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Tumor angiogenesis and vascular normalization: alternative therapeutic targets

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Abstract

Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal vascular network characterized by disorganized, immature and permeable blood vessels, resulting in poorly perfused tumors. The hypoxic microenvironment created by impaired tumor perfusion can promote the selection of more invasive and aggressive tumor cells and can also impede the tumor-killing action of immune cells. Furthermore, abnormal tumor perfusion also reduces the diffusion of chemotherapeutic drugs and radiotherapy efficiency. To fight against this defective phenotype, the normalization of the tumor vasculature has emerged as a new therapeutic strategy. Vascular normalization, by restoring proper tumor perfusion and oxygenation, could limit tumor cell invasiveness and improve the effectiveness of anticancer treatments. In this review, we investigate the mechanisms involved in tumor angiogenesis and describe strategies used to achieve vascular normalization.

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Acknowledgements

This work was supported from an operating grant of the Cancer Research Society of Canada and a New Investigator Award from the Heart and Stroke Foundation of Canada (B.L.).

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  1. Hôpital Maisonneuve-Rosement Research Centre, 5415 Boulevard de l’Assomption, Montreal, QC, Canada

    Claire Viallard & Bruno Larrivée

  2. Department of Ophthalmology, Université de Montréal, Montreal, Canada

    Bruno Larrivée

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Viallard, C., Larrivée, B. Tumor angiogenesis and vascular normalization: alternative therapeutic targets. Angiogenesis 20, 409–426 (2017). https://doi.org/10.1007/s10456-017-9562-9

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