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The initial presentation of systemic lupus erythematosis with aplastic anemia successfully treated with rituximab

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Abstract

Hematologic disorders are common in autoimmune diseases. First presentation of systemic lupus erythematosis with aplastic anemia is extremely rare. We report a patient with the diagnosis of secondary aplastic anemia associated with lupus. All routine medications were not effective. She received Rituximab and her response was satisfactory. Her hematologic parameters were within normal range until last follow-up, six months after therapy was initiated with Rituximab. Review of literature displayed 23 cases of acquired aplastic anemia secondary to systemic lupus erythematosis; however, this is the first time the new drug therapy was used for the treatment.

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Acknowledgments

The authors thank the patient’s family for their cooperation. We would also like to express our gratitude to Dr. Mohsen Reza Haidari for reviewing and meticulous extensive editing of the English text.

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Authors and Affiliations

  1. Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Islamic Republic of Iran

    Gholam-Hossein Alishiri, Noushin Bayat & Ali-Reza Saadat

  2. Health Research Center, Baqiyatallah University of Medical Sciences, Mollasadra St., Vanak Square, Islamic Republic of Iran

    Amin Saburi

  3. Shahid Beheshti University of Medical Sciences, Tehran, Islamic Republic of Iran

    Ehsan Saburi

Authors
  1. Gholam-Hossein Alishiri
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  2. Amin Saburi
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  3. Noushin Bayat
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  4. Ali-Reza Saadat
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  5. Ehsan Saburi
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Correspondence to Amin Saburi.

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Alishiri, GH., Saburi, A., Bayat, N. et al. The initial presentation of systemic lupus erythematosis with aplastic anemia successfully treated with rituximab. Clin Rheumatol 31, 381–384 (2012). https://doi.org/10.1007/s10067-011-1878-z

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  • DOI: https://doi.org/10.1007/s10067-011-1878-z

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