Zusammenfassung
Adipositas ist eine multifaktoriell bedingte Erkrankung, bei deren Pathogenese genetische Faktoren, Überernährung, Bewegungsmangel sowie vielfältige andere Mechanismen eine Rolle spielen. Etliche Studien des vergangenen Jahrs leisteten nicht nur einen Beitrag zum besseren Verständnis der Entstehung von Adipositas und zur Assoziation mit Begleiterkrankungen, sondern auch zu therapeutischen Strategien. Entsprechend den aktuellen Leitlinien sind Ernährungs-, Bewegungs- und Verhaltenstherapie Grundlage der Behandlung von Adipositas; hierbei sind die bevorzugt zum Einsatz kommenden Strategien immer wieder Gegenstand der Diskussion. Während der Stellenwert einer Pharmakotherapie von Adipositas zuletzt eher rückläufig erschien, gilt für die Adipositaschirurgie das Gegenteil. Auch die publizierte Datenlage zur chirurgischen Therapie war in der jüngeren Vergangenheit eher günstig.
Abstract
Obesity is a multifactorial disease with a pathogenesis including genetic factors, overeating, physical inactivity and a variety of other factors. Numerous recently published studies have contributed to a better understanding of relevant pathogenic mechanisms and the association with accompanying diseases as well as therapeutic strategies. According to current guidelines, dietary, physical and behavioral therapy are the basis for the treatment of obesity. There is, however, an ongoing debate about the different strategies which are actually used in the clinical setting. While the relevance of pharmacotherapy for obesity has recently appeared to decline, the opposite can be observed for bariatric surgery. Recently published studies with favorable data support the use of surgical strategies in obese subjects when indicated, as also suggested in current international guidelines.
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Hamann, A. Aktuelles zur Adipositastherapie. Diabetologe 8, 386–396 (2012). https://doi.org/10.1007/s11428-011-0857-y
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DOI: https://doi.org/10.1007/s11428-011-0857-y