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Conjunctival–Limbal Autograft, Amniotic Membrane Transplantation, and Intraoperative Mitomycin C for Primary Pterygium

  • Original Article
  • Published:
Annals of Ophthalmology

Abstract

We evaluated and compared the safety and efficacy of the conjunctival–limbal autograft, amniotic membrane transplantation, and intraoperative application of mitomycin C in 94 patients undergoing primary pterygium surgery and concluded that conjunctival–limbal autografting and amniotic membrane methods were more effective and safer than intraoperative mitomycin C.

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References

  1. Kang DH, See LC, Liav SB, et al. Amniotic membrane graft for primary pterygium comparison with conjunctival autograft and topical mitomycin C treatment. Br J Ophthalmol 2000;84:973–978

    Article  Google Scholar 

  2. Hirst L. Distribution, risk factors, and epidemiology. In Taylor HR (ed.) Pterygium, Vol. 2. The Hague, Netherlands: Kugler; 2000, pp. 15–28

    Google Scholar 

  3. Coroneo MT, Di Girolamo N, Wakefield D. The pathogenesis of pterygia. Curr Opin Ophthalmol 1999;10:282–288

    Article  PubMed  CAS  Google Scholar 

  4. Chowers I, Pe’er J, Zamir E, et al. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology 2001;108:985–988

    Article  PubMed  CAS  Google Scholar 

  5. Oldenburg JB, Garbus J, McDonnell JM, et al. Conjunctival pterygia. Cornea 2000;9:200–204

    Google Scholar 

  6. Chabner BA, Ryan DP, Paz-Ares L, et al. Antineoplastic agents. In Hardman JG, Limbird LE, Gilman AG, eds. Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 10th ed. New York: McGraw-Hill; 2001, 1431 pp

  7. Rubinfeld RS, Pfister RR, Stein RM, et al. Serious complications of topical mitomycin-C after pterygium surgery. Ophthalmology 1992;99:1647–1654

    PubMed  CAS  Google Scholar 

  8. Kim JC, Tseng SCG. Transplantation of preserved human amniotic membrane for surface reconstruction in severely damaged rabbit corneas. Cornea 1995;14:473–484

    Article  PubMed  CAS  Google Scholar 

  9. Cameron ME. Histology of pterygium: an electron microscopik study. Br J Ophthalmol 1983;67:604–605

    Article  PubMed  CAS  Google Scholar 

  10. Jaros PA, De Luise VP. Pingueculae and pterygia. Surv Ophthalmol 1988;33:41–49

    Article  PubMed  CAS  Google Scholar 

  11. Hirst LW, Sebban A, Chant D. Pterygium recurrence time. Ophthalmology 1994;101:755–758

    PubMed  CAS  Google Scholar 

  12. Chen PP, Ariyasu RG, Kaza V, et al. A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium. Am J Ophthalmol 1995;120:151–160

    PubMed  CAS  Google Scholar 

  13. Kenyon KR, Wagoner MD, Hettinger ME. Conjunctival autograft transplantation for advanced and recurrent pterygium. Ophthalmology 1985;92:1461–1470

    PubMed  CAS  Google Scholar 

  14. Sharma A, Gupta A, Ram J. Low-dose intraoperative mitomycin-C versus conjunctival autograft in primary pterygium surgery: long term follow-up. Ophthalmic Surg Lasers 2000;31:301–307

    PubMed  CAS  Google Scholar 

  15. Rao SK, Lekha T, Mukesh BN, et al. Conjunctival–limbal autografts for primary and recurrent pterygia: technique and results. Indian J Ophthalmol 1998;46:203–209

    PubMed  CAS  Google Scholar 

  16. Young AL, Leung GY, Wong AK, et al. A randomised trial comparing 0.02% mitomycin C and limbal conjunctival autograft after excision of primary pterygium. Br J Ophthalmol 2004;88:995–997

    Article  PubMed  CAS  Google Scholar 

  17. Prabhasawat P, Barton K, Burkett G. Comparison of conjunctival autografts, amniotic membrane grafts and primary closure for pterygium excision. Ophthalmology 1997;104:974–985

    PubMed  CAS  Google Scholar 

  18. Fernandes M, Sangwan VS, Bansal AK, et al. Outcome of pterygium surgery: analysis over 14 years. Eye 2005;19:1182–1190

    Article  PubMed  CAS  Google Scholar 

  19. Azuara-Blanco A, Pillai CT, Dua HS. Amniotic membrane transplantation for ocular surface reconstruction. Br J Ophthalmol 1999;83:399–402

    PubMed  CAS  Google Scholar 

  20. Tseng SCG, Prabhasawata P, Lee SH. Amniotic membrane transplantation for conjunctival surface reconstruction. Am J Ophthalmol 1997;124:765–774

    PubMed  CAS  Google Scholar 

  21. Tseng SCG, Dequen L, Xiang MA. Suppression of transforming growth factor beta isoforms, TGF receptor type II and myofibroblast differentiation in cultured human corneal and limbal fibroblast by amniotic membrane matrix. J Cell Physiol 1999;179:325–335

    Article  PubMed  CAS  Google Scholar 

  22. Tseng SCG, Di Pascuale MA, Liu DT, et al. Intraoperative mitomycin C and amniotic membrane transplantation for fornix reconstruction in severe cicatricial ocular surface diseases. Ophthalmology 2005;112:896–903

    Article  PubMed  Google Scholar 

  23. Shimazaki J, Shinozaki N, Tsubota K. Transplantation of amniotic membrane and limbal autograft for patients with recurrent pterygium associated with symblepharon. Br J Ophthalmol 1998;82:235–240

    Article  PubMed  CAS  Google Scholar 

  24. Sato H, Shimazaki J, Shimazaki N, et al. Role of growth factors for ocular surface reconstruction after amniotic membrane transplantation. Invest Ophthalmol Vis Sci 1998;39:428

    Google Scholar 

  25. Allan BD, Short P, Crawford GJ, et al. Pterygium excision with conjunctival autografting: an effective and safe technique. Br J Ophthalmol 1993;77:698–701

    Article  PubMed  CAS  Google Scholar 

  26. Mahar PS. Conjunctival autograft versus topical mitomycin C in treatment of pterygium. Eye 1997;11:790–792

    PubMed  Google Scholar 

  27. Hardten DR, Samuelson TW. Ocular toxicity of mitomycin-C. Int Ophthalmol Clin 1999;39:79–90

    Article  PubMed  CAS  Google Scholar 

  28. Lin CP, Shih MH, Tsai MC. Clinical experiences of infectious scleral ulceration: a complication of pterygium operation. Br J Ophthalmol 1997;81:980–983

    PubMed  CAS  Google Scholar 

  29. Hayasaka S, Noda S, Yamamoto Y, et al. Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium. Am J Ophthalmol 1988;106:715–718

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, Dicle University, Diyarbakir, TR-21280, Turkey

    Ugur Keklikci MD (Assistant Professor of Ophthalmology), Sevin Soker Cakmak MD (Associate Professor of Ophthalmology) & M. Kaan Unlu MD (Professor of Ophthalmology)

  2. Department of Biostatistics, Faculty of Medicine, Dicle University, Diyarbakir, Turkey

    Yusuf Celik PhD (Professor of Biostatistics)

  3. Department of Ophthalmology, Reel Medical Center, Diyarbakir, Turkey

    Bagdagul Bilek MD (Ophthalmologist)

Authors
  1. Ugur Keklikci MD
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  2. Yusuf Celik PhD
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  3. Sevin Soker Cakmak MD
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  4. M. Kaan Unlu MD
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  5. Bagdagul Bilek MD
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Corresponding author

Correspondence to Ugur Keklikci MD.

Additional information

Dr. Keklickci is an Assistant Professor of Ophthalmology, Dr. Cakmak is an Associate Professor of Ophthalmology, and Dr. Unlu is a Professor of Ophthalmology in the Department of Ophthalmology at Dicle University Faculty of Medicine, Diyarbakir, Turkey. Dr. Celik is a Professor of Biostatistics, Department of Biostatistics, Dicle University Faculty of Medicine, Diyarbakir, Turkey. Dr. Bilek is an Ophthalmologist, Department of Ophtalmology, Reel Medical Center, Diyarbakir, Turkey.

The authors have stated that they do not have a significant financial interest or other relationship with any product manufacturer or provider of services discussed in this article. The authors do not discuss the use of off-label products, which includes unlabeled, unapproved, or investigative products or devices.

Based on lower complication rate, the authors concluded that conjunctival–limbal autografting and amniotic membrane methods were more effective and safer than intraoperative mitomycin C.

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Keklikci, U., Celik, Y., Cakmak, S.S. et al. Conjunctival–Limbal Autograft, Amniotic Membrane Transplantation, and Intraoperative Mitomycin C for Primary Pterygium. Ann Ophthalmol 39, 296–301 (2007). https://doi.org/10.1007/s12009-007-9013-0

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  • DOI: https://doi.org/10.1007/s12009-007-9013-0

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