Skip to main content

Advertisement

Log in

State of the Art for Treatment of Vesicovaginal Fistula

  • Lower Urinary Tract Symptoms & Voiding Dysfunction (J Sandhu, Section Editor)
  • Published:
Current Urology Reports Aims and scope Submit manuscript

Abstract

Background

Vesico-vaginal fistulae (VVF) remain the most prevalent genitourinary fistula detrimentally impacting quality of life.

Purpose of the Review

The purpose of this review is to examine relevant literature on management of VVF.

Recent Findings

Obstructed labor is the leading cause of VVF in the developing world with most repairs performed via the transvaginal approach. Conversely, the predominate etiology in industrialized nations is iatrogenic injury with an increasing trend towards abdominal repair via a minimally invasive (laparoscopic and robotic) approach. No studies have compared transvaginal repair to minimally invasive transabdominal approaches. Further, an increasing number of authors have developed algorithms to determine optimum surgical approaches and risk factors for persistent incontinence.

Summary

As surgeons become more facile with laparoscopic and robotic skills, there is a growing trend for minimally invasive surgical management of VVF in developed countries, perhaps widening the disparity gap between developing nations where transvaginal approaches predominate with good success. Further studies are needed to compare transvaginal to minimally invasive transabdominal approaches.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. • Tebeu PM, Fomulu JN, Khaddaj S, de Bernis L, Delvaux T, Rochat CH. Risk factors for obstetric fistula: a clinical review. Int Urogynecol J. 2012;23(4):387–94. A recent meta-analysis of risk factors for VVF in the developing world, many of which are modifiable

    Article  PubMed  Google Scholar 

  2. Tancer ML. Observations on prevention and management of vesicovaginal fistula after total hysterectomy. Surg Gynecol Obstet. 1992;175(6):501–6.

    CAS  PubMed  Google Scholar 

  3. Armenakas NA, Pareek G, Fracchia JA. Iatrogenic bladder perforations: longterm followup of 65 patients. J Am Coll Surg. 2004;198(1):78–82.

    Article  PubMed  Google Scholar 

  4. Raghavaiah NV. Double-dye test to diagnose various types of vaginal fistulas. J Urol. 1974;112(6):811–2.

    Article  CAS  PubMed  Google Scholar 

  5. Redman JF. Female urologic diagnostic techniques. Urol Clin North Am. 1990;17(1):5–8.

    CAS  PubMed  Google Scholar 

  6. Duong TH, Taylor DP, Meeks GR. A multicenter study of vesicovaginal fistula following incidental cystotomy during benign hysterectomies. Int Urogynecol J. 2011;22(8):975–9.

    Article  PubMed  Google Scholar 

  7. Cohen BL, Gousse AE. Current techniques for vesicovaginal fistula repair: surgical pearls to optimize cure rate. Curr Urol Rep. 2007;8(5):413–8.

    Article  PubMed  Google Scholar 

  8. Angioli R, Penalver M, Muzii L, Mendez L, Mirhashemi R, Bellati F, et al. Guidelines of how to manage vesicovaginal fistula. Crit Rev Oncol Hematol. 2003;48(3):295–304.

    Article  PubMed  Google Scholar 

  9. Ahmed S, Holtz SA. Social and economic consequences of obstetric fistula: life changed forever? Int J Gynaecol Obstet. 2007;99(Suppl 1):S10–5.

    Article  PubMed  Google Scholar 

  10. Goodwin WE, Scardino PT. Vesicovaginal and ureterovaginal fistulas: a summary of 25 years of experience. J Urol. 1980;123(3):370–4.

    Article  CAS  PubMed  Google Scholar 

  11. O’Conor VJ Jr. Review of experience with vesicovaginal fistula repair. J Urol. 1980;123(3):367–9.

    Article  PubMed  Google Scholar 

  12. Lee JH, Choi JS, Lee KW, Han JS, Choi PC, Hoh JK. Immediate laparoscopic nontransvesical repair without omental interposition for vesicovaginal fistula developing after total abdominal hysterectomy. JSLS. 2010;14(2):187–91.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Blandy JP, Badenoch DF, Fowler CG, Jenkins BJ, Thomas NW. Early repair of iatrogenic injury to the ureter or bladder after gynecological surgery. J Urol. 1991;146(3):761–5.

    Article  CAS  PubMed  Google Scholar 

  14. Blaivas JG, Heritz DM, Romanzi LJ. Early versus late repair of vesicovaginal fistulas: vaginal and abdominal approaches. J Urol. 1995;153(4):1110–2. discussion 1112–1113

    Article  CAS  PubMed  Google Scholar 

  15. Davits RJ, Miranda SI. Conservative treatment of vesicovaginal fistulas by bladder drainage alone. Br J Urol. 1991;68(2):155–6.

    Article  CAS  PubMed  Google Scholar 

  16. Fouad LS, Chen AH, Santoni CJ, Wehbe C, Pettit PD. Revisiting conservative management of vesicovaginal fistula. J Minim Invasive Gynecol 2016.

  17. Zimmern PE, Hadley HR, Staskin D, Raz S. Genitourinary fistulas: vaginal approach for repair of vesicovaginal fistulas. Clin Obstet Gynaecol. 1985;12(2):403–13.

    CAS  PubMed  Google Scholar 

  18. Stovsky MD, Ignatoff JM, Blum MD, Nanninga JB, O’Conor VJ, Kursh ED. Use of electrocoagulation in the treatment of vesicovaginal fistulas. J Urol. 1994;152(5 Pt 1):1443–4.

    Article  CAS  PubMed  Google Scholar 

  19. Singh R, Schmitt JJ, Knoedler JJ, Occhino JA. Management of a vesicovaginal fistula using holmium laser ablation. Int Urogynecol J. 2016;27(6):969–71.

    Article  PubMed  Google Scholar 

  20. Pettersson S, Hedelin H, Jansson I, Teger-Nilsson AC. Fibrin occlusion of a vesicovaginal fistula. Lancet. 1979;1(8122):933.

    Article  CAS  PubMed  Google Scholar 

  21. Shirvan MK, Alamdari DH, Ghoreifi A. A novel method for iatrogenic vesicovaginal fistula treatment: autologous platelet rich plasma injection and platelet rich fibrin glue interposition. J Urol. 2013;189(6):2125–9.

    Article  PubMed  Google Scholar 

  22. Muto G, D'Urso L, Castelli E, Formiconi A, Bardari F. Cyanoacrylic glue: a minimally invasive nonsurgical first line approach for the treatment of some urinary fistulas. J Urol. 2005;174(6):2239–43.

    Article  CAS  PubMed  Google Scholar 

  23. Russell KW, Robinson RE, Mone MC, Scaife CL. Enterovaginal or vesicovaginal fistula control using a silicone cup. Obstet Gynecol. 2016;128(6):1365–8.

    Article  PubMed  Google Scholar 

  24. Akman RY, Sargin S, Ozdemir G, Yazicioglu A, Cetin S. Vesicovaginal and ureterovaginal fistulas: a review of 39 cases. Int Urol Nephrol. 1999;31(3):321–6.

    Article  CAS  PubMed  Google Scholar 

  25. Sims J. On the treatment of vesicovaginal fistula. Am J Med Sci. 1852;23:59.

    Article  Google Scholar 

  26. Chapple C, Turner-Warwick R. Vesico-vaginal fistula. BJU Int. 2005;95(1):193–214.

    Article  PubMed  Google Scholar 

  27. Raz S, Bregg KJ, Nitti VW, Sussman E. Transvaginal repair of vesicovaginal fistula using a peritoneal flap. J Urol. 1993;150(1):56–9.

    Article  CAS  PubMed  Google Scholar 

  28. Kapoor R, Ansari MS, Singh P, Gupta P, Khurana N, Mandhani A, et al. Management of vesicovaginal fistula: an experience of 52 cases with a rationalized algorithm for choosing the transvaginal or transabdominal approach. Indian J Urol. 2007;23(4):372–6.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Gedik A, Deliktas H, Celik N, Kayan D, Bircan MK. Which surgical technique should be preferred to repair benign, primary vesicovaginal fistulas? Urol J. 2015;12(6):2422–7.

    PubMed  Google Scholar 

  30. Latzko W. Postoperative vesicovaginal fistulas; genesis and therapy. Am J Surg. 1942;58:211–28.

    Article  Google Scholar 

  31. Dorairajan LN, Khattar N, Kumar S, Pal BC. Latzko repair for vesicovaginal fistula revisited in the era of minimal-access surgery. Int Urol Nephrol. 2008;40(2):317–20.

    Article  PubMed  Google Scholar 

  32. • Malde S, Spilotros M, Wilson A, Pakzad M, Hamid R, Ockrim J, Shah PJ, Greenwell T. The uses and outcomes of the Martius fat pad in female urology. World J Urol. 2016. A newer series evaluating efficacy of the Martius interposition graft demonstrating improved outcomes with urethral involvement

  33. Eilber KS, Kavaler E, Rodriguez LV, Rosenblum N, Raz S. Ten-year experience with transvaginal vesicovaginal fistula repair using tissue interposition. J Urol. 2003;169(3):1033–6.

    Article  PubMed  Google Scholar 

  34. •• Lee D, Dillon BE, Zimmern PE. Long-term morbidity of Martius labial fat pad graft in vaginal reconstruction surgery. Urology. 2013;82(6):1261–6. A series of 122 patients undergoing Martius interposition graft of which 20/122 were for VVF. Demonstrated minimal early and delayed morbidity with mean 7-year follow-up

    Article  PubMed  Google Scholar 

  35. Browning A. Lack of value of the Martius fibrofatty graft in obstetric fistula repair. Int J Gynaecol Obstet. 2006;93(1):33–7.

    Article  CAS  PubMed  Google Scholar 

  36. Romics I, Kelemen Z, Fazakas Z. The diagnosis and management of vesicovaginal fistulae. BJU Int. 2002;89(7):764–6.

    Article  CAS  PubMed  Google Scholar 

  37. Shah DK, Vitonis AF, Missmer SA. Association of body mass index and morbidity after abdominal, vaginal, and laparoscopic hysterectomy. Obstet Gynecol. 2015;125(3):589–98.

    Article  PubMed  Google Scholar 

  38. O'Conor VJ, Sokol JK. Vesicovaginal fistula from the standpoint of the urologist. J Urol. 1951;66(4):579–85.

    Article  PubMed  Google Scholar 

  39. Nieboer TE, Johnson N, Lethaby A, Tavender E, Curr E, Garry R, et al. Surgical approach to hysterectomy for benign gynaecological disease. Cochrane Database Syst Rev. 2009;3:CD003677.

    Google Scholar 

  40. Salup RR, Julian TB, Liang MD, Narayanan K, Finegold R. Closure of large postradiation vesicovaginal fistula with rectus abdominis myofascial flap. Urology. 1994;44(1):130–1.

    Article  CAS  PubMed  Google Scholar 

  41. Dutto L, O'Reilly B. Robotic repair of vesico-vaginal fistula with perisigmoid fat flap interposition: state of the art for a challenging case? Int Urogynecol J. 2013;24(12):2029–30.

    Article  CAS  PubMed  Google Scholar 

  42. Ghosh B, Biswal DK, Bera MK, Pal DK. Laparoscopic vesicovaginal fistula repair with limited cystotomy: a rewarding treatment option. J Obstet Gynaecol India. 2016;66(Suppl 1):370–6.

    Article  PubMed  Google Scholar 

  43. Hadzi-Djokic J, Pejcic T, Stamenkovic V, Petrovic M, Acimovic M. Buccal mucosal graft interposition in the treatment of recurrent vesicovaginal fistula: a report on two cases. Taiwan J Obstet Gynecol. 2015;54(6):773–5.

    Article  PubMed  Google Scholar 

  44. Sotelo R, Mariano MB, Garcia-Segui A, Dubois R, Spaliviero M, Keklikian W, et al. Laparoscopic repair of vesicovaginal fistula. J Urol. 2005;173(5):1615–8.

    Article  PubMed  Google Scholar 

  45. von Theobald P, Hamel P, Febbraro W. Laparoscopic repair of a vesicovaginal fistula using an omental J flap. Br J Obstet Gynaecol. 1998;105(11):1216–8.

    Article  Google Scholar 

  46. Nezhat CH, Nezhat F, Nezhat C, Rottenberg H. Laparoscopic repair of a vesicovaginal fistula: a case report. Obstet Gynecol. 1994;83(5 Pt 2):899–901.

    CAS  PubMed  Google Scholar 

  47. •• Miklos JR, Moore RD, Chinthakanan O. Laparoscopic and robotic-assisted vesicovaginal fistula repair: a systematic review of the literature. J Minim Invasive Gynecol. 2015;22(5):727–36. A meta-analysis of recent articles on laparoscopic and robotic VVF repairs demonstrating safety and efficacy of these approaches in the experienced surgeon’s hands. A small increase in success seen with patients having an intraoperative leak test

    Article  PubMed  Google Scholar 

  48. Melamud O, Eichel L, Turbow B, Shanberg A. Laparoscopic vesicovaginal fistula repair with robotic reconstruction. Urology. 2005;65(1):163–6.

    Article  CAS  PubMed  Google Scholar 

  49. •• Ghosh B, Wats V, Pal DK. Comparative analysis of outcome between laparoscopic versus open surgical repair for vesico-vaginal fistula. Obstet Gynecol Sci. 2016;59(6):525–9. A review of patients undergoing laparoscopic VVF repair vs. open and demonstrated reduced morbidity and shorter hospital stay for the laparoscopic cohort

    Article  PubMed  PubMed Central  Google Scholar 

  50. •• Sotelo R, Moros V, Clavijo R, Poulakis V. Robotic repair of vesicovaginal fistula (VVF). BJU Int. 2012;109(9):1416–34. A surgical atlas for VVF repair

    Article  PubMed  Google Scholar 

  51. Javali TD, Katti A, Nagaraj HK. A simplified laparoscopic approach to repair vesicovaginal fistula: the M.S. Ramaiah technique. Urology. 2015;85(3):544–6.

    Article  PubMed  Google Scholar 

  52. Bora GS, Singh S, Mavuduru RS, Devana SK, Kumar S, Mete UK, Singh SK, Mandal AK. Robot-assisted vesicovaginal fistula repair: a safe and feasible technique. Int Urogynecol J. 2016.

  53. •• Kopp DM, Bengtson AM, Tang JH, Chipungu E, Moyo M, Wilkinson J. Use of a postoperative pad test to identify continence status in women after obstetric vesicovaginal fistula repair: a prospective cohort study. BJOG. 2017. A review of 346 patients undergoing VVF repair demonstrating a negative pad test prior to discharge demonstrated a high predictive value of postoperative continence

  54. Barone MA, Frajzyngier V, Ruminjo J, Asiimwe F, Barry TH, Bello A, et al. Determinants of postoperative outcomes of female genital fistula repair surgery. Obstet Gynecol. 2012;120(3):524–31.

    Article  PubMed  PubMed Central  Google Scholar 

  55. •• Bengtson AM, Kopp D, Tang JH, Chipungu E, Moyo M, Wilkinson J. Identifying patients with vesicovaginal fistula at high risk of urinary incontinence after surgery. Obstet Gynecol. 2016;128(5):945–53. A review of 401 women undergoing VVF in Malawi and developed a risk calculation for post-VVF failure. This may potentially be used to refer high-risk women to more experienced surgeons

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Ann Gormley.

Ethics declarations

Conflict of Interest

Rachel A. Moses and E. Ann Gormley each declare no potential conflicts of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Additional information

This article is part of the Topical Collection on Lower Urinary Tract Symptoms & Voiding Dysfunction

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Moses, R.A., Ann Gormley, E. State of the Art for Treatment of Vesicovaginal Fistula. Curr Urol Rep 18, 60 (2017). https://doi.org/10.1007/s11934-017-0708-5

Download citation

  • Published:

  • DOI: https://doi.org/10.1007/s11934-017-0708-5

Keywords

Navigation