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Effect of lifestyle, gender and age on collagen formation and degradation

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Abstract

Historically, inappropriate lifestyle with an inadequate dietary intake of vitamin C has been associated with poor wound healing as a clinical manifestation of scurvy. In modern times, clinical evidence produced over the past few decades indicates that a modern lifestyle factor, such as smoking, together with biologic characteristics, like old age and male gender, are risk factors for abdominal wall hernia and recurrence. The pathologic pathways for these clinical observations are unclear. Yet, evidence from animal and human studies suggests that these exogenous and endogenous factors may have a negative impact on collagen metabolism, enhancing degradation and impairing formation.

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References

  1. Walter R, Robins B (1974) A voyage round the world in the years MDC–MCXL, I, II, III, IV by George Anson. Oxford University Press, London, pp 106–107

    Google Scholar 

  2. Stewart CP, Guthrie D (eds) (1953) Lind’s treatise on scurvy, a bicentennial volume containing a reprint of the first edition of A treatise on scurvy by James Lind, MD with additional notes. Edinburgh University Press, Edinburgh, pp 113–126

    Google Scholar 

  3. Hirschmann JV, Raugi GJ (1999) Adult scurvy. J Am Acad Dermatol 41(6):895–906

    Article  PubMed  CAS  Google Scholar 

  4. Sorensen LT, Jorgensen LN, Gottrup F (2003) Biochemical aspects of abdominal wall hernia and recurrence. In: Fitzgibbons RJ Jr, Greenburg AG (eds) Nyhus and Condon’s hernia, 5th edn. Lippincott William & Wilkins, Philadelphia, Pennsylvania, pp 9–16

    Google Scholar 

  5. Bevelaqua FA, Hasselbacher P, Schumacher HR (1976) Scurvy and hemarthrosis. JAMA 235(17):1874–1876

    Article  PubMed  CAS  Google Scholar 

  6. Alberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P (2002) Molecular biology of the cell, 4th edn. Garland Science, New York

    Google Scholar 

  7. Lindholt JS, Jorgensen B, Klitgaard NA, Henneberg EW (2003) Systemic levels of cotinine and elastase, but not pulmonary function, are associated with the progression of small abdominal aortic aneurysms. Eur J Vasc Endovasc Surg 26(4):418–422

    Article  PubMed  CAS  Google Scholar 

  8. van Laarhoven CJ, Borstlap AC, Berge Henegouwen DP, Palmen FM, Verpalen MC, Schoemaker MC (1993) Chronic obstructive pulmonary disease and abdominal aortic aneurysms. Eur J Vasc Surg 7(4):386–390

    Article  PubMed  Google Scholar 

  9. Janoff A (1985) Elastases and emphysema. Current assessment of the protease-antiprotease hypothesis. Am Rev Respir Dis 132(2):417–433

    PubMed  CAS  Google Scholar 

  10. Cannon DJ, Read RC (1981) Metastatic emphysema: a mechanism for acquiring inguinal herniation. Ann Surg 194(3):270–278

    Article  PubMed  CAS  Google Scholar 

  11. Sorensen LT, Hemmingsen U, Kallehave F, Wille-Jorgensen P, Kjaergaard J, Moller LN, Jorgensen T (2005) Risk factors for tissue and wound complications in gastrointestinal surgery. Ann Surg 241(4):654–658

    Article  PubMed  Google Scholar 

  12. Sorensen LT, Jorgensen T, Kirkeby LT, Skovdal J, Vennits B, Wille-Jorgensen P (1999) Smoking and alcohol abuse are major risk factors for anastomotic leakage in colorectal surgery. Br J Surg 86(7):927–931

    Article  PubMed  CAS  Google Scholar 

  13. Peivandi AA, Kasper-Konig W, Quinkenstein E, Loos AH, Dahm M (2003) Risk factors influencing the outcome after surgical treatment of complicated deep sternal wound complications. Cardiovasc Surg 11(3):207–212

    Article  PubMed  CAS  Google Scholar 

  14. Levin L, Schwartz-Arad D (2005) The effect of cigarette smoking on dental implants and related surgery. Implant Dent 14(4):357–361

    PubMed  Google Scholar 

  15. Spear SL, Ducic I, Cuoco F, Hannan C (2005) The effect of smoking on flap and donor-site complications in pedicled TRAM breast reconstruction. Plast Reconstr Surg 116(7):1873–1880

    Article  PubMed  CAS  Google Scholar 

  16. Moller AM, Pedersen T, Villebro N, Munksgaard A (2003) Effect of smoking on early complications after elective orthopaedic surgery. J Bone Joint Surg Br 85(2):178–181

    Article  PubMed  Google Scholar 

  17. Sorensen LT, Hemmingsen UB, Kirkeby LT, Kallehave F, Jorgensen LN (2005) Smoking is a risk factor for incisional hernia. Arch Surg 140(2):119–123

    Article  PubMed  Google Scholar 

  18. Junge K, Rosch R, Klinge U, Schwab R, Peiper C, Binnebosel M, Schenten F, Schumpelick V (2006) Risk factors related to recurrence in inguinal hernia repair: a retrospective analysis. Hernia 10(4):309–315

    Article  PubMed  CAS  Google Scholar 

  19. Sorensen LT, Friis E, Jorgensen T, Vennits B, Andersen BR, Rasmussen GI, Kjaergaard J (2002) Smoking is a risk factor for recurrence of groin hernia. World J Surg 26(4):397–400

    Article  PubMed  Google Scholar 

  20. Abrahamson J (1998) Etiology and pathophysiology of primary and recurrent groin hernia formation. Surg Clin North Am 78(6):953–972

    Article  PubMed  CAS  Google Scholar 

  21. Bielecki K, Pulawski R (1988) Is cigarette smoking a causative factor in the development of inguinal hernia? (in Polish). Pol Tyg Lek 43(30):974–976

    PubMed  CAS  Google Scholar 

  22. Knuutinen A, Kokkonen N, Risteli J, Vahakangas K, Kallioinen M, Salo T, Sorsa T, Oikarinen A (2002) Smoking affects collagen synthesis and extracellular matrix turnover in human skin. Br J Dermatol 146(4):588–594

    Article  PubMed  CAS  Google Scholar 

  23. Jorgensen LN, Kallehave F, Christensen E, Siana JE, Gottrup F (1998) Less collagen production in smokers. Surgery 123(4):450–455

    PubMed  CAS  Google Scholar 

  24. Lahmann C, Bergemann J, Harrison G, Young AR (2001) Matrix metalloproteinase-1 and skin ageing in smokers. Lancet 357(9260):935–936

    Article  PubMed  CAS  Google Scholar 

  25. Sorensen LT, Nielsen HB, Kharazmi A, Gottrup F (2004) Effect of smoking and abstention on oxidative burst and reactivity of neutrophils and monocytes. Surgery 136(5):1047–1053

    Article  PubMed  Google Scholar 

  26. Wong LS, Martins-Green M (2004) Firsthand cigarette smoke alters fibroblast migration and survival: implications for impaired healing. Wound Repair Regen 12(4):471–484

    Article  PubMed  Google Scholar 

  27. Yin L, Morita A, Tsuji T (2000) Alterations of extracellular matrix induced by tobacco smoke extract. Arch Dermatol Res 292(4):188–194

    Article  PubMed  CAS  Google Scholar 

  28. Lykkesfeldt J, Loft S, Nielsen JB, Poulsen HE (1997) Ascorbic acid and dehydroascorbic acid as biomarkers of oxidative stress caused by smoking. Am J Clin Nutr 65(4):959–963

    PubMed  CAS  Google Scholar 

  29. Richardson D (1987) Effects of tobacco smoke inhalation on capillary blood flow in human skin. Arch Environ Health 42(1):19–25

    Article  PubMed  CAS  Google Scholar 

  30. Jensen JA, Goodson WH, Williams H, Hunt TK (1991) Cigarette smoking decreases tissue oxygen. Arch Surg 126(9):1131–1134

    PubMed  CAS  Google Scholar 

  31. Sorensen LT, Jorgensen LN, Zillmer R, Vange J, Hemmingsen U, Gottrup F (2006) Transdermal nicotine patch enhances type I collagen synthesis in abstinent smokers. Wound Repair Regen 14(3):247–251

    Article  PubMed  Google Scholar 

  32. Jacobi J, Jang JJ, Sundram U, Dayoub H, Fajardo LF, Cooke JP (2002) Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Am J Pathol 161(1):97–104

    PubMed  CAS  Google Scholar 

  33. Lykkesfeldt J, Christen S, Wallock LM, Chang HH, Jacob RA, Ames BN (2000) Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. Am J Clin Nutr 71(2):530–536

    PubMed  CAS  Google Scholar 

  34. Vidovic D, Jurisic D, Franjic BD, Glavan E, Ledinsky M, Bekavac-Beslin M (2006) Factors affecting recurrence after incisional hernia repair. Hernia 10(4):322–325

    Article  PubMed  CAS  Google Scholar 

  35. Sauerland S, Korenkov M, Kleinen T, Arndt M, Paul A (2004) Obesity is a risk factor for recurrence after incisional hernia repair. Hernia 8(1):42–46

    Article  PubMed  CAS  Google Scholar 

  36. Dindo D, Muller MK, Weber M, Clavien PA (2003) Obesity in general elective surgery. Lancet 361(9374):2032–2035

    Article  PubMed  Google Scholar 

  37. Peacock EE Jr, Madden JW (1974) Studies on the biology and treatment of recurrent inguinal hernia. II. Morphological changes. Ann Surg 179(5):567–571

    Article  PubMed  Google Scholar 

  38. Conner WT, Peacock EE Jr (1973) Some studies on the etiology of inguinal hernia. Am J Surg 126(6):732–735

    Article  PubMed  CAS  Google Scholar 

  39. McArdle G (1997) Is inguinal hernia a defect in human evolution and would this insight improve concepts for methods of surgical repair? [see comments]. Clin Anat 10(1):47–55

    Article  PubMed  CAS  Google Scholar 

  40. Bucknall TE, Cox PJ, Ellis H (1982) Burst abdomen and incisional hernia: a prospective study of 1129 major laparotomies. Br Med J (Clin Res Ed) 284(6320):931–933

    Article  CAS  Google Scholar 

  41. Carlson MA, Ludwig KA, Condon RE (1995) Ventral hernia and other complications of 1,000 midline incisions. South Med J 88(4):450–453

    PubMed  CAS  Google Scholar 

  42. Raffetto JD, Cheung Y, Fisher JB, Cantelmo NL, Watkins MT, Lamorte WW, Menzoian JO (2003) Incision and abdominal wall hernias in patients with aneurysm or occlusive aortic disease. J Vasc Surg 37(6):1150–1154

    Article  PubMed  Google Scholar 

  43. Adye B, Luna G (1998) Incidence of abdominal wall hernia in aortic surgery. Am J Surg 175(5):400–402

    PubMed  CAS  Google Scholar 

  44. Lehnert B, Wadouh F (1992) High coincidence of inguinal hernias and abdominal aortic aneurysms. Ann Vasc Surg 6(2):134–137

    Article  PubMed  CAS  Google Scholar 

  45. Cannon DJ, Casteel L, Read RC (1984) Abdominal aortic aneurysm, Leriche’s syndrome, inguinal herniation, and smoking. Arch Surg 119(4):387–389

    PubMed  CAS  Google Scholar 

  46. Rullier E, Laurent C, Garrelon JL, Michel P, Saric J, Parneix M (1998) Risk factors for anastomotic leakage after resection of rectal cancer. Br J Surg 85(3):355–358

    Article  PubMed  CAS  Google Scholar 

  47. Carlson MA (1997) Acute wound failure. Surg Clin North Am 77(3):607–636

    Article  PubMed  CAS  Google Scholar 

  48. Penninckx FM, Poelmans SV, Kerremans RP, Beckers JP (1979) Abdominal wound dehiscence in gastroenterological surgery. Ann Surg 189(3):345–352

    Article  PubMed  CAS  Google Scholar 

  49. Castelo-Branco C, Pons F, Gratacos E, Fortuny A, Vanrell JA, Gonzalez-Merlo J (1994) Relationship between skin collagen and bone changes during aging. Maturitas 18(3):199–206

    Article  PubMed  CAS  Google Scholar 

  50. Fujii K, Tanzer ML (1974) Age-related changes in the reducible crosslinks of human tendon collagen. FEBS Lett 43(3):300–302

    Article  PubMed  CAS  Google Scholar 

  51. Wagh PV, Leverich AP, Sun CN, White HJ, Read RC (1974) Direct inguinal herniation in men: a disease of collagen. J Surg Res 17(6):425–433

    Article  PubMed  CAS  Google Scholar 

  52. Ashcroft GS, Horan MA, Ferguson MW (1997) Aging is associated with reduced deposition of specific extracellular matrix components, an upregulation of angiogenesis, and an altered inflammatory response in a murine incisional wound healing model. J Invest Dermatol 108(4):430–437

    Article  PubMed  CAS  Google Scholar 

  53. Lenhardt R, Hopf HW, Marker E, Akca O, Kurz A, Scheuenstuhl H, Sessler DI (2000) Perioperative collagen deposition in elderly and young men and women. Arch Surg 135(1):71–74

    Article  PubMed  CAS  Google Scholar 

  54. Jorgensen LN, Sorensen LT, Kallehave F, Vange J, Gottrup F (2002) Premenopausal women deposit more collagen than men during healing of an experimental wound. Surgery 131(3):338–343

    Article  PubMed  Google Scholar 

  55. Gniadecki R, Wyrwas B, Kabala A, Matecka J (1996) Impairment of granulation tissue formation after menopause. J Endocrinol Invest 19(4):215–218

    PubMed  CAS  Google Scholar 

  56. Affinito P, Palomba S, Sorrentino C, Di Carlo C, Bifulco G, Arienzo MP, Nappi C (1999) Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas 33(3):239–247

    Article  PubMed  CAS  Google Scholar 

  57. Ashcroft GS, Greenwell-Wild T, Horan MA, Wahl SM, Ferguson MW (1999) Topical estrogen accelerates cutaneous wound healing in aged humans associated with an altered inflammatory response. Am J Pathol 155(4):1137–1146

    PubMed  CAS  Google Scholar 

  58. Tarlton JF, Vickery CJ, Leaper DJ, Bailey AJ (1997) Postsurgical wound progression monitored by temporal changes in the expression of matrix metalloproteinase-9. Br J Dermatol 137(4):506–516

    Article  PubMed  CAS  Google Scholar 

  59. Ashcroft GS, Horan MA, Herrick SE, Tarnuzzer RW, Schultz GS, Ferguson MW (1997) Age-related differences in the temporal and spatial regulation of matrix metalloproteinases (MMPs) in normal skin and acute cutaneous wounds of healthy humans. Cell Tissue Res 290(3):581–591

    Article  PubMed  CAS  Google Scholar 

  60. Ashcroft GS, Herrick SE, Tarnuzzer RW, Horan MA, Schultz GS, Ferguson MW (1997) Human ageing impairs injury-induced in vivo expression of tissue inhibitor of matrix metalloproteinases (TIMP)-1 and -2 proteins and mRNA. J Pathol 183(2):169–176

    Article  PubMed  CAS  Google Scholar 

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Acknowledgements

The author is indebted to Dr. Lars Nannestad Jorgensen, whose excellent work has served as an immense source of inspiration.

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  1. Department of Surgery, Bispebjerg Hospital, 2400, Copenhagen NV, Denmark

    Lars Tue Sørensen

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  1. Lars Tue Sørensen
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Correspondence to Lars Tue Sørensen.

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Sørensen, L.T. Effect of lifestyle, gender and age on collagen formation and degradation. Hernia 10, 456–461 (2006). https://doi.org/10.1007/s10029-006-0143-x

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