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MicroRNAs regulate bone metabolism

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Abstract

Osteoporosis is caused by an unbalance between bone formation and bone resorption. Bone homeostasis is regulated by intricate mechanisms. Recently, a novel class of regulatory factors termed microRNAs (miRNAs) has been found to play a crucial role in cell cycle control, apoptosis and other cellular processes including metabolism and differentiation. Published data have shown that some miRNAs regulate bone homeostasis, including bone formation, resorption, remodeling, repair and bone-related disease, by regulating the expression of certain cytokines and transcription factors. This review highlights the current knowledge of miRNAs and their involvement in the regulation of bone formation, bone resorption and the pathways regulating the progression of osteoporosis.

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All authors state that they have no conflicts of interest.

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Authors and Affiliations

  1. Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China

    Xin Zhao, Yi Li & Xiaodong Xie

  2. Department of Space Radiobiology, Institute of Modern Physics, Chinese Academy of Sciences, Lanzhou, 730000, China

    Dan Xu, Tingting Liu, Jufang Wang & Guangming Zhou

  3. Institution of Pathology, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China

    Jiangyan Zhang

  4. Gansu Hualing Biotechnology Research Center, Lanzhou, 730000, China

    Yinli Ji

Authors
  1. Xin Zhao
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  2. Dan Xu
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  3. Yi Li
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  4. Jiangyan Zhang
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  5. Tingting Liu
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  6. Yinli Ji
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  7. Jufang Wang
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  8. Guangming Zhou
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  9. Xiaodong Xie
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Corresponding authors

Correspondence to Guangming Zhou or Xiaodong Xie.

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Zhao, X., Xu, D., Li, Y. et al. MicroRNAs regulate bone metabolism. J Bone Miner Metab 32, 221–231 (2014). https://doi.org/10.1007/s00774-013-0537-7

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  • DOI: https://doi.org/10.1007/s00774-013-0537-7

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