Abstract
To provide recent statistics on worldwide gout epidemiology. Current and prediction data on gout epidemiology were retrieved from the Global Health Data Exchange (GHDx) registry and from the World Health Organization (WHO) database on projected mortality. Overall, 7.44 million cases of gout have been estimated around the world in 2017 (incidence, 0.097%), with a prevalence of 41.22 million cases (0.54%), and causing 1.28 million DALYs (0.051% of all DALYs). Gout incidence, prevalence, and health loss considerably increased during the last 25 years and are all higher in men than in women. The burden of gout increases linearly with aging, until the age of 64 years, and is correlated with socio-demographic index (SDI), with incident risk of gout > 3-fold higher in high than in low SDI regions. Projections suggest that gout mortality may increase by 55% in 2060. The epidemiologic burden of gout remains high around the world, especially in men and in high SDI countries, with a trend that is unlikely to reverse soon.
Key Points • A significant association can be found between gout and socioeconomic status. • Projections suggest that gout mortality may increase by 55% in 2060. • The epidemiologic burden of gout remains high around the world. |
References
Fischer A, Cloutier M, Goodfield J, Borrelli R, Marvin D, Dziarmaga A (2017) The direct economic burden of gout in an elderly Canadian population. J Rheumatol 44:95–101
Elfishawi MM, Zleik N, Kvrgic Z, Michet CJ Jr, Crowson CS, Matteson EL, Bongartz T (2018) The rising incidence of gout and the increasing burden of comorbidities: a population-based study over 20 years. J Rheumatol 45:574–579
Cea Soriano L, Rothenbacher D, Choi HK, García Rodríguez LA (2011) Contemporary epidemiology of gout in the UK general population. Arthritis Res Ther 13:R39
Pisaniello HL, Lester S, Gonzalez-Chica D, Stocks N, Longo M, Sharplin GR, Dal Grande E, Gill TK, Whittle SL, Hill CL (2018) Gout prevalence and predictors of urate-lowering therapy use: results from a population-based study. Arthritis Res Ther 20:143
Roddy E, Choi HK (2014) Epidemiology of gout. Rheum Dis Clin N Am 40:155–175
Kuo CF, Grainge MJ, Zhang W, Doherty M (2015) Global epidemiology of gout: prevalence, incidence and risk factors. Nat Rev Rheumatol 11:649–662
Pascart T, Lioté F (2019) Gout: state of the art after a decade of developments. Rheumatology (Oxford) 58:27–44
Institute for Health Metrics and Evaluation Global health data exchange. Available at: http://ghdx.healthdata.org/gbd-results-tool. Last accessed, July 31, 2019
Xia Y, Wu Q, Wang H, Zhang S, Jiang Y, Gong T, Xu X, Chang Q, Niu K, Zhao Y (2019) Global, regional and national burden of gout, 1990-2017: a systematic analysis of the Global Burden of Disease Study. Rheumatology (Oxford). https://doi.org/10.1093/rheumatology/kez476
GBD (2017) Disease and Injury Incidence and Prevalence Collaborators (2018) Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392:1789–1858
World Health Organization Projections of mortality and causes of death, 2016 to 2060. Available at: https://www.who.int/healthinfo/global_burden_disease/projections/en/. Last access: July 31, 2019
Golenbiewski J, Keenan RT (2019) Moving the needle: improving the care of the gout patient. Rheumatol Ther 6:179–193
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Mattiuzzi, C., Lippi, G. Recent updates on worldwide gout epidemiology. Clin Rheumatol 39, 1061–1063 (2020). https://doi.org/10.1007/s10067-019-04868-9
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DOI: https://doi.org/10.1007/s10067-019-04868-9