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Vitamin D in der Reproduktionsmedizin

Vitamin D in reproductive medicine

  • Leitthema
  • Published:
Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Hintergrund

Experimentelle Daten belegen den Einfluss von 1,25-Dihydroxy-Vitamin D3 auf die Reproduktionsorgane. Beobachtungsstudien weisen auf eine verminderte Fertilität bei Vitamin-D-Mangel hin.

Fragestellung

Einfluss von Vitamin D auf die Fertilität und Schwangerschaftsrate.

Material und Methoden

Auswertung von Originalarbeiten, Übersichtsarbeiten und Metaanalysen, Diskussion der Ergebnisse.

Ergebnisse

Die Beobachtungsstudien liefern kontroverse Ergebnisse hinsichtlich des Zusammenhangs zwischen Vitamin-D-Status und Fertilität. Gute kontrollierte Studien fehlen. Der Effekt einer Vitamin-D-Supplementation auf die metabolischen Veränderungen beim Syndrom polyzystischer Ovarien ist eher schwach.

Schlussfolgerung

Die Evidenz für eine Supplementation gesunder Frauen mit Vitamin D erscheint schwach. Ein Vitamin-D-Mangel sollte allerdings ausgeglichen werden.

Abstract

Background

Experimental data give evidence that 1,25-dihydroxy vitamin D3 modulates the function of reproductive organs. Observational studies suggest that vitamin D deficiency is associated with reduced fertility.

Objectives

Influence of vitamin D on fertility and pregnancy rate.

Methods

Analysis of original studies, reviews, and meta-analyses.

Results

Observational studies show controversial results regarding the association between vitamin D status and fertility. Good randomized trials are missing. The effect of vitamin D supplementation on metabolic disturbances in polycystic ovary syndrome is weak.

Conclusion

The evidence for vitamin D supplementation in healthy women is weak. However, a vitamin D deficiency should be corrected.

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Authors and Affiliations

  1. Praxis für Innere Medizin und Endokrinologie/Diabetologie, Salinenstraße 8, 83435, Bad Reichenhall, Deutschland

    Stephan H. Scharla

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Correspondence to Stephan H. Scharla.

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S.H. Scharla gibt an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine vom Autor durchgeführten Studien an Menschen oder Tieren.

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P. Stute, Bern

G. Griesinger, Lübeck

T. Strowitzki, Heidelberg

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Scharla, S.H. Vitamin D in der Reproduktionsmedizin. Gynäkologische Endokrinologie 17, 16–19 (2019). https://doi.org/10.1007/s10304-018-0235-6

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  • DOI: https://doi.org/10.1007/s10304-018-0235-6

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