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1,8-Cineol Attenuates LPS-Induced Acute Pulmonary Inflammation in Mice

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Abstract

Eucalyptol, also known as 1,8-cineol, is a monoterpene and has been shown to exert anti-inflammatory and antioxidant effect. It is traditionally used to treat respiratory disorders due to its secretolytic properties. In the present study, we evaluated the effect of 1,8-cineol on pulmonary inflammation in a mouse model of acute lung injury. We found that 1,8-cineol significantly decreased the level of TNF-α and IL-1β, and increased the level of IL-10 in lung tissues after acute lung injury induced by lipopolysaccharide (LPS). It also reduced the expression of nuclear factor kappa B (NF-κB) p65 and toll-like receptor 4 (TLR4), and myeloperoxidase activity in lung tissues. In addition, 1,8-cineol reduced the amounts of inflammatory cells in bronchoalveolar lavage fluid (BALF), including neutrophils and macrophages, and significantly decreased the protein content in BALF and the lung wet/dry weight (W/D) ratio. Its effect on LPS-induced pulmonary inflammation was associated with suppression of TLR4 and NF-κB expressions. Our results provide evidence that 1,8-cineol inhibits acute pulmonary inflammation, indicating its potential for the treatment of acute lung injury.

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Authors and Affiliations

  1. Department of Pharmacology, Pharmacy and Biological Science College, Weifang Medical University, 7166 Baotong Street, Weifang, 261053, China

    Chunzhen Zhao & Chunyan Fang

  2. Department of Neurosurgery, Shouguang People’s Hospital, 45 Jiankang Street, Shouguang, 262700, China

    Jianbo Sun

  3. Zhejiang Respiratory Drugs Research Laboratory of State Food and Drug Administration of China, College of Medicine, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China

    Fadi Tang

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  1. Chunzhen Zhao
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  2. Jianbo Sun
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Correspondence to Chunzhen Zhao.

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Zhao, C., Sun, J., Fang, C. et al. 1,8-Cineol Attenuates LPS-Induced Acute Pulmonary Inflammation in Mice. Inflammation 37, 566–572 (2014). https://doi.org/10.1007/s10753-013-9770-4

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