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Absence of antibody to cyclic citrullinated peptide in sera of non-arthritic patients with chronic hepatitis B virus infection

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Abstract

The objective of this study was to investigate if antibody to cyclic citrullinated peptide (anti-CCP) is detected in sera of patients with chronic hepatitis B virus (HBV) infection. Serum anti-CCP and IgA, IgG, and IgM rheumatoid factor (RF) isotypes were measured by enzyme-linked immunosorbent assay on 176 non-arthritic patients with HBV infection. IgA RF, IgG RF, and IgM RF were detectable in 29.5, 21, and 18.8% of the tested sera, respectively, with a total seropositivity rate of 42.7%. Marginally elevated anti-CCP was detected in one patient (0.6%). By regression analysis, there was no statistically significant association between the serum levels of anti-CCP and serum IgA, IgG, or IgM RF (R 2 = 0.033, with respective p values of 0.224, 0.297, and 0.334). In conclusion, anti-CCP was rarely detected in non-arthritic patients with HBV infection in contrast to RF. Thus, testing for anti-CCP may be a useful tool for the diagnosis of rheumatoid arthritis in this population.

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Authors and Affiliations

  1. Department of Internal Medicine and Institute of Health Science, College of Medicine, Gyeongsang National University, Jinju, Republic of Korea

    Sang-il Lee

  2. Division of Rheumatology, Department of Internal Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, Jeonju, Republic of Korea

    Wan Hee Yoo & Hee Jin Yun

  3. Department of Laboratory Medicine, Chonbuk National University Medical School and Research Institute of Clinical Medicine, 634-18, Keumamdong, Deokjingu, Jeonju, Jeonbuk, 561-712, Republic of Korea

    Dal Sik Kim, Hye Soo Lee, Sam Im Choi & Yong Gon Cho

  4. Department of Internal Medicine, College of Medicine, Catholic University, Seoul, Republic of Korea

    Ji An Hur

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  1. Sang-il Lee
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  2. Wan Hee Yoo
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Correspondence to Yong Gon Cho.

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Lee, Si., Yoo, W.H., Yun, H.J. et al. Absence of antibody to cyclic citrullinated peptide in sera of non-arthritic patients with chronic hepatitis B virus infection. Clin Rheumatol 26, 1079–1082 (2007). https://doi.org/10.1007/s10067-006-0451-7

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  • DOI: https://doi.org/10.1007/s10067-006-0451-7

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