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The effects of topical treatment with curcumin on burn wound healing in rats

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Abstract

The present study was designed to determine the role of topical treatment with curcumin (Cur) on burn wound healing in rats. The Wistar-albino rats were randomly allotted into one of three experimental groups: 4th, 8th and 12th day (post burn) and all groups include subgroups which Burn and Burn + Cur. Each group contains 12 animals. Burn wounds were made on the back of rat and Cur was administered topically. At the end of the study, all animals were sacrificed and the wound tissues removed for analyse to biochemical and histopathological changes. There was a significant increase in the hydroxyproline levels in the skin of the Cur groups. Cur treated wounds were found to heal much faster as indicated by improved rates of inflammatory cells, collagen deposition, angiogenesis, granulation tissue formation and epithelialization which were also confirmed by histopathological and biochemical examinations. Our data also indicate that there is a rise in the expression of proliferating cell nuclear antigen in skin tissues of Cur-treated rats in the Burn group. The results clearly substantiate the beneficial effects of the topical application of Cur in the acceleration of wound healing.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Namik Kemal University, 59030, Tekirdag, Turkey

    Mustafa Kulac

  2. Department of Histology and Embryology, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey

    Cevat Aktas

  3. Department of Biochemistry, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey

    Feti Tulubas

  4. Department of Anatomy, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey

    Ramazan Uygur & Oguz Aslan Ozen

  5. Department of Histology and Embryology, Faculty of Medicine, Istanbul Medeniyet University, Istanbul, Turkey

    Mehmet Kanter

  6. Department of Histology and Embryology, Faculty of Medicine, University of Trakya, Edirne, Turkey

    Mustafa Erboga

  7. Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey

    Mehmet Ceber

  8. Department of Biostatistics, Faculty of Medicine, Namik Kemal University, Tekirdag, Turkey

    Birol Topcu

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  1. Mustafa Kulac
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  2. Cevat Aktas
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  3. Feti Tulubas
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  4. Ramazan Uygur
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  5. Mehmet Kanter
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  6. Mustafa Erboga
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  9. Oguz Aslan Ozen
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Correspondence to Mustafa Kulac.

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Kulac, M., Aktas, C., Tulubas, F. et al. The effects of topical treatment with curcumin on burn wound healing in rats. J Mol Hist 44, 83–90 (2013). https://doi.org/10.1007/s10735-012-9452-9

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  • DOI: https://doi.org/10.1007/s10735-012-9452-9

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