Skip to main content
Log in

Complicated urinary tract infections

  • Published:
Current Infectious Disease Reports Aims and scope Submit manuscript

Abstract

This review highlights recent findings regarding complicated urinary tract infections (UTIs). We review recently published randomized controlled trials, Cochrane reviews, and meta-analyses. Topics covered include new findings on the genetics of acute pyelonephritis, methods to prevent catheter-associated UTI, duration of treatment for catheter-associated UTI, and reimbursement changes for Medicare patients who develop nosocomial UTI in US hospitals. Future studies on complicated UTI are needed to better define this complex disease and its management and to confirm the clinical significance of different prevention strategies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Hooton TM, Stamm WE: Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin North Am 1997, 11:551–581.

    Article  PubMed  CAS  Google Scholar 

  2. Hang L, Frendeus B, Godaly G, Svanborg C: Interleukin-8 receptor knockout mice have subepithelial neutrophil entrapment and renal scarring following acute pyelonephritis. J Infect Dis 2000, 182:1738–1748.

    Article  PubMed  CAS  Google Scholar 

  3. Frendeus B, Godalay G, Hang L, et al.: Interleukin-8 receptor deficiency confers susceptibility to acute pyelonephritis and may have a human counterpart. J Exp Med 2000, 192:881–890.

    Article  PubMed  CAS  Google Scholar 

  4. Hopkins WJ, Uehling DT, Wargowski DS: Evaluation of a familial predisposition to recurrent urinary tract infections in women. Am J Med Genet 1999, 83:422–424.

    Article  PubMed  CAS  Google Scholar 

  5. Lundstedt AC, McCarthy S, Gustafsson CU, et al.: A genetic basis of susceptibility to acute pyelonephritis. PloS ONE 2007, 2:e825.

    Article  PubMed  Google Scholar 

  6. Lundstendt AC, Leijonhufvud I, Ragnarsdottir B, et al.: Inherited susceptibility to acute pyelonephritis: a family study of urinary tract infection. J Infect Dis 2007, 195:1227–1234.

    Article  Google Scholar 

  7. Saint S, Kaufman SR, Rogers MA, et al.: Condom versus indwelling urinary catheters: a randomized trial. J Am Geriatr Soc 2006, 54:1055–1061.

    Article  PubMed  Google Scholar 

  8. Jacobsen SM, Stickler DJ, Mobley HL, Shirtliff ME: Complicated catheter-associated urinary tract infections due to Escherichia coli and Proteus mirabilis. Clin Microb Rev 2008, 21:26–59.

    Article  CAS  Google Scholar 

  9. Laehdevirta J, Tallgren KG, Kuhlbaeck B: System of closed, sterile urinary drainage with indwelling catheter. Duodecim 1963, 79:978–984.

    PubMed  CAS  Google Scholar 

  10. Cornia PB, Amory JK, Fraser S, et al.: Computer based order entry decreases duration of indwelling urinary tract infections in hospitalized patients. Am J Med 2003, 114:404–407.

    Article  PubMed  Google Scholar 

  11. Apisarnthanarak A, Thongphubeth K, Sirinvaravong S, et al.: Effectiveness of multifaceted hospital wide quality improvement programs featuring an intervention to remove unnecessary urinary catheters at the tertiary care center in Thailand. Infect Control Hosp Epidemiol 2007, 28:791–798.

    Article  PubMed  Google Scholar 

  12. Polliack T, Bluvshtein V, Philo O, et al.: Clinical and economical consequences of volume-or time-dependent intermittent catheterization in patients with spinal cord lesions and neuropathic bladder. Spinal Cord 2005, 43:615–619.

    Article  PubMed  CAS  Google Scholar 

  13. Johnson JR. Kuskowski MA, Wilt TJ: Systematic review: antimicrobial urinary catheters to prevent catheter associated urinary tract infection in hospitalized patients. Ann Intern Med 2006, 144:116–126.

    PubMed  Google Scholar 

  14. Stensballe J, Tvede M, Looms D, et al.: Infection risk with nitrofurazone-impregnated urinary catheters in trauma patients. Ann Intern Med 2007, 147:285–293.

    PubMed  Google Scholar 

  15. Trautner BW, Hull RA, Thornby JI, Darouiche RO: Coating urinary catheters with an avirulent strain of Escherichia coli as a means to establish asymptomatic colonization. Infect Control Hosp Epidemiol 2007, 28:92–94.

    Article  PubMed  Google Scholar 

  16. Niel-Weise BS, Van der Broek PJ: Urinary catheter policies for long-term bladder drainage. Cochrane Database Syst Rev 2005, 25(1):CD004201.

    Google Scholar 

  17. Salomon J, Denys P, Merle C, et al.: Prevention of urinary tract infection in spinal cord-injured patients: safety and efficacy of a weekly oral cyclic antibiotic (WOCA) program with a 2 year follow-up-an observational prospective study. J Antimicrob Chemother 2006: 57:784–788.

    Article  PubMed  CAS  Google Scholar 

  18. Stickler DJ, Jones SM, Adusei GO, et al.: A clinical assessment of the performance of a sensor to detect crystalline biofilm formation on indwelling bladder catheters. BJU Int 2006, 98:1244–1249.

    Article  PubMed  Google Scholar 

  19. Hazan Z, Zumeris J, Jacob H, et al.: Effective prevention of microbial biofilm formation on medical devices by low-energy surface acoustic waves. Antimicrob Agents Chemother 2006, 50:4144–4152.

    Article  PubMed  CAS  Google Scholar 

  20. Burton E, Gawande PV, Yakandawala K, et al.: Antibiofilm activity of GlmU enzyme inhibitors against catheter-associated uropathogens. Antimicrob Agents Chemother 2006, 50:1835–1840.

    Article  PubMed  CAS  Google Scholar 

  21. Peterson J, Kaul S, Khashab M, et al.: A double-blind, randomized comparison of levofloxacin 750 mg once-daily for five days with ciprofloxacin 400/500 mg twice-daily for 10 days for the treatment of complicated urinary tract infections and acute pyelonephritis. Urology 2008, 71:17–22.

    Article  PubMed  Google Scholar 

  22. Dow G, Rao P, Harding G, et al.: A prospective, randomized trial of 3 or 14 days of ciprofloxacin treatment for acute urinary tract infection in patients with spinal cord injury. Clin Infect Dis 2004, 39:658–664.

    Article  PubMed  CAS  Google Scholar 

  23. Pohl A: Modes of administration of antibiotics for symptomatic severe urinary tract infections. Cochrane Database Syst Rev 2007, 4:CD003237.

    PubMed  Google Scholar 

  24. Wald H, Kramer A: Nonpayment for harms resulting from medical care. Catheter-associated urinary tract infections. JAMA 2007, 298:2782–2784.

    Article  PubMed  CAS  Google Scholar 

  25. Saint S, Kowalski C, Kaufman S, et al.: Preventing hospital-acquired urinary tract infections in the United States: a national study. Clin Infect Dis 2008, 46:243–250.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Thomas M. Hooton.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lichtenberger, P., Hooton, T.M. Complicated urinary tract infections. Curr Infect Dis Rep 10, 499–504 (2008). https://doi.org/10.1007/s11908-008-0081-0

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11908-008-0081-0

Keywords

Navigation