Pathogenesis and Therapies in Systemic Sclerosis

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

Abstract

Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by extensive fibrotic changes in various organs, including skin and lung. Although the etiology of SSc remains unknown, three major abnormalities, abnormal humoral immunity, microvasculature, and fibroblast dysfunctions are considered to play important roles. Significant progress has been made in understanding the pathogenesis on SSc, and has been also providing clues to the treatment for this disease. This review summarizes recent advances on the pathogenesis and new therapeutic strategy for SSc.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Scalapino K, Arkachaisri T, Lucas M et al (2006) J Rheumatol 33:1004–1013

    PubMed  Google Scholar 

  2. Arnett FC, Howard RF, Tan F et al (1996) Arthritis Rheum 39:1362–1370

    Article  PubMed  CAS  Google Scholar 

  3. Zhou X, Tan FK, Wang N et al (2003) Arthritis Rheum 48:2585–2592

    Article  PubMed  CAS  Google Scholar 

  4. Nietert PJ, Mitchell HC, Bolster MB et al (2006) J Rheumatol 33:263–268

    PubMed  Google Scholar 

  5. Furst DE, Clements PJ (1997) J Rheumatol Suppl 48:53–57

    PubMed  CAS  Google Scholar 

  6. Miyawaki S, Asanuma H, Nishiyama S, Yoshinaga Y (2005) J Rheumatol 32:1488–1494

    PubMed  Google Scholar 

  7. Gelber AC, Pillemer SR, Baum BJ et al (2006) Ann Rheum Dis 65:1028–1032

    Article  PubMed  CAS  Google Scholar 

  8. Baroni SS, Santillo M, Bevilacqua F et al (2006) N Engl J Med 354:2667–2676

    Article  PubMed  CAS  Google Scholar 

  9. Kodera M, Hayakawa I, Komura K et al (2005) J Rheumatol 32:629–636

    PubMed  CAS  Google Scholar 

  10. Tan FK, Arnett FC, Antohi S et al (1999) J Immunol 163:1066–1072

    PubMed  CAS  Google Scholar 

  11. Tan FK, Arnett FC, Reveille JD et al (2000) Arthritis Rheum 43:2464–2471

    Article  PubMed  CAS  Google Scholar 

  12. Sato S, Hayakawa I, Hasegawa M, Fujimoto M, Takehara K (2003) J Invest Dermatol 120:542–547

    Article  PubMed  CAS  Google Scholar 

  13. Fujimoto M, Hamaguchi Y, Yazawa N et al (2004) Clin Exp Immunol 138:534–539

    Article  PubMed  CAS  Google Scholar 

  14. Nishijima C, Hayakawa I, Matsushita T et al (2004) Clin Exp Immunol 138:357–363

    Article  PubMed  CAS  Google Scholar 

  15. Henault J, Robitaille G, Senecal JL, Raymond Y (2006) Arthritis Rheum 54:963–973

    Article  PubMed  CAS  Google Scholar 

  16. Ferreira AM, Takagawa S, Fresco R et al (2006) J Invest Dermatol 126:1900–1908

    Article  PubMed  CAS  Google Scholar 

  17. Matsushita T, Hasegawa M, Hamaguchi Y, Takehara K, Sato S (2006) J Rheumatol 33:275–284

    PubMed  CAS  Google Scholar 

  18. Peterlana D, Puccetti A, Caramaschi P et al (2006) Scand J Rheumatol 35:133–137

    Article  PubMed  CAS  Google Scholar 

  19. Carulli MT, Ong VH, Ponticos M et al (2005) Arthritis Rheum 52:3772–3782

    Article  PubMed  CAS  Google Scholar 

  20. Kodera M, Hasegawa M, Komura K et al (2005) Arthritis Rheum 52:2889–2896

    Article  PubMed  CAS  Google Scholar 

  21. Yanaba K, Komura K, Kodera M et al (2006) Ann Rheum Dis 65:124–126

    Article  PubMed  CAS  Google Scholar 

  22. Chizzolini C, Parel Y, De Luca C et al (2003) Arthritis Rheum 48:2593–2604

    Article  PubMed  CAS  Google Scholar 

  23. Lipsky PE (2001) Nat Immunol 2:764–766

    Article  PubMed  CAS  Google Scholar 

  24. Matsushita T, Hasegawa M, Yanaba K et al (2006) Arthritis Rheum 54:192–201

    Article  PubMed  CAS  Google Scholar 

  25. Novobrantseva TI, Majeau GR, Amatucci A et al (2005) J Clin Invest 115:3072–3082

    Article  PubMed  CAS  Google Scholar 

  26. Tedder TF, Poe JC, Fujimoto M, Haas KM, Sato S (2005) Curr Dir Autoimmun 8:55–90

    Article  PubMed  CAS  Google Scholar 

  27. Sato S, Hasegawa M, Fujimoto M, Tedder TF, Takehara K (2000) J Immunol 165:6635–6643

    PubMed  CAS  Google Scholar 

  28. Saito E, Fujimoto M, Hasegawa M et al (2002) J Clin Invest 109:1453–1462

    Article  PubMed  CAS  Google Scholar 

  29. Tsuchiya N, Kuroki K, Fujimoto M et al (2004) Arthritis Rheum 50:4002–4007

    Article  PubMed  CAS  Google Scholar 

  30. Boule MW, Broughton C, Mackay F et al (2004) J Exp Med 199:1631–1640

    Article  PubMed  CAS  Google Scholar 

  31. Chen M, Dittmann A, Kuhn A, Ruzicka T, von Mikecz A (2005) Arthritis Rheum 52:877–884

    Article  PubMed  CAS  Google Scholar 

  32. Ihn H (2005) Curr Rheumatol Rep 7:156–162

    Article  PubMed  CAS  Google Scholar 

  33. Asano Y, Ihn H, Yamane K, Kubo M, Tamaki K (2004) J Clin Invest 113:253–264

    Article  PubMed  CAS  Google Scholar 

  34. Yamane K, Ihn H, Asano Y, Jinnin M, Tamaki K (2003) J Immunol 171:3855–3862

    PubMed  CAS  Google Scholar 

  35. Jinnin M, Ihn H, Yamane K, Tamaki K (2004) J Biol Chem 279:41783–41791

    Article  PubMed  CAS  Google Scholar 

  36. Ibba-Manneschi L, Niissalo S, Milia AF et al (2006) Arthritis Rheum 54:202–213

    Article  PubMed  CAS  Google Scholar 

  37. Kuwana M, Okazaki Y, Yasuoka H, Kawakami Y, Ikeda Y (2004) Lancet 364:603–610

    Article  PubMed  CAS  Google Scholar 

  38. Steen VD, Costantino JP, Shapiro AP, Medsger TA Jr (1990) Ann Intern Med 113:352–357

    PubMed  CAS  Google Scholar 

  39. Boletis JN, Ioannidis JP, Boki KA, Moutsopoulos HM (1999) Lancet 354:569–570

    Article  PubMed  CAS  Google Scholar 

  40. Cherin P, Herson S, Wechsler B et al (1990) Lancet 336:116

    Article  PubMed  CAS  Google Scholar 

  41. Levy Y, Sherer Y, Langevitz P et al (2000) Clin Rheumatol 19:207–211

    Article  PubMed  CAS  Google Scholar 

  42. Asano Y, Ihn H, Asashima N et al (2005) Rheumatology (Oxford) 44:824–826

    Article  CAS  Google Scholar 

  43. Santiago B, Gutierrez-Canas I, Dotor J et al (2005) J Invest Dermatol 125:450–455

    Article  PubMed  CAS  Google Scholar 

  44. Yazawa N, Hamaguchi Y, Poe JC, Tedder TF (2005) Proc Natl Acad Sci U S A 102:15178–15183

    Article  PubMed  CAS  Google Scholar 

  45. Colglazier CL, Sutej PG, O’Rourke KS (2005) J Rheumatol 32:2440–2442

    PubMed  Google Scholar 

  46. Korn JH, Mayes M, Matucci Cerinic M et al (2004) Arthritis Rheum 50:3985–3993

    Article  PubMed  CAS  Google Scholar 

  47. Snyder MJ, Jacobs MR, Grau RG, Wilkes DS, Knox KS (2005) Ann Intern Med 14:802–803

    Google Scholar 

  48. Launay D, Diot E, Pasquier E et al (2006) Presse Med 35:587–592

    PubMed  Google Scholar 

  49. Yamanaka K, Inaba T, Nomura E et al (2005) Cutis 76:373–376

    PubMed  Google Scholar 

  50. Chung L, Fiorentino D (2006) J Am Acad Dermatol 54:880–882

    Article  PubMed  Google Scholar 

  51. Schurawitzki H, Stiglbauer R, Graninger W et al (1990) Radiology 176:755–759

    PubMed  CAS  Google Scholar 

  52. Silver RM, Metcalf JF, Stanley JH, LeRoy EC (1984) Arthritis Rheum 27:1254–1262

    Article  PubMed  CAS  Google Scholar 

  53. Asano Y, Ihn H, Yamane K et al (2001) Arthritis Rheum 44:1363–1369

    Article  PubMed  CAS  Google Scholar 

  54. Yamane K, Ihn H, Kubo M et al (2000) J Rheumatol 27:930–934

    PubMed  CAS  Google Scholar 

  55. Tashkin DP, Elashoff R, Clements PJ et al (2006) N Engl J Med 354:2655–2666

    Article  PubMed  CAS  Google Scholar 

  56. Liossis SN, Bounas A, Andonopoulos AP (2006) Rheumatology (Oxford) 45:1005–1008

    Google Scholar 

  57. Plastiras SC, Kelekis N, Tzelepis GE (2006) N Engl J Med 354:2194–2196

    Article  PubMed  CAS  Google Scholar 

  58. Trad S, Amoura Z, Beigelman C et al (2006) Arthritis Rheum 54:184–191

    Article  PubMed  Google Scholar 

  59. Chang B, Schachna L, White B, Wigley FM, Wise RA (2006) J Rheumatol 33:269–274

    PubMed  Google Scholar 

  60. Hachulla E, Gressin V, Guillevin L et al (2005) Arthritis Rheum 52:3792–3800

    Article  PubMed  Google Scholar 

  61. Joglekar A, Tsai FS, McCloskey DA et al (2006) J Rheumatol 33:61–68

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo Bunkyo-ku, Tokyo, 113-8655, Japan

    Norihito Yazawa & Kunihiko Tamaki

  2. Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan

    Manabu Fujimoto

Authors
  1. Norihito Yazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Manabu Fujimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kunihiko Tamaki
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Norihito Yazawa.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yazawa, N., Fujimoto, M. & Tamaki, K. Recent Advances on Pathogenesis and Therapies in Systemic Sclerosis. Clinic Rev Allerg Immunol 33, 107–112 (2007). https://doi.org/10.1007/s12016-007-8009-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12016-007-8009-2

Keywords

Search

Navigation