Abstract
Purpose of Review
Polyarthritis can have numerous reasons and may thus constitute a challenge for differential diagnosis. One rare potential reason for sterile polyarthritis is underlying pancreatic disease with systemic hyperlipasemia, most often accompanied by painful skin lesions caused by a subcutaneous inflammatory process known as panniculitis. Systematic evidence on pancreatic panniculitis and polyarthritis is limited, particularly regarding its feature as facultative paraneoplasia with underlying intra- or even extra-pancreatic malignancy. Therefore, we will summarize the current knowledge about this orphan disease including epidemiological, pathophysiological, diagnostic, and treatment aspects in the present review.
Recent Findings
Although direct evidence is lacking, it is highly probable that pancreatic polyarthritis and panniculitis are caused by peripheral lipolytic activity of lipase systemically circulating due to benign (e.g., acute or chronic pancreatitis) or malign (e.g., acinar cell carcinoma (ACC) or adenocarcinoma) pancreatic disease. In the latter case, pancreatic polyarthritis and panniculitis are associated with poor outcome.
Summary
Pancreatic polyarthritis and panniculitis should always be included into diagnostic considerations, and once suspected, a thorough work-up to identify the underlying disease has to be performed.
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References
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Leopold SS. Minimally invasive total knee arthroplasty for osteoarthritis. N Engl J Med. 2009;360:1749–58.
Ritchlin CT, Colbert RA, Gladman DD. Psoriatic arthritis. N Engl J Med. 2017;376:957–70.
McInnes IB, Schett G. The pathogenesis of rheumatoid arthritis. N Engl J Med. 2011;365:2205–19.
• Ferri V, Ielpo B, Duran H, Diaz E, Fabra I, Caruso R, et al. Pancreatic disease, panniculitis, polyarthrtitis syndrome successfully treated with total pancreatectomy: case report and literature review. Int J Surg Case Rep. 2016;28:223–6. One of the rare systematic reviews on PPP syndrome.
• Loverdos I, Swan MC, Shekherdimian S, Al-Rasheed AA, Schneider R, Fish JS, et al. A case of pancreatitis, panniculitis and polyarthritis syndrome: elucidating the pathophysiologic mechanisms of a rare condition. J Pediatr Surg Case Rep. 2015;3:223–6. This case report gives valuable pathogenetic insights, as an enrichment of lipase is demonstrated in joint fluid.
•• Zundler S, Erber R, Agaimy A, Hartmann A, Kiesewetter F, Strobel D, et al. Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver—case report and review of literature. BMC Cancer. 2016;16:130. First report of PPP due to pancreatic-type ACC of the liver and systematic review of 131 PP cases.
Majumder S, Chari ST. Chronic pancreatitis. Lancet. 2016;387:1957–66.
Narváez J, Bianchi MM, Santo P, de la Fuente D, Ríos-Rodriguez V, Bolao F, et al. Pancreatitis, panniculitis, and polyarthritis. Semin Arthritis Rheum. 2010;39:417–23.
Naeyaert C, de Clerck F, Wilde VD. Pancreatic panniculitis as a paraneoplastic phenomenon of a pancreatic acinar cell carcinoma. Acta Clin Belg. 2016;71:448–50.
Arbeláez-cortés Á, Vanegas-garcía AL, Restrepo-escobar M, Correa-londoño LA, González-naranjo LA. Polyarthritis and pancreatic panniculitis associated with pancreatic carcinoma: review of the literature. J Clin Rheumatol. 2014;20:433–6.
Dhawan SS, Jimenez-Acosta F, Poppiti RJ, Barkin JS. Subcutaneous fat necrosis associated with pancreatitis: histochemical and electron microscopic findings. Am J Gastroenterol. 1990;85:1025–8.
Borowicz J, Morrison M, Hogan D, Miller R. Subcutaneous fat necrosis/panniculitis and polyarthritis associated with acinar cell carcinoma of the pancreas: a rare presentation of pancreatitis, panniculitis and polyarthritis syndrome. J Drugs Dermatol. 2010;9:1145–50.
Kang DJ, Lee SJ, Choo HJ, Her M, Yoon HK. Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome: MRI features of intraosseous fat necrosis involving the feet and knees. Skelet Radiol. 2017;46:279–85.
Lowery MA, Klimstra DS, Shia J, Yu KH, Allen PJ, Brennan MF, et al. Acinar cell carcinoma of the pancreas: new genetic and treatment insights into a rare malignancy. Oncologist. 2011;16:1714–20.
Riechelmann RP, Hoff PM, Moron RA, da Câmera Lopes LH, Buzaid AC. Acinar cell carcinoma of the pancreas. Int J Gastrointest Cancer. 2003;34:67–72.
Berman B, Conteas C, Smith B, Leong S, Hornbeck L. Fatal pancreatitis presenting with subcutaneous fat necrosis. J Am Acad Dermatol. 1987;17:359–64.
Laureano A, Mestre T, Ricardo L, Rodrigues AM, Cardoso J. Pancreatic panniculitis—a cutaneous manifestation of acute pancreatitis. J Dermatol Case Rep. 2014;8:35–7.
Radin DR, Colletti PM, Forrester DM, Tang WW. Pancreatic acinar cell carcinoma with subcutaneous and intraosseous fat necrosis. Radiology. 1986;158:67–8.
Morita O, Ogose A, Hotta T, Kawashima H, Higuchi T, Suzuki K, et al. Pathological fractures due to intraosseous fat necrosis associated with pancreatitis. Rheumatology. 2003;42:394–7.
Saag KG, Niemann TH, Warner CA, Naides SJ. Subcutaneous pancreatic fat necrosis associated with acute arthritis. J Rheumatol. 1992;19:630–2.
Ferrari R, Wendelboe M, Ford PM, Corbett WE, Anastassiades TP. Pancreatitis arthritis with periarticular fat necrosis. J Rheumatol. 1993;20:1436–7.
Requena L, Requena C. Erythema nodosum. Dermatol Online J. 2002;8:4.
Requena L, Yus ES. Panniculitis. Part I. Mostly septal panniculitis. J Am Acad Dermatol. 2001;45:163–83. 186
Requena L, Sánchez Yus E. Panniculitis. Part II. Mostly lobular panniculitis. J Am Acad Dermatol. 2001;45:325–61. 364
Pujalte GGA, Albano-Aluquin SA. Differential diagnosis of polyarticular arthritis. Am Fam Physician. 2015;92:35–41.
Dieker W, Derer J, Henzler T, Schneider A, Rückert F, Wilhelm TJ, et al. Pancreatitis, panniculitis and polyarthritis (PPP-) syndrome caused by post-pancreatitis pseudocyst with mesenteric fistula. Diagnosis and successful surgical treatment. Case report and review of literature. Int J Surg Case Rep. 2017;31:170–5.
Tenner S, Baillie J, DeWitt J, Vege SS. American College of Gastroenterology. American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol. 2013;108:1400–15. 1416
Forsmark CE. Management of chronic pancreatitis. Gastroenterology. 2013;144:1282–1291.e3.
Kitagami H, Kondo S, Hirano S, Kawakami H, Egawa S, Tanaka M. Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from pancreatic cancer registry of Japan pancreas society. Pancreas. 2007;35:42–6.
Ducreux M, Cuhna AS, Caramella C, Hollebecque A, Burtin P, Goéré D, et al. Cancer of the pancreas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2015;26:v56–68.
Öberg K, Knigge U, Kwekkeboom D, Perren A. Neuroendocrine gastro-entero-pancreatic tumors: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23:vii124–30.
Butturini G, Pisano M, Scarpa A, D’Onofrio M, Auriemma A, Bassi C. Aggressive approach to acinar cell carcinoma of the pancreas: a single-institution experience and a literature review. Langenbeck's Arch Surg. 2011;396:363–9.
Glazer ES, Neill KG, Frakes JM, Coppola D, Hodul PJ, Hoffe SE, et al. Systematic review and case series report of acinar cell carcinoma of the pancreas. Cancer Control. 2016;23:446–54.
Yoshihiro T, Nio K, Tsuchihashi K, Ariyama H, Kohashi K, Tsuruta N, et al. Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: a case report. Mol Clin Oncol. 2017;6:866–70.
Seth AK, Argani P, Campbell KA, Cameron JL, Pawlik TM, Schulick RD, et al. Acinar cell carcinoma of the pancreas: an institutional series of resected patients and review of the current literature. J Gastrointest Surg. 2008;12:1061–7.
Holen KD, Klimstra DS, Hummer A, Gonen M, Conlon K, Brennan M, et al. Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. J Clin Oncol. 2002;20:4673–8.
Banfill KE, Oliphant TJ, Prasad KR. Resolution of pancreatic panniculitis following metastasectomy. Clin Exp Dermatol. 2012;37:440–1.
Riediger C, Mayr M, Berger H, Becker K, Dobritz M, Kleeff J, et al. Transarterial chemoembolization of liver metastases as symptomatic therapy of lipase Hypersecretion syndrome. J Clin Oncol. 2012;30:e209–12.
Lengfeld J, Kneitz H, Goebeler M, Kolb-Mäurer A. Panniculitis due to pancreatic disease. J Dtsch Dermatol Ges. 2015;13:807–9.
Hudson-Peacock MJ, Regnard CF, Farr PM. Liquefying panniculitis associated with acinous carcinoma of the pancreas responding to octreotide. J R Soc Med. 1994;87:361–2.
Durden FM, Variyam E, Chren MM. Fat necrosis with features of erythema nodosum in a patient with metastatic pancreatic carcinoma. Int J Dermatol. 1996;35:39–41.
Bogart MM, Milliken MC, Patterson JW, Padgett JK. Pancreatic panniculitis associated with acinic cell adenocarcinoma: a case report and review of the literature. Cutis. 2007;80:289–94.
Guo ZZ, Huang ZY, Huang LB, Tang CW. Pancreatic panniculitis in acute pancreatitis. J Dig Dis. 2014;15:327–30.
Zhang G, Cao Z, Yang G, Wu W, Zhang T, Zhao Y. Pancreatic panniculitis associated with pancreatic carcinoma. Medicine (Baltimore). 2016 ;95:e4374..
Price-Forbes AN, Filer A, Udeshi UL, Rai A. Progression of imaging in pancreatitis panniculitis polyarthritis (PPP) syndrome. Scand J Rheumatol. 2006;35:72–4.
Karasick D, Schweitzer ME. Case 4: intraosseous fat necrosis associated with pancreatitis. Radiology. 1998;209:521–4.
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Zundler, S., Strobel, D., Manger, B. et al. Pancreatic Panniculitis and Polyarthritis. Curr Rheumatol Rep 19, 62 (2017). https://doi.org/10.1007/s11926-017-0690-4
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DOI: https://doi.org/10.1007/s11926-017-0690-4