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Noninfectious Immune-Mediated Uveitis and Ocular Inflammation

  • AUTOIMMUNITY (TK TARRANT, SECTION EDITOR)
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Abstract

Noninfectious uveitis encompasses a diverse group of ocular inflammatory disorders that share an underlying immune etiology and may be associated with systemic disease or confined primarily to the eye. Uveitis is commonly classified by anatomical location of inflammation into anterior, intermediate, posterior, and panuveitis. The treatment of noninfectious uveitis consists of corticosteroids, immunosuppressive agents, and surgically placed steroid implants. We review the epidemiology, immunopathology, and clinical features of several noninfectious immune-mediated uveitides, including HLA-B27 acute anterior uveitis, juvenile idiopathic arthritis, intermediate uveitis, sarcoidosis, Behcet’s disease, Vogt-Koyanagi-Harada syndrome, sympathetic ophthalmia, and white dot syndromes. We also discuss the stepwise approach to medical treatment of immune-mediated uveitis as well as the characteristics, safety, and efficacy of immunosuppressive agents used to treat ocular inflammatory disease.

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Conflict of Interest

Rex McCallum has received royalties from UpToDate.

Jennifer Pan and Manuj Kapur declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Texas Tech University Health Sciences Center – Paul L. Foster School of Medicine, El Paso, TX, 79905, USA

    Jennifer Pan

  2. University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX, 77555-1106, USA

    Manuj Kapur

  3. University of Texas Medical Branch at Galveston, 301 University Blvd., Galveston, TX, 77555-0133, USA

    Rex McCallum

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  1. Jennifer Pan
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  2. Manuj Kapur
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  3. Rex McCallum
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Correspondence to Rex McCallum.

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This article is part of the Topical Collection on Autoimmunity

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Pan, J., Kapur, M. & McCallum, R. Noninfectious Immune-Mediated Uveitis and Ocular Inflammation. Curr Allergy Asthma Rep 14, 409 (2014). https://doi.org/10.1007/s11882-013-0409-1

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