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Radionuclide Therapy for Neuroendocrine Tumors

  • Gastrointestinal Cancers (J Meyer, Section Editor)
  • Published:
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Abstract

Peptide receptor radionuclide therapy (PRRT) is a form of systemic radiotherapy that allows targeted delivery of radionuclides to tumor cells expressing high levels of somatostatin receptors. The two radiopeptides most commonly used for PRRT, 90Y-DOTATOC and 177Lu-DOTATATE, have been successfully employed for more than a decade for the treatment of advanced neuroendocrine tumors (NETs). Recently, the phase III, randomized NETTER-1 trial has compared 177Lu-DOTATATE versus high-dose octreotide LAR in patients with progressive, metastatic midgut NETs, demonstrating exceptional tolerability and efficacy. This review summarizes recent developments in the field of radionuclide therapy for gastroenteropancreatic and lung NETs and considers possible strategies to further enhance its clinical efficacy.

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Authors and Affiliations

  1. Department of Gastrointestinal Oncology, H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Mauro Cives & Jonathan Strosberg

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  1. Mauro Cives
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  2. Jonathan Strosberg
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Correspondence to Jonathan Strosberg.

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Mauro Cives declares that he has no conflict of interest.

Jonathan Strosberg has received research funding from Novartis and Advanced Accelerator Applications and has performed consultation for Novartis, Pfizer, Genentech, Lexicon, and Ipsen within institutional conflict-of-interest payment guidelines.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Gastrointestinal Cancers

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Cives, M., Strosberg, J. Radionuclide Therapy for Neuroendocrine Tumors. Curr Oncol Rep 19, 9 (2017). https://doi.org/10.1007/s11912-017-0567-8

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