Abstract
Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58–0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.
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Afshar, S., Kelly, S.B., Seymour, K. et al. The Effects of Bariatric Surgery on Colorectal Cancer Risk: Systematic Review and Meta-analysis. OBES SURG 24, 1793–1799 (2014). https://doi.org/10.1007/s11695-014-1359-y
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DOI: https://doi.org/10.1007/s11695-014-1359-y