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Extra-articular manifestations in psoriatic arthritis patients

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Abstract

Psoriatic arthritis (PsA) is an inflammatory rheumatic disorder, associated with skin and/or nail psoriasis. It has been included in the spondyloarthropathies (SpA) group, with which it shares clinical, radiologic, and serologic features and familial and genetic relationship. Inclusion of disease among SpA is also based on their striking points of similarity for extra-articular manifestations (EAMs). The aim of study was to describe the EAMs in patients with PsA, evaluating the prevalence and clinical features associated with established and early PsA. The study was a retrospective analysis of case records of 387 PsA patients. Data recorded were demographic data, disease properties, laboratory tests, drug use, and presence of EAMs. Of 387 PsA patients, 190 have shown EAMs: 33.16 % had bowel involvement, 32.63 % ocular, 28.42 % cardiovascular, 25.79 % urogenital, 8.42 % skin (excluding psoriasis), 1.05 % pulmonary, and 0.53 % renal. A higher prevalence of EAMs was found in axial subset (p < 0.0001) and in established PsA patients (p = 0.03). The disease activity in PsA patients with EAMs was significantly higher (p < 0.0005). Smoker PsA patients had a significantly higher prevalence of EAMs than nonsmoker PsA patients (p < 0.0005). EAMs in PsA patients are common than expected and frequently associated with established form and axial subset. EAMs were more frequent in male gender, and the contemporary presence of male gender and axial subset showed a higher risk to develop EAMs. EAMS were more frequent in patients with a long disease duration and active disease. Moreover, these results suggest that in PsA patients, an initial checkup and a regular screening for EAMs are requested to ensure an appropriate management.

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Conflict of interest

All the authors revised and approved the present version of this manuscript. No funding and economic support have been received to perform this study. The authors did not receive specific funding for the preparation of this manuscript. During the last 5 years, they served on advisory boards and received honoraria and grants for research unrelated to this study.

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Authors and Affiliations

  1. Rheumatology Research Unit, University Federico II, Naples, Italy

    Rosario Peluso, Maria Vitiello & Vincenzo Bruner

  2. Regional Reference Center for Coagulation Disorders, University Federico II, Naples, Italy

    Matteo Nicola Dario Di Minno

  3. Department of Clinical Medicine and Surgery, University Federico II, Via Sergio Pansini 5, 80131, Naples, Italy

    Rosario Peluso, Maria Vitiello, Vincenzo Bruner, Gelsy Lupoli & Matteo Nicola Dario Di Minno

  4. Rheumatology and Rehabilitation Research Unit, “Salvatore Maugeri” Foundation, Telese Terme, Benevento, Italy

    Salvatore Iervolino

Authors
  1. Rosario Peluso
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  2. Salvatore Iervolino
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  4. Vincenzo Bruner
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  5. Gelsy Lupoli
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  6. Matteo Nicola Dario Di Minno
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Correspondence to Rosario Peluso.

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Author contributions

Dr. Rosario Peluso and Dr. Matteo Nicola Dario Di Minno had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Study design: Rosario Peluso, Matteo Nicola Dario Di Minno, Salvatore Iervolino, and Gelsy Lupoli.

Acquisition of data: Salvatore Iervolino, Maria Vitiello, and Vincenzo Bruner.

Analysis and interpretation of data: Rosario Peluso, Matteo Nicola Dario Di Minno, and Gelsy Lupoli.

Manuscript preparation: Rosario Peluso, Matteo Nicola Dario Di Minno, and Maria Vitiello.

Statistical analysis: Matteo Nicola Dario Di Minno.

Rosario Peluso and Salvatore Iervolino equally contributed to the paper.

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Peluso, R., Iervolino, S., Vitiello, M. et al. Extra-articular manifestations in psoriatic arthritis patients. Clin Rheumatol 34, 745–753 (2015). https://doi.org/10.1007/s10067-014-2652-9

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  • DOI: https://doi.org/10.1007/s10067-014-2652-9

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