Abstract
Obesity is considered a worldwide health problem of epidemic proportions. Bariatric surgery remains the most effective treatment for patients with severe obesity, resulting in improved obesity-related co-morbidities and increased overall life expectancy. However, weight recidivism has been observed in a subset of patients post-bariatric surgery. Weight recidivism has significant medical, societal and economic ramifications. Unfortunately, there is a very limited understanding of how to predict which bariatric surgical patients are more likely to regain weight following surgery and how to appropriately treat patients who have regained weight. The objective of this paper is to systematically review the existing literature to assess the incidence and causative factors associated with weight regain following bariatric surgery. An electronic literature search was performed of the Medline, Embase and Cochrane library databases along with the PubMed US national library from January 1950 to December 2012 to identify relevant articles. Following an initial screen of 2,204 titles, 1,437 abstracts were reviewed and 1,421 met exclusion criteria. Sixteen studies were included in this analysis: seven case series, five surveys and four non-randomized controlled trials, with a total of 4,864 patients for analysis. Weight regain in these patients appeared to be multi-factorial and overlapping. Aetiologies were categorized as patient specific (psychiatric, physical inactivity, endocrinopathies/metabolic and dietary non-compliance) and operation specific. Weight regain following bariatric surgery varies according to duration of follow-up and the bariatric surgical procedure performed. The underlying causes leading to weight regain are multi-factorial and related to patient- and procedure-specific factors. Addressing post-surgical weight regain requires a systematic approach to patient assessment focusing on contributory dietary, psychologic, medical and surgical factors.
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Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377(9765):557–67. Prospective Studies Collaboration.
Whitlock G, Lewington S, Sherliker P, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083–96.
Buchwald H, Avidor Y, Braunwald E, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA. 2004;292:1724–1734 (Erratum in JAMA. 2005; 293:1728).
Adams TD, Gress RE, Smith SC, et al. Long-term mortality after gastric bypass surgery. N Engl J Med. 2007;357:753–61.
Pope GD, Finlayson SR, Kemp JA, et al. Life expectancy benefits of gastric bypass surgery. Surg Innov. 2006;13:265–73.
Sjostrom L, Lindroos AK, Peltonen M, et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med. 2004;351:2683–93.
Sjostrom CD, Lissner L, Wedel H, et al. Reduction in incidence of diabetes, hypertension and lipid disturbances after intentional weight loss induced by bariatric surgery: the SOS Intervention Study. Obes Res. 1999;7:477–84.
Sugerman HJ. Bariatric surgery for severe obesity. J Assoc Acad Minor Phys. 2001;12:129–36.
Gracia JA, Martínez M, Elia M, et al. Obesity results surgery depends on technique performed: long term outcome. Obes Surg. 2009;19:432–8.
Catalano MF, Rudic G, Anderson AJ, et al. Weight gain after bariatric surgery as a result of a large gastric stoma: endotherapy with sodium morrhuate may prevent the need for surgical revision. Gastrointest Endosc. 2007;66:240–5.
Engström BE, Ohrvall M, Sundbom M, et al. Meal suppression of circulating ghrelin is normalized in obese individuals following gastric bypass surgery. Int J Obes (Lond). 2007;31:476–80.
Christou NV, Look D, MacLean LD. Weight gain after short and long-limb gastric bypass in patients followed for longer than 10 years. Ann Surg. 2006;244:734–40.
Margo DO, Geloneze B, Delfini R, et al. Long-term weight regain after gastric bypass: a 5-year prospective study. Obes Surg. 2008;18:648–51.
Bohdjalian A, Langer FB, Shakeri-Leidenmühler S, et al. Sleeve gastrectomy as sole and definitive bariatric procedure: 5-year results for weight loss and ghrelin. Obes Surg. 2010;20(5):535–40. doi:10.1007/s11695-009-0066-6.
Yimcharoen P, Heneghan HM, Singh M, et al. Endoscopic findings and outcomes of revisional procedures for patients with weight recidivism after gastric bypass. Surg Endosc. 2011;25(10):3345–52. doi:10.1007/s00464-011-1723-0.
Heneghan HM, Yimcharoen P, Brethauer SA, et al. Influence of pouch and stoma size on weight loss after gastric bypass. Surg Obes Relat Dis. 2012;8(4):408–15. doi:10.1016/j.soard.2011.09.010.
Kalarchian MA, Marcus MD, Wilson GT, et al. Binge eating among gastric bypass patients at long-term follow-up. Obes Surg. 2002;12:270–5.
Odom J, Zalesin KC, Washington TL, et al. Behavioral predictors of weight regain after bariatric surgery. Obes Surg. 2010;20:349–56.
Colles SL, Dixon JB, O'Brien PE. Grazing and loss of control related to eating: two high-risk factors following bariatric surgery. Obesity. 2008;16:615–22.
Freire RH, Borges MC, Alvarez-Leite JI, et al. Food quality, physical activity, and nutritional follow-up as determinant of weight regain after Roux-en-Y gastric bypass. Nutrition. 2012;28(1):53–8. doi:10.1016/j.nut.2011.01.011.
Kofman MD, Lent MR, Swencionis C. Maladaptive eating patterns, quality of life, and weight outcomes following gastric bypass: results of an Internet survey. Obesity (Silver Spring). 2010;18(10):1938–43. doi:10.1038/oby.2010.27.
Bond DS, Phelan S, Leahey TM, et al. Weight-loss maintenance in successful weight losers: surgical vs non-surgical methods. Int J of Obes (Lond). 2009;33:173–80.
Roslin M, Damani T, Oren J, et al. Abnormal glucose tolerance testing following gastric bypass demonstrates reactive hypoglycemia. Surg Endosc. 2011;25(6):1926–32. doi:10.1007/s00464-010-1489-9.
Rutledge T, Groesz LM, Savu M. Psychiatric factors and weight loss patterns following gastric bypass surgery in a veteran population. Obes Surg. 2011;21(1):29–35. doi:10.1007/s11695-009-9923-6.
Anti-ghrelin vaccine decreases food intake and increases calorie burning in mice. N.p., n.d. Web. 02 Feb 2013.
Sarwer DB, Wadden TA, Moore RH, et al. Preoperative eating behavior, postoperative dietary adherence and weight loss following gastric bypass surgery. Surg Obes Relat Dis. 2008;4:640–6.
Faria SL, de Oliveira KE, Lins RD, et al. Nutritional management of weight regain after bariatric surgery. Obes Surg. 2010;20:135–9.
Hsu LK, Benotti PN, Dwyer J, et al. Nonsurgical factors that influence the outcome of bariatric surgery: a review. Psychosom Med. 1998;60:338–46.
Saunders R. “Grazing”: a high-risk behavior. Obes Surg. 2004;14:98–102.
Kinzl JF. Psychosocial predictors of weight loss after bariatric surgery. Obes Surg. 2006;16(9):1198–204.
van Hout GC, van Oudhersden I, van Heck GL. Psychological profile of the morbidly obese. Obes Surg. 2004;14:579–88.
Levy LD, Fleming JP, Klar D. Treatment of refractory obesity in severely obese adults following management of newly diagnosed attention deficit hyperactivity disorder. Int J Obes (Lond). 2009;33:326–34.
Goldfein JA, Walsh BT, Devlin MJ, et al. Eating behavior in binge eating disorder. Int J Eat Disord. 1993;14:427–31.
Agras WS, Telch CF, Arnow B, et al. Weight loss, cognitive-behavioral, and desipramine treatments in binge eating disorder. An additive design. Behav Ther. 1994;25:225–38.
Leahey TM, Bond DS, Irwin SR, et al. When is the best time to deliver behavioral intervention to bariatric surgery patients: before or after surgery? Surg Obes Relat Dis. 2009;5:99–102.
Evanas RK, Bond DS, Wolfe LG, et al. Participation in 150 min/wk of moderate or higher intensity physical activity yields greater weight loss after gastric bypass surgery. Surg Obes Relat Dis. 2007;3:526–30.
King WC, Belle SH, Eid GM, et al. Physical activity levels of patients undergoing bariatric surgery in the longitudinal assessment of bariatric surgery study. Surg Obes Relat Dis. 2008;4:721–8.
Miller GD, Nicklas BJ, You T, et al. Physical function improvements after laparoscopic Roux-en-Y gastric bypass surgery. Surg Obes Relat Dis. 2009;5:530–7.
Goldsmith R, Joanisse DR, Gallagher D, et al. Effects of experimental weight perturbation on skeletal muscle work efficiency, fuel utilization, and biochemistry in human subjects. Am J Physiol Regul Integr Comp Physiol. 2010;298:R79–88.
Kuzmak LI, Burak E. Pouch enlargement: myth or reality? Impressions from serial upper gastrointestinal series in silicone gastric banding patients. Obes Surg. 1993;3:57–62.
DeMaria EJ, Sugerman HJ, Meador JG, et al. High failure rate after laparoscopic adjustable silicone gastric banding for treatment of morbid obesity. Ann Surg. 2001;233:809–18.
Eid I, Birch DW, Sharma AM, et al. Complications associated with adjustable gastric banding for morbid obesity: a surgeon's guides. Can J Surg. 2011;54(1):61–6.
Lanthaler M, Strasser S, Aigner F, et al. Weight loss and quality of life after gastric band removal or deflation. Obes Surg. 2009;19:1401–8.
Stroh S. Fourteen year long term follow-up after AGB. Journal of Obesity. Volume 2011, Article ID 128451, 6 pages. doi:10.1155/2011/128451.
Thompson CC, Slattery J, Bundga ME, et al. Peroral endoscopic reduction of dilated gastrojejunal anastomosis after Roux en Y gastric bypass: a possible new option for patients with weight regain. Surg Endosc. 2006;20:1744–8.
Cucchi SG, Pories WJ, MacDonald KG. Gastrogastric fistulas. A complication of divided gastric bypass surgery. Ann Surg. 1995;221(4):387–91.
Filho AJ, William K, Nassif LS, et al. Gastrogastric fistula: a possible complication of Roux-en-Y gastric bypass. JSLS. 2006;10:326–31.
Capella JF, Capella RF. Gastro-gastric fistulas and marginal ulcers in gastric bypass procedures for weight reduction. Obes Surg. 1999;9:22–7.
Weiner RA, Weiner S, Pomhoff I, et al. Laparoscopic sleeve gastrectomy—influence of sleeve size and resected gastric volume. Obes Surg. 2007;17:1297–305.
Braghetto I, Cortes C, Herquiñigo D, et al. Evaluation of the radiological gastric capacity and evolution of the BMI 2–3 years after sleeve gastrectomy. Obes Surg. 2009;19:1262–9.
Langer FB, Bohdjalian A, Shakeri-Manesch S, et al. Inadequate weight loss vs secondary weight regain: laparoscopic conversion from gastric banding to Roux-en-Y gastric bypass. Obes Surg. 2008;18:1381–6.
Müller MK, Attigah N, Wildi S, et al. High secondary failure rate of rebanding after failed gastric banding. Surg Endosc. 2008;22:448–53.
Langer FB, Bohdjalian A, Shakeri-Leidenmühler S, et al. Conversion from sleeve gastrectomy to Roux-en-Y gastric bypass—indications and outcome. Obes Surg. 2010;20:835–40.
Conflicts of interest
Shahzeer Karmali, Balpreet Brar, Christopher de Gara, Arya M Sharma and Daniel Birch have no conflicts of interest to report in respect to the drafting, review and final editing of this manuscript. Shahzeer Karmali and Daniel Birch serve as consultants for Ethicon Endosurgery, Covidien and BARD. These associations did not interfere with this manuscript.
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Karmali, S., Brar, B., Shi, X. et al. Weight Recidivism Post-Bariatric Surgery: A Systematic Review. OBES SURG 23, 1922–1933 (2013). https://doi.org/10.1007/s11695-013-1070-4
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DOI: https://doi.org/10.1007/s11695-013-1070-4