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The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy

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Abstract

Purpose

Gastric atrophy is a premalignant condition. The aim of this study was to evaluate the correlation between histological and endoscopic findings of atrophy, and to analyze the affecting factors.

Methods

Atrophy was graded by endoscopy, and biopsy was performed in the antrum and body for the diagnosis of atrophy according to the Sydney system in the 1,330 subjects.

Results

Both endoscopic and histological atrophy increased in proportion to age (P < 0.001). The prevalence of endoscopic atrophy was significantly lower than that of histological atrophy especially below 50 years of age. The sensitivity and specificity of endoscopy for the diagnosis of atrophy based on histological diagnosis of atrophy were 61.5 and 57.7% in the antrum, and were 46.8 and 76.4% in the body of the stomach. Multivariate analysis showed that an age <50 (OR 0.38, 95% CI 0.25–0.61) and a PG I/II ratio >3 (OR 0.50, 95% CI 0.35–0.71) in the antrum, and an age < 50 (OR 0.43, 95% CI 0.19–1.00) and a CRP > 5 mg/dl (OR 0.53, 95% CI 0.30–0.94) decreased the sensitivity of the endoscopic diagnosis of atrophy in the body.

Conclusions

A high index of suspicion of gastric atrophy is important in the young age group, and confirmation of the diagnosis by histology is necessary.

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No author has conflicts of interest or financial arrangements that could potentially influence the described research.

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Authors and Affiliations

  1. Department of Internal Medicine, Seoul National University Bundang Hospital, 300 Gumi-dong, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea

    Alisher Eshmuratov, Jong Chun Nah, Nayoung Kim, Byoung Hwan Lee, Min Sik Uhm, Young Soo Park & Dong Ho Lee

  2. Department of Pathology, Seoul National University Bundang Hospital, Seoungnam, Gyeonggi-do, Korea

    Hye Seung Lee & Hee Eun Lee

  3. Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea

    Nayoung Kim, Young Soo Park, Dong Ho Lee, Hyun Chae Jung & In Sung Song

Authors
  1. Alisher Eshmuratov
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  2. Jong Chun Nah
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  3. Nayoung Kim
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  4. Hye Seung Lee
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  7. Min Sik Uhm
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  9. Dong Ho Lee
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Corresponding author

Correspondence to Nayoung Kim.

Additional information

Alisher Eshmuratov and Jong Chun Nah contributed equally to this work.

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Eshmuratov, A., Nah, J.C., Kim, N. et al. The Correlation of Endoscopic and Histological Diagnosis of Gastric Atrophy. Dig Dis Sci 55, 1364–1375 (2010). https://doi.org/10.1007/s10620-009-0891-4

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  • DOI: https://doi.org/10.1007/s10620-009-0891-4

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