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Glucose Profiles in Pregnant Women After a Gastric Bypass

Findings from Continuous Glucose Monitoring

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Abstract

Background

The diagnosis of gestational diabetes mellitus (GDM) usually requires an oral glucose tolerance test, but this procedure seems inappropriate after gastric bypass surgery (Roux-en-Y gastric bypass (RYGB)) due to specific altered glycemic responses. We aimed here at describing continuous glucose monitoring (CGM) profile of pregnant women after RYGB.

Methods

CGM was performed in 35 consecutive pregnant women after RYGB at 26.2 ± 5 weeks of gestation.

Results

After RYGB, pregnant women display high postprandial interstitial glucose (IG) peaks and low IG before and 2 h after meals. The postprandial IG peak is reached early, within 54 ± 9 min. The maximum IG values reach 205 mg/dl, and the percentage of time above 140 mg/dl (6.6 ± 7 %) is similar to what is described in GDM women.

Conclusions

This study is the first to describe CGM profile in pregnant women after RYGB. CGM features are similar to those of non-pregnant post-RYGB patients, characterized by wide and rapid changes in postprandial IG, and high exposure to hyperglycemia. The exposure to hyperglycemia is similar to what is reported in GDM although the time to postprandial peak is shorter. CGM could be an additional useful approach to screen for glucose intolerance during pregnancy after RYGB.

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Acknowledgments

C. B., P. R., and H. H. researched data and wrote the manuscript. F. L. recruited patients, contributed to the data collection, and reviewed the manuscript. O. P. and P. G. contributed to the discussion and reviewed the manuscript. M. B. recruited patients and reviewed the manuscript. C.V. participated in the data collection and reviewed the manuscript. L. C. contributed to the statistical analysis. P. Ritz is the guarantor and takes responsibility for the contents of the article.

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Authors and Affiliations

  1. Department of Diabetology, Metabolic Diseases, and Nutrition, CHU Toulouse, Toulouse, France

    Camille Bonis, Françoise Lorenzini, Pierre Gourdy, Charlotte Vaurs, Laurent Cazals & Hélène Hanaire

  2. Department of Obstetrics and Gynecology, Paule de Viguier Hospital, CHU of Toulouse, Toulouse, France

    Françoise Lorenzini & Olivier Parant

  3. Nutrition Unit, Cardiovascular and Metabolism Division, Larrey Hospital, CHU of Toulouse, Toulouse, France

    Monelle Bertrand & Patrick Ritz

  4. University of Toulouse 3, Toulouse, France

    Hélène Hanaire

Authors
  1. Camille Bonis
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  2. Françoise Lorenzini
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  3. Monelle Bertrand
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  4. Olivier Parant
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  9. Hélène Hanaire
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Corresponding author

Correspondence to Hélène Hanaire.

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The authors declare that they have no competing interests.

Statement of Informed Consent

Informed consent was obtained from all individual participants included in the study.

Statement of Human Rights

The study has been approved by the local research ethical committee.

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Bonis, C., Lorenzini, F., Bertrand, M. et al. Glucose Profiles in Pregnant Women After a Gastric Bypass. OBES SURG 26, 2150–2155 (2016). https://doi.org/10.1007/s11695-016-2061-z

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  • DOI: https://doi.org/10.1007/s11695-016-2061-z

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