Abstract
Purpose
To study the effect of endometrial thickness (ET) and echogenic pattern (EP) in oocyte donation cycles upon pregnancy outcomes.
Methods
Seventy-nine cycles resulting in blastocyst embryo transfer were evaluated. Donors underwent ovarian hyperstimulation using rFSH and GnRH-antagonist. Recipients were synchronized to donors using GnRH-agonist down-regulation followed by fixed dose of estrogen (E2) and progesterone (P4) following hCG. Transvaginal ultrasound (US) obtained ET and EP 10-11 days after initiation of E2 and on day of embryo transfer. Primary outcome was ET and EP in pregnant and non-pregnant cycles. Stimulation and embryology data was analyzed in donors to assess differences prior to transfer.
Results
Fifty-nine cycles resulted in clinical pregnancy. No differences were observed in pregnant vs. non-pregnant cycles in proliferative or secretory ET and EP. Similar baseline and stimulation characteristics were found in pregnant and non-pregnant cycles. Regression analysis showed end thickness were not predictive of pregnancy outcomes.
Conclusions
Endometrial characteristics in recipients prior to and following progesterone were not predictive of pregnancy outcomes.
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The authors do not have any financial grants or other outside funding for this study. None of the authors have any conflict of interests.
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Capsule Endometrial thickness and echogenic pattern do not appear to be predictive of outcomes in oocyte donation cycles.
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Barker, M.A., Boehnlein, L.M., Kovacs, P. et al. Follicular and luteal phase endometrial thickness and echogenic pattern and pregnancy outcome in oocyte donation cycles. J Assist Reprod Genet 26, 243–249 (2009). https://doi.org/10.1007/s10815-009-9312-z
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DOI: https://doi.org/10.1007/s10815-009-9312-z