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Lifetime total physical activity and prostate cancer risk: a population-based case–control study in Sweden

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Abstract

The etiologic role of physical activity in prostate cancer development is unclear. We assessed the association between lifetime total physical activity and prostate cancer risk in a Swedish population-based case–control study comprising 1,449 incident prostate cancer cases and 1,118 unaffected population controls. Information regarding physical activity was obtained via a self-administered questionnaire assessing occupational, household, and recreational activity separately at various ages throughout an individual’s lifetime. Clinical data (TNM-classification, Gleason sum and PSA) was obtained from linkage to the National Prostate Cancer Registry. Overall, we observed no association between lifetime total physical activity and prostate cancer risk (odds ratio [OR] = 1.04, 95% confidence interval [CI] = 0.77–1.41 for ≥49.7 vs. <41.9 metabolic equivalent-hours per day). There was a significantly increased risk of prostate cancer in the most active men compared with the least active men in household (OR = 1.44, 95% CI = 1.08–1.92) and recreational physical activity (OR = 1.56, 95% CI = 1.16–2.10). Comparing the most active with the least active men, total physical activity was not associated with either localized disease (OR = 0.95, 95% CI = 0.67–1.34) or advanced disease (OR = 1.19, 95% CI = 0.83–1.71). These findings do not support the hypothesis that physical activity uniformly protects against prostate cancer development.

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Abbreviations

CAPS:

Cancer Prostate in Sweden

MET:

Metabolic equivalent

References

  1. Samad AK, Taylor RS, Marshall T, Chapman MA. A meta-analysis of the association of physical activity with reduced risk of colorectal cancer. Colorectal Dis. 2005;7:204–13. doi:10.1111/j.1463-1318.2005.00747.x.

    Article  PubMed  CAS  Google Scholar 

  2. Monninkhof EM, Elias SG, Vlems FA, van der Tweel I, Schuit AJ, Voskuil DW, et al. Physical activity and breast cancer: a systematic review. Epidemiology. 2007;18:137–57. doi:10.1097/01.ede.0000251167.75581.98.

    Article  PubMed  Google Scholar 

  3. Friedenreich CM, Thune I. A review of physical activity and prostate cancer risk. Cancer Causes Control. 2001;12:461–75. doi:10.1023/A:1011210121901.

    Article  PubMed  CAS  Google Scholar 

  4. Gallus S, Foschi R, Talamini R, Altieri A, Negri E, Franceschi S, et al. Risk factors for prostate cancer in men aged less than 60 years: a case–control study from Italy. Urology. 2007;70:1121–6. doi:10.1016/j.urology.2007.07.020.

    Article  PubMed  Google Scholar 

  5. Lagiou A, Samoli E, Georgila C, Minaki P, Barbouni A, Tzonou A, et al. Occupational physical activity in relation with prostate cancer and benign prostatic hyperplasia. Eur J Cancer Prev. 2008;17:336–9. doi:10.1097/CEJ.0b013e3282f5221e.

    Article  PubMed  Google Scholar 

  6. Pierotti B, Altieri A, Talamini R, Montella M, Tavani A, Negri E, et al. Lifetime physical activity and prostate cancer risk. Int J Cancer. 2005;114:639–42. doi:10.1002/ijc.20783.

    Article  PubMed  CAS  Google Scholar 

  7. Krishnadasan A, Kennedy N, Zhao Y, Morgenstern H, Ritz B. Nested case–control study of occupational physical activity and prostate cancer among workers using a job exposure matrix. Cancer Causes Control. 2008;19:107–14. doi:10.1007/s10552-007-9076-7.

    Article  PubMed  Google Scholar 

  8. Littman AJ, Kristal AR, White E. Recreational physical activity and prostate cancer risk (United States). Cancer Causes Control. 2006;17:831–41. doi:10.1007/s10552-006-0024-8.

    Article  PubMed  Google Scholar 

  9. Patel AV, Rodriguez C, Jacobs EJ, Solomon L, Thun MJ, Calle EE. Recreational physical activity and risk of prostate cancer in a large cohort of U.S. men. Cancer Epidemiol Biomarkers Prev. 2005;14:275–9. doi:10.1158/1055-9965.EPI-04-0583.

    Article  PubMed  Google Scholar 

  10. Zeegers MP, Dirx MJ, van den Brandt PA. Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev. 2005;14:1490–5. doi:10.1158/1055-9965.EPI-04-0771.

    Article  PubMed  Google Scholar 

  11. Moore SC, Peters TM, Ahn J, Park Y, Schatzkin A, Albanes D, et al. Physical activity in relation to total, advanced, and fatal prostate cancer. Cancer Epidemiol Biomarkers Prev. 2008;17:2458–66. doi:10.1158/1055-9965.EPI-08-0403.

    Article  PubMed  Google Scholar 

  12. Sass-Kortsak AM, Purdham JT, Kreiger N, Darlington G, Lightfoot NE. Occupational risk factors for prostate cancer. Am J Ind Med. 2007;50:568–76. doi:10.1002/ajim.20495.

    Article  PubMed  CAS  Google Scholar 

  13. Giovannucci EL, Liu Y, Leitzmann MF, Stampfer MJ, Willett WC. A prospective study of physical activity and incident and fatal prostate cancer. Arch Intern Med. 2005;165:1005–10. doi:10.1001/archinte.165.9.1005.

    Article  PubMed  Google Scholar 

  14. Nilsen TI, Romundstad PR, Vatten LJ. Recreational physical activity and risk of prostate cancer: a prospective population-based study in Norway (the HUNT study). Int J Cancer. 2006;119:2943–7. doi:10.1002/ijc.22184.

    Article  PubMed  CAS  Google Scholar 

  15. Friedenreich CM, McGregor SE, Courneya KS, Angyalfi SJ, Elliott FG. Case–control study of lifetime total physical activity and prostate cancer risk. Am J Epidemiol. 2004;159:740–9. doi:10.1093/aje/kwh106.

    Article  PubMed  CAS  Google Scholar 

  16. Lindmark F, Zheng SL, Wiklund F, Bensen J, Balter KA, Chang B, et al. H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer. J Natl Cancer Inst. 2004;96:1248–54.

    Article  PubMed  CAS  Google Scholar 

  17. Varenhorst E, Garmo H, Holmberg L, Adolfsson J, Damber JE, Hellstrom M, et al. The National Prostate Cancer Register in Sweden 1998–2002: trends in incidence, treatment and survival. Scand J Urol Nephrol. 2005;39:117–23. doi:10.1080/00365590510007793.

    Article  PubMed  Google Scholar 

  18. Chang ET, Smedby KE, Zhang SM, Hjalgrim H, Melbye M, Ost A, et al. Dietary factors and risk of non-hodgkin lymphoma in men and women. Cancer Epidemiol Biomarkers Prev. 2005;14:512–20. doi:10.1158/1055-9965.EPI-04-0451.

    Article  PubMed  Google Scholar 

  19. Norman A, Bellocco R, Bergstrom A, Wolk A. Validity and reproducibility of self-reported total physical activity–differences by relative weight. Int J Obes Relat Metab Disord. 2001;25:682–8. doi:10.1038/sj.ijo.0801597.

    Article  PubMed  CAS  Google Scholar 

  20. Ainsworth BE, Haskell WL, Leon AS, Jacobs DR Jr, Montoye HJ, Sallis JF, et al. Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc. 1993;25:71–80. doi:10.1249/00005768-199301000-00011.

    Article  PubMed  CAS  Google Scholar 

  21. Lee IM. Physical activity and cancer prevention–data from epidemiologic studies. Med Sci Sports Exerc. 2003;35:1823–7. doi:10.1249/01.MSS.0000093620.27893.23.

    Article  PubMed  Google Scholar 

  22. Torti DC, Matheson GO. Exercise and prostate cancer. Sports Med. 2004;34:363–9. doi:10.2165/00007256-200434060-00003.

    Article  PubMed  Google Scholar 

  23. Friedenreich CM, Courneya KS, Bryant HE. The lifetime total physical activity questionnaire: development and reliability. Med Sci Sports Exerc. 1998;30:266–74. doi:10.1097/00005768-199802000-00015.

    PubMed  CAS  Google Scholar 

  24. Platz EA, Leitzmann MF, Michaud DS, Willett WC, Giovannucci E. Interrelation of energy intake, body size, and physical activity with prostate cancer in a large prospective cohort study. Cancer Res. 2003;63:8542–8.

    PubMed  CAS  Google Scholar 

  25. Friedenreich CM, Orenstein MR. Physical activity and cancer prevention: etiologic evidence and biological mechanisms. J Nutr. 2002;132:3456S–64S.

    PubMed  CAS  Google Scholar 

  26. Barnard RJ, Leung PS, Aronson WJ, Cohen P, Golding LA. A mechanism to explain how regular exercise might reduce the risk for clinical prostate cancer. Eur J Cancer Prev. 2007;16:415–21. doi:10.1097/01.cej.0000243851.66985.e4.

    Article  PubMed  CAS  Google Scholar 

  27. Ngo TH, Barnard RJ, Tymchuk CN, Cohen P, Aronson WJ. Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control. 2002;13:929–35. doi:10.1023/A:1021911517010.

    Article  PubMed  Google Scholar 

  28. Hellenius ML, Brismar KE, Berglund BH, de Faire UH. Effects on glucose tolerance, insulin secretion, insulin-like growth factor 1 and its binding protein, IGFBP-1, in a randomized controlled diet and exercise study in healthy, middle-aged men. J Intern Med. 1995;238:121–30.

    Article  PubMed  CAS  Google Scholar 

  29. Haffner SM. Sex hormones, obesity, fat distribution, type 2 diabetes and insulin resistance: epidemiological and clinical correlation. Int J Obes Relat Metab Disord. 2000;24(Suppl 2):S56–8. doi:10.1038/sj/ijo/0801279.

    PubMed  CAS  Google Scholar 

  30. Stattin P, Rinaldi S, Biessy C, Stenman UH, Hallmans G, Kaaks R. High levels of circulating insulin-like growth factor-I increase prostate cancer risk: a prospective study in a population-based nonscreened cohort. J Clin Oncol. 2004;22:3104–12. doi:10.1200/JCO.2004.10.105.

    Article  PubMed  CAS  Google Scholar 

  31. Wolk A, Mantzoros CS, Andersson SO, Bergstrom R, Signorello LB, Lagiou P, et al. Insulin-like growth factor 1 and prostate cancer risk: a population-based, case–control study. J Natl Cancer Inst. 1998;90:911–5. doi:10.1093/jnci/90.12.911.

    Article  PubMed  CAS  Google Scholar 

  32. Heikkila R, Aho K, Heliovaara M, Hakama M, Marniemi J, Reunanen A, et al. Serum testosterone and sex hormone-binding globulin concentrations and the risk of prostate carcinoma: a longitudinal study. Cancer. 1999;86:312–5. doi:10.1002/(SICI)1097-0142(19990715)86:2<312::AID-CNCR15>3.0.CO;2-7.

    Article  PubMed  CAS  Google Scholar 

  33. Reilly M, Pepe M. The relationship between hot-deck multiple imputation and weighted likelihood. Stat Med. 1997;16:5–19. doi:10.1002/(SICI)1097-0258(19970115)16:1<5::AID-SIM469>3.0.CO;2-8.

    Article  PubMed  CAS  Google Scholar 

  34. Orsini N, Bellocco R, Bottai M, Pagano M, Wolk A. Age and temporal trends of total physical activity among Swedish women. Med Sci Sports Exerc. 2006;38:240–5. doi:10.1249/01.mss.0000185086.19220.b3.

    Article  PubMed  Google Scholar 

  35. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171-77, Stockholm, Sweden

    Fredrik Wiklund, Katarina Bälter, Hans-Olov Adami & Henrik Grönberg

  2. Department of Medicine, Unit of Clinical Epidemiology, Karolinska Institutet, 171-76, Stockholm, Sweden

    Ylva Trolle Lageros

  3. Northern California Cancer Center, Fremont, CA, 94538, USA

    Ellen Chang

  4. Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, 94305, USA

    Ellen Chang

  5. Department of Urology, Örebro University Hospital, 701-16, Orebro, Sweden

    Jan-Erik Johansson

  6. Department of Epidemiology, Harvard University, Boston, MA, 02115, USA

    Hans-Olov Adami

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  1. Fredrik Wiklund
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Correspondence to Fredrik Wiklund.

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Wiklund, F., Lageros, Y.T., Chang, E. et al. Lifetime total physical activity and prostate cancer risk: a population-based case–control study in Sweden. Eur J Epidemiol 23, 739–746 (2008). https://doi.org/10.1007/s10654-008-9294-7

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  • DOI: https://doi.org/10.1007/s10654-008-9294-7

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