Abstract
Objective
In a recent review, the prevalence of comorbid psychiatric disorders in non-treated adolescents and young adults with substance use disorders (SUD) in the general population was summarized. This review looks into the prevalence of psychiatric comorbidity in adolescents and young adults treated for SUD.
Method
A computerized literature search was conducted resulting in ten eligible studies.
Results
The prevalence of comorbid psychiatric disorders varied from 61% to 88%. Externalizing disorders, especially Conduct Disorder (CD), were most consistently linked to SUD in treatment seeking adolescents. Girls are distinguished by their high rate of comorbid internalizing disorders.
Conclusions
Comparison with data from community and juvenile justice studies shows an ascending trend of comorbidity rates of externalizing disorders from community to clinical and finally to juvenile justice samples. It seems that young addicts with comorbid disorders are at high risk of ending up in the juvenile justice system.
Similar content being viewed by others
References
Abram KM, Teplin LA, McClelland, Dulcan MK (2003) Comorbid Psychiatric Disorders in Youth in Juvnile Detention. Arch Gen Psychiatry 60:1097–1108
Armstrong TD, Costello EJ (2002) Community studies on adolescent substance use abuse or dependence and psychiatric comorbidity. J Consult Clin Psychol 70:1224–1239
Banaschewski T, Brandeis D, Heinrich H, Albrecht B, Brunner E, Rothenberger A (2003) Association of ADHD and conduct disorder – brain electrical evidence for the existence of a distinct subtype. J Child Psychol Psychiatry 44:356–376
Wise BK, Cuffe SP, Fischer T (2001) Dual diagnosis and successful participation of adolescents in substance abuse treatment. J Subst Abuse Treat 21:161–165
Biederman J, Willens T, Mick E, Faraone SV, Spencer T (1998) Does attention-deficit hyperactivity disorder impact the developmental course of drug and alcohol abuse and dependence? Biol Psychiatry 44:269–273
Biederman J, Willens T, Mick E, Faraone SV, Weber W, Curtis S, Thrornell A, Pfister K, Jetton JG, Soriano J (1997) Is ADHD a risk factor for psychoactive substance use disorders: Findings from a four-year prospective follow-up study. J Am Acad Child Adolesc Psychiatry 36:21–29
Bucholz KK (1999) Nosology and epidemiology of addictive disorders and their comorbidity. Psychiatr Clin North Am 22:221–240
Bukstein OG, Glancy LJ, Kaminer Y (1992) Patterns of affective comorbidity in a clinical population of dually diagnosed adolescent substance abusers. J Am Acad Child Adolesc Psychiatry 31:1041–1045
Clark DB, Parker AM, Lynch KG (1999) Psychopathology and substance-related problems during early adolescence: a survival analysis. J Clin Child Psychol 28:333–341
Clark DB, Pollock N, Bukstein OG, Mezzich AC, Bromberger JT, Donovan JE (1997) Gender and comorbid psychopathology in adolescents with alcohol dependence. J Am Acad Child Adolesc Psychiatry 36:1195–1203
Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A (2003) Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry 60:837–844
Cottler LB, Schuckit MA, Helzer JE, Crowley T, Woody G, Nathan P, Hughes J (1995) The DSM-IV field trial for substance use disorders: major results. Drug Alcohol Depend 38:59–69
Crowley TJ, Macdonald MJ, Whitmore EA, Mikulich SK (1998) Cannabis dependence, withdrawal, and reinforcing effects among adolescents with conduct symptoms and substance use disorders. Drug Alcohol Depend 50:27–37
Dakof GA (2000) Understanding Gender Differences in Adolescent Drug Abuse: Issues of Comorbidity and Family Functioning. J Psychoactive Drugs 32:25–32
Dennis ML (1998) Global appraisal of individual needs (GAIN) manual: administration, scoring and interpretation. Lighthouse Publications, Bloomington, IL
Deykin EY, Buka SL, Zeena TH (1992) Depressive illness among chemically dependent adolescents. J Am Psychiatry 149:1341–1347
Ferdinand RF, Blüm M, Verhulst FC (2001) Psychopathology in adolescence predicts substance use in young adulthood. Addiction 96:861–870
Fisckenscher A, Novins D (2003) Gender differences and conduct disorder among American Indian adolescents in substance abuse treatment. J Psychoactive Drugs 35:79–84
Flory K, Lynam DR (2003) The relation between attention deficit hyperactivity disorder and substance abuse: what role does conduct disorder play? Clin Child Fam Psychol Rev 6:1–16
Friedman AS, Utada A (1989) A method for diagnosing and planning the treatment of adolescent drug abusers: the Adolescent Drug Abuse Diagnosis (ADAD) instrument. J Drug Educ 19:285–312
de Graaf R, Bijl RV, Ten Have M, Beekman AT, Vollebergh WA (2004) Pathways to comorbidity: the transition of pure mood, anxiety and substance use disorders into comorbid conditions in a longitudinal population-based study. J Affect Disord 82:461–467
Grella C.E. Hser YI, Joshi V, et al. (2001) Drug treatment outcomes for adolescents with comorbid mental and substance use disorders. J Nerv Ment Dis 198:384–392
Grilo CM, Becker DF, Fehon DC, Edell WS, McGlashan (1996) Conduct disorder, substance use disorders, and coexisting conduct and substance use disorders in adolescent inpatients. Am J Psychiatry 153:914–920
Hannesdóttir H, Tyrfingsson T, Piha J (2001) Psychosocial functioning and psychiatric comorbidity among substance-abusing Icelandic adolescents. Nord J Psychiatry 55:43–48
Harrison PA, Fulkerson JA, Beebe TJ (1998) DSM-IV substance use disorder criteria for adolescents: a critical examination based on a statewide school survey. Am J Psychiatry 155:486–492
Hicks BM, Krueger RF, Iacono WG, McGue M, Patrick CJ (2004) Family Transmission and Heritability of Externalizing Disorders: A Twin Study. Arch Gen Psychiatry 60:922–928
Hovens JGFM, Cantwell DP, Kiriakos R (1994) Psychiatric comorbidity in hospitalized adolescent substance abusers. J Am Acad Child Adolesc Psychiatry 33:476–483
Jainchill N, De Leon G, Yagelka J (1997) Ethnic differences in psychiatric disorders among adolescent substance abusers in treatment. J Psychopath Behav Assessment 19:133–148
Khantzian E (1997) The self-medication hypothesis of substance use disorders: a reconsideration and recent applications. Harv Rev Psychiatry 4:231–244
Kaufman J, Birmaher B, Brent D, et al. (1997) Schedule for affective disorders and schizophrenia for school-age children present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 36:980–988
Kelly TM, Cornelius JR, Clark DB (2004) Psychiatric disorders and attempted suicide among adolescents with substance use disorders. Drug and Alcohol Depend 73:87–97
Kessler RC (2004) The epidemiology of dual diagnosis. Biol Psychiatry 56:730–737
King RD, Gaines LS, Lambert EW, Summerfelt WT, Bickman L (2000) The co-occurrence of psychiatric and substance use diagnosis in adolescents in different service systems: frequency, recognistion, cost, and outcome. J Behav Health Serv Res 27:417–430
Kranzler HR, Tinsley JA (eds.) (2004) Dual Diagnosis and Psychiatric Treatment: Substance Abuse and Comorbid Disorders. Marcel Dekker Inc., New York
Lucas CP, Zhang H, Fisher PW, et al. (2001) The DISC predictive scales (DPS): efficiently screening for diagnoses. J Am Acad Child adolesc Psychiatry 40:443–449
Martino S, Grilo CM, Fehon DC (2002) Development of the drug abuse Screening test for adolescents (DAST-A). Addict Behav 25:57–70
McLellan AT, Meyers K (2004) Contemporary addiction treatment: a review of systems problems for adults and adolescents. Biol Psychiatry 56:764–770
Molina BSG, Bukstein OG, Lynch KG (2002) Attention-deficit/hyperactivity disorder and conduct disorder symptomatology in adolescents with alcohol use disorders. Psychol Addict Behav 16:161–164
Myers MG, Stewart DG, Brown SA (1998) Progression from conduct disorder to antisocial personality disorder following treatment for adolescent substance abuse. Am J Psychiatry 155:479–485
Pandina RJ, Johnson V, Labouvie EW (1992) Affectivity: A central mechanism in the development of drug dependence. In: Glantz M, Pickens R (eds) Vulnerability to Drug Abuse. American Psychological Association, Washington, DC, pp 179–209
Rassool GH (2002) Dual diagnosis. substance misuse and psychiatric disorders. Blackwell Science, Oxford
Renner JA, Jr. (2004) How to train residents to identify and treat dual diagnosis patients. Biol Psychiatry 56:810–816
Robbins MS, Kumar S, Walker-Barnes C, et al. (2002) Ethnic differences in comorbidity among abusing adolescents referred to outpatient therapy. J Am Acad Child Adolesc Psychiatry 41:394–401
Roberts N, Vargo B, Ferguson HB (1989) Measurement of anxiety and depression in children and adolescents. Psychiatr Clin North Am 12:837–860
Rowe CL, Liddle HA, Greenbaum PE, Henderson CE (2004) Impact of psychiatric comorbidity on treatment of adolescent drug abusers. J Subst Abuse Treat 26:129–140
Rounds-Bryant JL, Kristiansen PL, Hubbard RL (1999) Drug abuse treatment outcome study of adolescents: a comparison of client characteristics and pretreatment behaviors in three treatment modalities. Am J Drug Alcohol Abuse 25:573–591
Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH diagnostic interview schedule for children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. J Am Acad Child Adolesc Psychiatry 39:28–38
Shaffer D, Fisher P, Dulcan M, et al. (1996) The NIMH diagnostic interview schedule for children version (DISC-2.3; description, acceptability, prevalence and performance in the MECA study). J Am Acad Child Adolesc psychiatry 35:865–877
Shaffer D, Schwab-Stone M, Fisher P, Cohen P, Piacentini J, Davies M, Conners CK, Regier D (1993) The Diagnostic Interview Schedule for Children-Revised Version (DISC-R): I. Preparation, field testing, interrater reliability, and acceptability. J Am Acad Child Adolesc Psychiatry 32:643–650
Shrier LA, Harris SK, Kurland M, Knight JR (2003) Substance use problems and associated psychiatric symptoms among adolescents in primary care. Pediatrics 111:e699–705
Spitzer R, Williams J, gibbon B (1987) Instruction manual for the structured clinical interview for DSM-III-R. State Psychiatric Institute, New York
Slaats-Willemse D, Swaab-Barneveld H, de Sonneville L, van der Meulen E, Buitelaar J (2003) Deficient response inhibition as a cognitive endophenotype of ADHD. J Am Acad Child Adolesc Psychiatry 42:1242–1248
Tarter RE, Kirisci L, Mezzich A, Cornelius JR, Pajer K, Vanyukov M, Gardner W, Blackson T, Clark D (2003) Neurobehavioral disinhibition in childhood predicts early age at onset of substance use disorder. Drug Alcohol Dep 73:121–132
Tarter R, Kirisci L, Mezzich A (1997) Multivariate typology of adolescents with alcohol use disorder. Am J Addic 6:150–158. Am J Psychiatry 160:1078–1085
Tims FM, Dennis ML, Hamilton N (2002) Characteristics and problems of 600 adolescent cannabis abusers in outpatient treatment. Addiction 97:46–57
Tomlinson KL, Brown SA, Abrantes A (2004) Psychiatric comorbidity and substance use treatment outcomes of adolescents. Psychol Addict Behav 18:160–169
Verhulst FC (2002) Inleiding in de kinder- en jeugdpsychiatrie. Koninklijke Van Gorcum b.v., Assen
Vreugdenhil C, Van Den Brink W, Wouters LF, Doreleijers TA (2003) Substance use, substance use disorders, and comorbidity patterns in a representative sample of incarcerated male Dutch adolescents. J Nerv Ment Dis 91:372–378
Weissman MM, Wolk S, Wickramaratne P, Goldstein RB, Adams P, Greenwald S, et al. (1999) Children with prepubertal-onset major depressive disorder and anxiety grown up. Arch Gen Psychiatry 56:794–801
White H, Xie M, Thompson W (2001) Psychopathology as a predictor of adolescent drug use trajectories. Psychol Addict Behav 15:210–218
Acknowledgements
The authors acknowledge the Stichting Kinder- & Jeugdpsychiatrie Oost-Nederland (SKJPON) for their generous support and the National Fund Mental Public Health (NFGV) for their grant (no. 5942).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Couwenbergh, C., van den Brink, W., Zwart, K. et al. Comorbid psychopathology in adolescents and young adults treated for substance use disorders. Eur Child Adolesc Psychiatry 15, 319–328 (2006). https://doi.org/10.1007/s00787-006-0535-6
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00787-006-0535-6