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Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes

  • Neuro-oncology (S Nagpal, Section Editor)
  • Published:
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Abstract

The disorders of the central nervous system associated with cancer by remote immune-mediated mechanisms are a heterogeneous group. These disorders encompass the classic paraneoplastic disorders and the recently recognized autoimmune encephalitis associated with antibodies against neuronal cell surface or synaptic proteins that occur with or without cancer association. In the last decade, the new surge of interest in neuronal diseases associated with anti-neuronal antibodies led to the rapid discovery of new forms of disease that have different manifestations and were not previously suspected to be immune mediated. The recognition of these syndromes is important because it may lead to early detection of an underlying malignancy and prompt initiation of treatment, improving chances for a better outcome.

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Authors and Affiliations

  1. Neurology Division, Hospital das Clínicas, University of São Paulo School of Medicine, Sao Paulo, Brazil

    Ronnyson Susano Grativvol, Wagner Cid Palmeira Cavalcante, Luiz Henrique Martins Castro, Ricardo Nitrini & Mateus Mistieri Simabukuro

  2. The State of São Paulo Cancer Institute, Sao Paulo, Brazil

    Mateus Mistieri Simabukuro

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  1. Ronnyson Susano Grativvol
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  2. Wagner Cid Palmeira Cavalcante
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Ronnyson Susano Grativvol declares that he has no conflict of interest.

Wagner Cid Palmeira Cavalcante declares that he has no conflict of interest.

Luiz Henrique Martins Castro declares that he has no conflict of interest.

Ricardo Nitrini has received research funding from FAPESP, has served on advisory boards for Janssen-Cilag and Brazilian Nutricia, has received travel funding and reimbursement from Novartis, serves as an editor for Dementia & Neuropsychologia, serves on the editorial board for Alzheimer’s Disease & Associated Disorders and International Journal of Alzheimer’s Disease, and has served as a guest speaker for Novartis and Danone (Nutricia).

Mateus Mistieri Simabukuro declares that he has no conflict of interest.

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Grativvol, R.S., Cavalcante, W.C.P., Castro, L.H.M. et al. Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes. Curr Oncol Rep 20, 92 (2018). https://doi.org/10.1007/s11912-018-0721-y

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