Abstract
We report the case of a 51-year-old woman who showed elevation of serum carcinoembryonic antigen (CEA) level 14 months after chemoradiation therapy for her cervical esophageal cancer. Close examination demonstrated that the patient was suffering from hypothyroidism probably due to the chemoradiation therapy. The serum CEA level decreased after starting supplementary treatment with oral levothyroxine. The exact mechanism underlying the elevated level of CEA observed in a patient with hypothyroidism is unclear. However, we should be aware of the possibility of transient elevation of CEA affected by thyroid function in patients after radiation therapy for head and neck cancer.
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References
Jereczek-Fossaa BA, Alterio D, Jassem J et al (2004) Radiotherapy-induced thyroid disorders. Cancer Treat Rev 30:369–384
Koepke JA (1992) Molecular marker test standardization. Cancer 69:1578–1581
Duffy MJ (2001) Carcinoembryonic antigen as a marker for colorectal cancer: is it clinically useful? Clin Chem 47:624–630
Sobin LH, Wittekind CH (2002) Oesophagus. In: Sobin LH, Wittekind CH (eds) TNM classification of malignant tumours, 6th edn. Wiley, New York, pp 60–64
Sasamoto R, Sakai K, Inakoshi H et al (2007) Long-term results of chemoradiotherapy for locally advanced esophageal cancer, using daily low-dose 5-fluorouracil and cis-diammine-dichloro-platinum (CDDP). Int J Clin Oncol 12:25–30
Jameson JL, Weetman AP (2005) Disorders of the thyroid gland. In: Kasper DL, Braunwald E, Fauci AS et al (eds) Harrison’s principles of internal medicine, 16th edn. McGraw-Hill, New York, pp 2104–2113
Tulloch BR (1974) Lipid changes in thyroid disease: the effect of thyroxine and analogues. Proc R Soc Med 67:670–671
Hancock SI, McDougall IR, Constine LS (1995) Thyroid abnormalities after therapeutic external radiation. Int J Radiat Oncol Biol Phys 31:1165–1170
Emami B, Lyman J, Brown A et al (1991) Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 21:109–122
Kato H, Wakasugi H, Tsutsumi T et al (1991) A case of transient elevation of the serum carcinoembryonic antigen and associated with severe malnutrition and low T3, T4 syndrome. Fukuoka Igaku Zasshi 82:387–390
Takahashi N, Shimada T, Ishibashi Y et al (2007) Transient elevation of serum tumor markers in a patient with hypothyroidism. Am J Med Sci 333:387–389
Bertola G, Balza G, Oriani A et al (2004) Elevated concentration of serum carcinoembryonic antigen in hypothyroidism. Recenti Prog Med 95:204–206
Amino N, Kuro R, Yabu Y et al (1981) Elevated levels of circulating carcinoembryonic antigen in hypothyroidism. J Clin Endocrinol Metab 52:457–462
Hashimoto T, Matsubara F (1989) Changes in the tumor marker concentration in female patients with hyper-, eu-, and hypothyroidism. Endocrinol Jpn 36:873–879
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Kawaguchi, G., Abe, E., Sasamoto, R. et al. Elevation of serum carcinoembryonic antigen level in a patient with hypothyroidism after radiation therapy for cervical esophageal cancer. Int J Clin Oncol 15, 104–108 (2010). https://doi.org/10.1007/s10147-009-0005-5
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DOI: https://doi.org/10.1007/s10147-009-0005-5