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Physical activity among adult survivors of childhood lower-extremity sarcoma

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Abstract

Introduction

Adult survivors of childhood lower-extremity sarcoma are largely physically inactive, a behavior which potentially compounds their health burden. Altering this behavior requires understanding those factors that contribute to their physical inactivity. Therefore, this investigation sought to identify factors associated with inactivity in this subpopulation of cancer survivors.

Methods

Demographic, personal, treatment, and physical activity information from adult survivors of childhood lower-extremity sarcomas was obtained from the Childhood Cancer Survivor Study (CCSS) cohort. Generalized linear models were used to identify variables that best identified those individuals who were physically inactive.

Results

Only 41% of survivors met Center for Disease Control (CDC) activity guidelines. Survivors were 1.20 (95% confidence intervals (CI) 1.11–1.30) more likely compared to CCSS sibling cohort and 1.12 (95% CI 1.10–1.15) times more likely than the general population to fail to meet CDC guidelines. Significant predictors of physical inactivity included female sex, hemipelvectomy surgery, and platinum and vinca alkaloid chemotherapy.

Conclusions

The primary findings of this study are that survivors of childhood onset lower-extremity sarcoma are (1) highly likely to be physically inactive and (2) less likely than their siblings or the general population to regularly exercise. This study has identified treatment-related risk factors associated with inactivity that will help health and wellness practitioners develop successful exercise interventions to help these survivors achieve recommended levels of physical activity for health.

Implications for cancer survivors

These results suggest that physical activity interventions for adult survivors of childhood lower-extremity sarcomas should be sex specific and responsive to unique physical late effects experienced by these survivors.

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Acknowledgments

Funding for this study was provided by the National Cancer Institute Grant No. CA 55727 (L.L. Robison, P.I.), with additional support provided to St Jude Children's Research Hospital by the National Cancer Institute Cancer Center Support (CORE) grant CA 21765 and by the American Lebanese Syrian Associated Charities (ALSAC). We would also like to acknowledge the American Physical Therapy Association (APTA) Oncology Section for their assistance and support in the development of the manuscript.

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Authors and Affiliations

  1. Harrison Medical Center, Outpatient Rehabilitation, 2625 Wheaton Way, Suite A, Bremerton, WA, 98310, USA

    Meredith A. Wampler

  2. Adjunct Research Scholar, University of Pennsylvania, Philadelphia, PA, USA

    Mary Lou Galantino

  3. St. Jude Children’s Research Hospital, Memphis, TN, USA

    Sujuan Huang, Melissa M. Hudson, Gregory T. Armstrong, Leslie L. Robison & Kirsten K. Ness

  4. St. Catherine University, Minneapolis, MN, USA

    Laura S. Gilchrist

  5. Penn State Hershey College of Medicine at The Pennsylvania State University, Hershey, PA, USA

    Victoria G. Marchese

  6. University of Texas M. D. Anderson Cancer Center, Houston, TX, USA

    G. Stephen Morris & Marilyn Stovall

  7. American Physical Therapy Association, Alexandria, VA, USA

    David A. Scalzitti

  8. Memorial Sloan Kettering Cancer Center, New York, NY, USA

    Kevin C. Oeffinger

  9. Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Wendy M. Leisenring

  10. Stockton University, Stockton, NJ, USA

    Mary Lou Galantino

  11. Children’s Hospitals and Clinics of Minnesota, Minneapolis, MN, USA

    Laura S. Gilchrist

  12. Lebanon Valley College, Annville, PA, USA

    Victoria G. Marchese

Authors
  1. Meredith A. Wampler
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  2. Mary Lou Galantino
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  3. Sujuan Huang
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  8. Melissa M. Hudson
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  11. Wendy M. Leisenring
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  12. Gregory T. Armstrong
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  13. Leslie L. Robison
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  14. Kirsten K. Ness
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Corresponding author

Correspondence to Meredith A. Wampler.

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Wampler, M.A., Galantino, M.L., Huang, S. et al. Physical activity among adult survivors of childhood lower-extremity sarcoma. J Cancer Surviv 6, 45–53 (2012). https://doi.org/10.1007/s11764-011-0187-5

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  • DOI: https://doi.org/10.1007/s11764-011-0187-5

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