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A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures

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Abstract

The development of an esthesioneuroblastoma outside to the region in which olfactory epithelium exists is extremely rare. Only nine cases were reported in the previous literatures. The author presents a 40 years-old man with ectopic esthesioneuroblastoma in sella turcica. In contrast to the previous nine cases, our case presented unusual presentations—CSF rhinorrhea and meningitis. Endoscopic transphenoid approach with removal of tumor and repair of dura defect followed by radiotherapy offered a good result in this case. Moreover, differential diagnosis and the origin of the ectopic esthsioneuroblastoma would be discussed.

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References

  1. Berger L, Luc R (1924) Esthioneuroepitheliome olfactif. Bull Assoc Fr Etud Cancer 3:410–421

    Google Scholar 

  2. Mc CL, Harris HE (1955) Neurogenic tumors of the nasal fossa. J Am Med Assoc 157(4):318–321

    Google Scholar 

  3. Svane-Kundsen V, Jorgensen KE, Hansen O (1998) Cancer of the nasal cavity and paranasal sinuses: a series of 115 patients. Rhinology 36:2–14

    Google Scholar 

  4. Morris L, Govindaraj S, Genden EM (2004) Primary sphenoid sinus esthesioneuroblastoma. Am J Otolaryngol 25(5):350–353

    Article  PubMed  Google Scholar 

  5. Sarwar M (1979) Primary sellar-parasellar esthesioneuroblastoma. AJR Am J Roentgenol 133(1):140–141

    PubMed  CAS  Google Scholar 

  6. Roy A et al (2000) Correspondence: aesthesioneuroblastoma arising in pituitary gland. Neuropathol Appl Neurobiol 26(2):177–179

    Article  Google Scholar 

  7. Mariani L et al (2004) Esthesioneuroblastoma of the pituitary gland: a clinicopathological entity? Case report and review of the literature. J Neurosurg 101(6):1049–1052

    Google Scholar 

  8. Sajko T et al (2005) Primary sellar esthesioneuroblastoma. Acta Neurochir (Wien) 147(4):447–448; discussion 448

    Article  Google Scholar 

  9. Sharma SC et al (2002) Isolated esthesioneuroblastoma of sphenoid sinus. Am J Otolaryngol 23(5):287–289

    Article  Google Scholar 

  10. Chacko G, Chandi SM, Chandy MJ (1998) Primary sphenoid and petrous apex esthesioneuroblastoma: case report. Br J Neurosurg 12(3):264–266

    Article  PubMed  CAS  Google Scholar 

  11. Chirico G et al (2003) Primary sphenoid esthesioneuroblastoma studied with MR. Clin Imaging 27(1):38–40

    Article  Google Scholar 

  12. Martin TJ et al (2002) Evaluation and surgical management of isolated sphenoid sinus disease. Arch Otolaryngol Head Neck Surg 128(12):1413–1419

    Google Scholar 

  13. Daryl R, Fourney FD (1996) Neoplasms of the paranasal sinuses. In: Winn H, Richard Y, Julian R (eds) Yuomans neurological surgery, 4th edn. pp. 1311–1331

  14. Jakumeit HD (1971) Neuroblastoma of the olfactory nerve. Acta Neurochir (Wien) 25(1):99–108

    Article  CAS  Google Scholar 

  15. Wirsig-Wiechmann CR, Oka Y (2002) The terminal nerve ganglion cells project to the olfactory mucosa in the dwarf gourami. Neurosci Res 44(3):337–341

    Article  PubMed  CAS  Google Scholar 

  16. Wirsig-Wiechmann CR, Wiechmann AF, Eisthen HL (2002) What defines the nervus terminalis? Neurochemical, developmental, and anatomical criteria. Prog Brain Res 141:45–58

    Article  PubMed  CAS  Google Scholar 

  17. Zappia JJ et al (1992) Olfactory neuroblastoma associated with Kallman’s syndrome. J Otolaryngol 21(1):16–9

    Google Scholar 

  18. Kim DW et al (2004) Neoadjuvant etoposide, ifosfamide, and cisplatin for the treatment of olfactory neuroblastoma. Cancer 101(10):2257–2260

    Article  CAS  Google Scholar 

  19. Lund VJ et al (2003) Olfactory neuroblastoma: past, present, and future? Laryngoscope 113(3):502–507

    Article  Google Scholar 

  20. Unger F et al (2005) Combined endoscopic surgery and radiosurgery as treatment modality for olfactory neuroblastoma (esthesioneuroblastoma). Acta Neurochir (Wien) 147(6):595–601; discussion 601–2

    Article  Google Scholar 

  21. Ebersold MJ, Olsen KD, Foote RL, et al (1997) Esthesioneuroblastoma. In: Kaye AH, Laws ER (eds) Brain tumors. Edinburgh, Churchill Livingstone, pp 825–838

  22. Ghaffar S, Salahuddin I (2005) Olfactory neuroblastoma: a case report and review of the literature. Ear Nose Throat J 84(3):150–152

    PubMed  Google Scholar 

  23. Eich HT et al (2003) Multimodality therapy including radiotherapy and chemotherapy improves event-free survival in stage C esthesioneuroblastoma. Strahlenther Onkol 179(4):233–240

    Article  Google Scholar 

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Correspondence to Yung-Hsiao Chiang.

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Lin, JH., Tsai, DH. & Chiang, YH. A primary sellar esthesioneuroblastomas with unusual presentations: a case report and reviews of literatures. Pituitary 12, 70–75 (2009). https://doi.org/10.1007/s11102-007-0081-3

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  • DOI: https://doi.org/10.1007/s11102-007-0081-3

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