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Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity

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Abstract

Tart cherries are particularly high in anthocyanins and are believed to have many health benefits, including reducing inflammation and oxidative stress. However, comparison between dosages and formulations are lacking. Forty-eight participants were randomly allocated to one of six experimental treatment groups where they ingested tart cherry or placebo in either juice (240 ml per bottle) or powdered capsule form (480 mg per capsule) once or twice daily for 48 h and markers of inflammation (uric acid (UA), high-sensitivity C-reactive protein (hsCRP)) and oxidative capacity (plasma oxygen radical absorbance capacity (ORAC)) were measured. There was a group x time interaction for UA (p = 0.02), which declined up to 24 h post ingestion for a single capsule dose, up to 8 h for a two capsule dose, and up to 2 h for a single juice dose. There was an increase in UA from 8 h until 48 h post ingestion in a single juice dose. Overall, there was an average 8% decrease in UA. There was no significant change over time in hsCRP (p = 0.64) or ORAC (p = 0.42) or between groups in hsCRP (p = 0.47) or ORAC (p = 0.21). Our data indicates tart cherry ingestion can transiently decrease UA and not maintained with continued supplementation. Additionally, there were differences in formulations and doses indicating a single powdered capsule is most effective for lowering UA suggesting capsules may be used by those who do not enjoy the taste of tart cherry juice. This study was registered at ClinicalTrials.gov, NCT04497077, 7/29/2020, retrospectively registered.

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Data Availability

Data is available upon request.

References

  1. Li D, Wang P, Luo Y, Zhao M, Chen F (2017) Health benefits of anthocyanins and molecular mechanisms: update from recent decade. Crit Rev Food Sci Nutr 57:1729–1741. https://doi.org/10.1080/10408398.2015.1030064

    Article  CAS  PubMed  Google Scholar 

  2. Zafra-Stone S, Yasmin T, Bagchi M, Chatterjee A, Vinson JA, Bagchi D (2007) Berry anthocyanins as novel antioxidants in human health and disease prevention. Mol Nutr Food Res 51:675–683. https://doi.org/10.1002/mnfr.200700002

    Article  CAS  PubMed  Google Scholar 

  3. Halvorsen BL, Carlsen MH, Phillips KM, Bøhn SK, Holte K, Jacobs DR Jr, Blomhoff R (2006) Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States. Am J Clin Nutr 84:95–135. https://doi.org/10.1093/ajcn/84.1.95

  4. Wang H, Nair MG, Strasburg GM, Booren AM, Gray JI (1999) Antioxidant polyphenols from tart cherries (Prunus cerasus). J Agric Food Chem 47:840–844. https://doi.org/10.1021/jf980936f

  5. Bell PG, Stevenson E, Davison GW, Howatson G (2016) The effects of Montmorency tart cherry concentrate supplementation on recovery following prolonged, intermittent exercise. Nutrients 8:441. https://doi.org/10.3390/nu8070441

    Article  CAS  PubMed Central  Google Scholar 

  6. Bell PG, Walshe IH, Davison GW, Stevenson E, Howatson G (2014) Montmorency cherries reduce the oxidative stress and inflammatory responses to repeated days high-intensity stochastic cycling. Nutrients 6:829–843. https://doi.org/10.3390/nu6020829

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bell PG, Walshe IH, Davison GW, Stevenson EJ, Howatson G (2015) Recovery facilitation with Montmorency cherries following high-intensity, metabolically challenging exercise. Appl Physiol Nutr Metab 40:414–423. https://doi.org/10.1139/apnm-2014-0244

    Article  PubMed  Google Scholar 

  8. Howatson G, McHugh MP, Hill JA et al (2010) Influence of tart cherry juice on indices of recovery following marathon running. Scand J Med Sci Sports 20:843–852. https://doi.org/10.1111/j.1600-0838.2009.01005.x

    Article  CAS  PubMed  Google Scholar 

  9. Schumacher HR, Pullman-Mooar S, Gupta SR, Dinnella JE, Kim R, McHugh MP (2013) Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee. Osteoarthr Cartil 21:1035–1041. https://doi.org/10.1016/j.joca.2013.05.009

    Article  CAS  Google Scholar 

  10. Zhang Y, Neogi T, Chen C, Chaisson C, Hunter DJ, Choi HK (2012) Cherry consumption and decreased risk of recurrent gout attacks. Arthritis Rheum 64:4004–4011. https://doi.org/10.1002/art.34677

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Bell P, Gaze D, Davison G et al (2014) Montmorency tart cherry (Prunus cerasus L.) concentrate lowers uric acid, independent of plasma cyanidin-3-O-glucosiderutinoside. J Funct Foods 11:82–90. https://doi.org/10.1016/j.jff.2014.09.004

  12. Charron CS, Kurilich AC, Clevidence BA, Simon PW, Harrison DJ, Britz SJ, Baer DJ, Novotny JA (2009) Bioavailability of anthocyanins from purple carrot juice: effects of acylation and plant matrix. J Agric Food Chem 57:1226–1230. https://doi.org/10.1021/jf802988s

    Article  CAS  PubMed  Google Scholar 

  13. Manach C, Williamson G, Morand C, Scalbert A, Rémésy C (2005) Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr 81:230S–242S. https://doi.org/10.1093/ajcn/81.1.230S

    Article  CAS  PubMed  Google Scholar 

  14. Keane KM, Bell PG, Lodge JK, Constantinou CL, Jenkinson SE, Bass R, Howatson G (2016) Phytochemical uptake following human consumption of Montmorency tart cherry (Prunus cerasus L.) and influence of phenolic acids on vascular smooth muscle cells in vitro. Eur J Nutr 55:1695–1705. https://doi.org/10.1007/s00394-015-0988-9

  15. Desai T, Roberts M, Bottoms L (2019) Effects of Montmorency tart cherry supplementation on cardio-metabolic markers in metabolic syndrome participants: a pilot study. J Funct Foods 57:286–298. https://doi.org/10.1016/j.jff.2019.04.005

    Article  CAS  Google Scholar 

  16. Levers K, Dalton R, Galvan E, O’Connor A, Goodenough C, Simbo S, Mertens-Talcott SU, Rasmussen C, Greenwood M, Riechman S, Crouse S, Kreider RB (2016) Effects of powdered Montmorency tart cherry supplementation on acute endurance exercise performance in aerobically trained individuals. J Int Soc Sports Nutr 13:22. https://doi.org/10.1186/s12970-016-0133-z

    Article  PubMed  PubMed Central  Google Scholar 

  17. Martin KR, Coles KM (2019) Consumption of 100% tart cherry juice reduces serum Urate in overweight and obese adults. Curr Dev Nutr 3:nzz011. https://doi.org/10.1093/cdn/nzz011

  18. Zhu Y, Pandya BJ, Choi HK (2011) Prevalence of gout and hyperuricemia in the US general population: the National Health and nutrition examination survey 2007-2008. Arthritis Rheum 63:3136–3141. https://doi.org/10.1002/art.30520

    Article  PubMed  Google Scholar 

  19. Choi HK, Ford ES, Li C, Curhan G (2007) Prevalence of the metabolic syndrome in patients with gout: the third National Health and nutrition examination survey. Arthritis Care Res 57:109–115. https://doi.org/10.1002/art.22466

    Article  Google Scholar 

  20. Fernández-García JC, Cardona F, Tinahones FJ (2013) Inflammation, oxidative stress and metabolic syndrome: dietary modulation. Curr Vasc Pharmacol 11:906–919. https://doi.org/10.2174/15701611113116660175

    Article  CAS  PubMed  Google Scholar 

  21. Guo Z, Zhang J, Wang Z, Ang KY, Huang S, Hou Q, Su X, Qiao J, Zheng Y, Wang L, Koh E, Danliang H, Xu J, Lee YK, Zhang H (2016) Intestinal microbiota distinguish gout patients from healthy humans. Sci Rep 6:20602. https://doi.org/10.1038/srep20602

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Chen P-E, Liu C-Y, Chien W-H, Chien CW, Tung TH (2019) Effectiveness of cherries in reducing uric acid and gout: a systematic review. Evid Based Complement Alternat Med 2019:9896757–9896757. https://doi.org/10.1155/2019/9896757

    Article  PubMed  PubMed Central  Google Scholar 

  23. Sproston NR, Ashworth JJ (2018) Role of C-reactive protein at sites of inflammation and infection. Front Immunol 9:754. https://doi.org/10.3389/fimmu.2018.00754

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Abbott W, Brashill C, Brett A, Clifford T (2020) Tart cherry juice: no effect on muscle function loss or muscle soreness in professional soccer players after a match. Int J Sports Physiol Perform 15:249–254. https://doi.org/10.1123/ijspp.2019-0221

    Article  PubMed  Google Scholar 

  25. Beals K, Allison KF, Damell M et al (2017) The effects of a tart cherry beverage on reducing exercise-induced muscle soreness. Isokinet Exerc Sci 25:53–63. https://doi.org/10.3233/IES-160645

    Article  Google Scholar 

  26. Bowtell JL, Sumners DP, Dyer A et al (2011) Montmorency cherry juice reduces muscle damage caused by intensive strength exercise. Med Sci Sports Exerc 43:1544–1551. https://doi.org/10.1249/MSS.0b013e31820e5adc

    Article  CAS  PubMed  Google Scholar 

  27. McCormick R, Peeling P, Binnie M, Dawson B, Sim M (2016) Effect of tart cherry juice on recovery and next day performance in well-trained water polo players. J Int Soc Sports Nutr 13:41. https://doi.org/10.1186/s12970-016-0151-x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Quinlan R, Hill JA (2020) The efficacy of tart cherry juice in aiding recovery after intermittent exercise. Int J Sports Physiol Perform 15:368–374. https://doi.org/10.1123/ijspp.2019-0101

    Article  Google Scholar 

  29. Morehen JC, Clarke J, Batsford J, Barrow S, Brown AD, Stewart CE, Morton JP, Close GL (2020) Montmorency tart cherry juice does not reduce markers of muscle soreness, function and inflammation following professional male rugby league match-play. Eur J Sport Sci:1–10. https://doi.org/10.1080/17461391.2020.1797181

  30. Levers K, Dalton R, Galvan E, Goodenough C, O’Connor A, Simbo S, Barringer N, Mertens-Talcott SU, Rasmussen C, Greenwood M, Riechman S, Crouse S, Kreider RB (2015) Effects of powdered Montmorency tart cherry supplementation on an acute bout of intense lower body strength exercise in resistance trained males. J Int Soc Sports Nutr 12:41. https://doi.org/10.1186/s12970-015-0102-y

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Lynn A, Mathew S, Moore CT, Russell J, Robinson E, Soumpasi V, Barker ME (2014) Effect of a tart cherry juice supplement on arterial stiffness and inflammation in healthy adults: a randomised controlled trial. Plant Foods Hum Nutr 69:122–127. https://doi.org/10.1007/s11130-014-0409-x

    Article  CAS  PubMed  Google Scholar 

  32. Traustadóttir T, Davies SS, Stock AA et al (2009) Tart cherry juice decreases oxidative stress in healthy older men and women. J Nutr 139:1896–1900. https://doi.org/10.3945/jn.109.111716

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Lotito SB, Frei B (2006) Consumption of flavonoid-rich foods and increased plasma antioxidant capacity in humans: cause, consequence, or epiphenomenon? Free Radic Biol Med 41:1727–1746. https://doi.org/10.1016/j.freeradbiomed.2006.04.033

    Article  CAS  PubMed  Google Scholar 

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Acknowledgements

We would like to thank the volunteers for their enthusiastic participation. We would also like to thank Michael Joyce and Michael Boylan for their assistance with data collection.

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Funding

This study was funded by the Marywood University Murray Award for Research and Development.

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Authors and Affiliations

  1. Marywood University Human Physiology Laboratory, Scranton, PA, USA

    Angela R. Hillman & Kathy Uhranowsky

  2. Applied Health Sciences and Wellness, Ohio University, Grover Center E175, Athens, OH, 45701, USA

    Angela R. Hillman

Authors
  1. Angela R. Hillman
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All authors contributed equally to the design, collection and analysis of data, and drafting of the manuscript.

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Correspondence to Angela R. Hillman.

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Ethical approval was provided by the Marywood University Institutional Review Board (protocol 801,765).

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Hillman, A.R., Uhranowsky, K. Acute Ingestion of Montmorency Tart Cherry Reduces Serum Uric Acid but Has no Impact on High Sensitivity C-Reactive Protein or Oxidative Capacity. Plant Foods Hum Nutr 76, 83–89 (2021). https://doi.org/10.1007/s11130-021-00879-7

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