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DCCT and EDIC Studies in Type 1 Diabetes: Lessons for Diabetic Neuropathy Regarding Metabolic Memory and Natural History

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Abstract

The DCCT/EDIC (Diabetes Control and Complications Trial/ Epidemiology of Diabetes Interventions and Complications) provides a comprehensive characterization of the natural history of diabetic neuropathy in patients with type 1 diabetes and provides insight into the impact of intensive insulin therapy in disease progression. The lessons learned about the natural history of distal symmetrical polyneuropathy and cardiovascular autonomic neuropathy and the impact of glycemic control on neuropathy are discussed in this review.

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References

Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Acknowledgments

Participating neurologists and electromyographers are listed in the Disclosure section. A complete list of participants in the DCCT/EDIC research group can be found in Archives of Ophthalmology 2008, 126:1713.

Disclosure

The DCCT/EDIC project is supported by contracts with the Division of Diabetes, Endocrinology and Metabolic Diseases of the National Institute of Diabetes and Digestive and Kidney Diseases, National Eye Institute, National Institute of Neurological Disorders and Stroke, the General Clinical Research Centers Program and the Clinical and Translational Science Awards Program, National Center for Research Resources, and by Genentech through a Cooperative Research and Development Agreement with the National Institute of Diabetes and Digestive and Kidney Diseases.

Contributors of free or discounted supplies and/or equipment include the following: Lifescan, Roche, Aventis, Eli Lilly, OmniPod, Can-Am, Beckton-Dickinson, Animas, Medtronic, Medtronic Minimed, Bayer (donation one time in 2008), and Omron.

Dr. Rodica Pop-Busui is also supported by the American Diabetes Association Grant 1-08-CR-48, the Juvenile Diabetes Research Foundation Grant 1-2008-1025, and the Juvenile Diabetes Research Foundation for the Study of Complications of Diabetes Grant 4-200-421. No other potential conflicts of interest relevant to this article were reported.

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Authors and Affiliations

  1. Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI, USA

    Rodica Pop-Busui, William H. Herman & Catherine L. Martin

  2. Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA

    Eva L. Feldman & James W. Albers

  3. Department of Neurology, Mayo Clinic, Rochester, MN, USA

    Phillip A. Low

  4. The DCCT/EDIC Research Group, Box DCCT/EDIC, The Biostatistics Center, George Washington University, Rockville, MD, USA

    Patricia A. Cleary, Barbara H. Waberski & John M. Lachin

Authors
  1. Rodica Pop-Busui
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  2. William H. Herman
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  3. Eva L. Feldman
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  4. Phillip A. Low
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  5. Catherine L. Martin
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  6. Patricia A. Cleary
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  7. Barbara H. Waberski
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  8. John M. Lachin
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  9. James W. Albers
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Correspondence to Rodica Pop-Busui.

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Pop-Busui, R., Herman, W.H., Feldman, E.L. et al. DCCT and EDIC Studies in Type 1 Diabetes: Lessons for Diabetic Neuropathy Regarding Metabolic Memory and Natural History. Curr Diab Rep 10, 276–282 (2010). https://doi.org/10.1007/s11892-010-0120-8

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  • DOI: https://doi.org/10.1007/s11892-010-0120-8

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