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Autonomic dysfunction, immune regulation, and multiple sclerosis

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Abstract

Objective

To review existing evidence regarding interactions between the autonomic nervous system and the immune system functions in multiple sclerosis.

Methods

We reviewed the literature regarding new insights linking autonomic dysfunction to immune deregulation in multiple sclerosis, with particular focus on the specific influence of sympathetic and parasympathetic dysfunction on inflammatory and neurodegenerative processes.

Results

Autonomic dysfunction is common in multiple sclerosis, representing a significant cause of disability. Several connections between pathologic immune pathways and the autonomic nervous system function were found.

Conclusions

Autonomic dysfunction may enhance inflammatory and neurodegenerative pathways that are of major importance in multiple sclerosis. Autonomic dysfunction can present with highly variable manifestations. Sympathetic and parasympathetic dysfunction displays different patterns in multiple sclerosis, with specific impact on inflammation and neurodegeneration.

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Authors and Affiliations

  1. Department of Clinical Neurological Sciences, London Health Sciences Centre, Western University, London, ON, Canada

    Juan Manuel Racosta & Kurt Kimpinski

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  1. Juan Manuel Racosta
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  2. Kurt Kimpinski
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Correspondence to Juan Manuel Racosta.

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On behalf of all authors, the corresponding author states that there is no conflict of interest.

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Racosta, J.M., Kimpinski, K. Autonomic dysfunction, immune regulation, and multiple sclerosis. Clin Auton Res 26, 23–31 (2016). https://doi.org/10.1007/s10286-015-0325-7

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  • DOI: https://doi.org/10.1007/s10286-015-0325-7

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