Abstract
This paper reports on the use of clonidine for the treatment of severe sleep problems associated with behavioural difficulties in children with neurodevelopmental disabilities. Data were obtained from reviewing the case notes of a series of six children with neurodevelopmental disorders of different nature and severity, presenting with problematic sleep. All children in this group showed maintained improvements in their sleep pattern following the use of clonidine with only mild side-effects reported.
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References
Camfield P, Gordon K, Dooley J, Camfield C (1996) Melatonin appears to be ineffective in children with intellectual deficits and fragmented sleep: six “n of 1” trials. J Child Neurol 11:341–343
Cantwell DP, Swanson J, Connor DF (1997) Clonidine use in children: clinical consideration of adverse responses. J Am Acad Child Adolesc Psychiatry 36:539–544
Chavin W, Tinson S (1980) Children with sleep difficulties. Health Visitor 53:477–480
Clements J, Wing L, Dunn G (1986) Sleep problems in handicapped children: a preliminary study. J Child Psychol Psychiatry 27(3):399–407
Connor DF, Fletcher KE, Swanson JM (1999) A meta-analysis of clonidine for symptoms of attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 38(12):1551–1559
Hoban T (2000) Sleeplessness in children with neurodevelopmental disorders. CNS Drugs 14(1):11–22
Hunt RD, Minderaa RB, Cohen DJ (1985) Clonidine benefits children with attention disorder and hyperactivity: report of a double-blind placebo crossover therapeutic trial. J Am Acad Child Adolesc Psychiatry 24:617–629
Hunt RD (1987) Treatment effects of oral and transdermal clonidine in relation to methylphenidate: an open pilot study in ADD-H. Psychopharmacol Bull 23:111–114
Jan JE, Espezel H, Appleton RE (1994) The treatment of sleep disorders with melatonin. Dev Med Child Neurol 36:97–107
Jan JE, Espezel H (1995) Melatonin treatment of chronic sleep disorders. Dev Med Child Neurol 37:279–280
Kahn A, Van de Merckt C, Rebuffat E, Morzin M, Scottiaux M, Blum D, Hennart P (1989) Sleep problems in healthy preadolescents. Paediatrics 84:542–546
Lancioni G, O’Reilly M, Basili G (1999) Review of strategies for treating sleep problems in persons with severe or profound mental retardation or multiple handicaps. Am J Ment Retardation 104 (2):170–186
Morrison DN, Mc Gee R, Stanton WR (1992) Sleep problems in adolescence. J Am Acad Child Adolesc Psychiatry 31:94–99
O’Callaghan FJK, et al. (1999) Use of melatonin to treat sleep disorders in tuberous sclerosis. Dev Med Child Neurol 41:123–126
Pillar G, Etzioni A, Shahar E, Lavie P (1998) Melatonin treatment in an institutionalized child with psychomotor retardation and an irregular sleep-wake pattern. Arch Dis Childhood 79:63–64
Prince JB, Wilens TE, Biederman J, Spencer TJ, Wozniak JR (1996) Clonidine for sleep disturbances associated with attention deficit hyperactivity disorder: a systematic chart review of 62 cases. J Am Acad Child Adolesc Psychiatry 35(5):599–605
Quine L (2001) Sleep problems in primary school children: comparison between mainstream and special school children. Child: care, health and development 27(3):201–221
Ramchandani P, Wiggs L, Webb V, Stores G (2000) A systematic review of treatment for settling problems and night waking in young children. Br Med J 320:209–213
Richman N (1981) A community survey of characteristics of 1–2 year olds with sleep disruption. J Am Acad Child Adolesc Psychiatry 20:281–291
Richman N (1981) Sleep problems in young children. Arch Dis Childhood 56:491–493
Richman N (1985) A double-blind drug trial of treatment in young children with waking problems. J Child Psychol Psychiatry 26:591–598
Rutter M, Tizard J, Whitmore K (1970) Education, health and behaviour. Longman. London
Sheldon SH (1998) Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet 351:1254
Stores G (1992) Annotation: sleep studies in children with a mental handicap. J Child Psychol Psychiatry 33:1303–1317
Stores G, Wiggs L (1998) Clinical services for sleep disorders. Arch Dis Childhood 79(6):495–497
Stores G, Wiggs L (2001) Sleep disorders in children and adolescents with disorders of development: its significance and management. Mac Keith Press. London
Turk J (2003) Melatonin supplementation for severe and intractable sleep disturbance in young people with genetically determined developmental disabilities: short review and commentary. J Med Genet 40:793–796
Wiggs L, Stores G (1996) Severe sleep disturbance and day time challenging behaviour in children with severe learning disabilities. J Intellect Disabil Res 40:518–528
Wiggs L, Stores G (1996) Sleep problems in children with severe intellectual disabilities: what help is being provided? J Appl Res Intellect Disabil 9(2):159–164
Wiggs L, Stores G (1998) Behavioural treatment for sleep problems in children with severe learning disabilities and challenging daytime behaviour: effect on sleep pattern of mother and child. J Sleep Res 7(2):119–126
Wiggs L (2001) Sleep problems in children with developmental disorders. J Royal Society Med 94:177–179
Wilens TE, Biederman J, Spencer T (1994) Clonidine for sleep disturbance associated with attention deficit hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 33(3):424–426
Zuckerman B, Stevenson J, Bailey V (1987) Sleep problems in early childhood: continuities, predictive factors, and behavioral correlates. Paediatrics 80(5):664–671
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Ingrassia, A., Turk, J. The use of clonidine for severe and intractable sleep problems in children with neurodevelopmental disorders. Europ.Child & Adolescent Psych 14, 34–40 (2005). https://doi.org/10.1007/s00787-005-0424-4
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DOI: https://doi.org/10.1007/s00787-005-0424-4