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Which is the best technique for pancreaticoenteric reconstruction after pancreaticoduodenectomy? A critical analysis

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Abstract

The definitive surgical management of periampullary tumors is a challenging endeavor. This article reviews the available data on the efficacy of various methods of pancreaticoenteric reconstruction designed for the prevention of pancreatic fistula (PF). A literature search of the Medline database was used to identify randomized controlled trials (RCTs) that compared pancreaticojejunostomy (PJ) with pancreaticogastrostomy (PG) after pancreaticoduodenectomy (PD). A total of two metaanalyses and four prospective RCTs were identified. Individual RCTs comparing PJ and PG allow the surgeons participating in the trial to choose technical modifications of one particular technique. As a result, there is no universal agreement as to whether one particular variation is safer and less prone to PF than the others. In addition, the majority of RCTs failed to stratify patient risk of PF. Further studies are therefore necessary to define the optimal technique of pancreatic reconstruction after PD conducted in high-volume centers by high-volume surgeons.

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References

  1. Kawai M, Yamaue H. Analysis of clinical trials evaluating complications after pancreaticoduodenectomy: a new era of pancreatic surgery. Surg Today 2010;40:1011–1017.

    Article  PubMed  Google Scholar 

  2. Winter JW, Cameron JL, Campbell KA, Arnold MA, Chang DC, Coleman J, et al. 1423 Pancreaticoduodenectomies for pancreatic cancer: a single-institution experience. J Gastrointest Surg 2006;10:1199–1211.

    Article  PubMed  Google Scholar 

  3. Buchler MW, Friess H, Wagner M, et al. Pancreatic fistula after pancreatic head resection. Br J Surg 2000;87:883–889.

    Article  PubMed  CAS  Google Scholar 

  4. Mathur A, Pitt HA, Marine M, et al. Fatty pancreas: a factor in postoperative pancreatic fistula. Ann Surg 2007;246:1058–1064.

    Article  PubMed  Google Scholar 

  5. Pratt WB, Maithel SK, Vanounou T, et al. Clinical and economic validation of the International Study Group of Pancreatic Fistula (ISGPF) classification scheme. Ann Surg 2007;245:443–451.

    Article  PubMed  Google Scholar 

  6. Yeh TS, Jan YY, Jen LB, et al. Pancreaticojejunal anastomosis leak after pancreatoduodenectomy: multivariate analysis of perioperative risk factors. J Surg Res 1997;67:119–125.

    Article  PubMed  CAS  Google Scholar 

  7. Yang YM, Tiang XD, Zhuang Y, et al. Risk factor of pancreatic leakage after pancreticoduodenectomy. World J Gastroenterol 2005;11:2456–2461.

    PubMed  Google Scholar 

  8. Strasberg SM, McNevin MS. Results of a technique of pancreaticojejunostomy that optimizes blood supply to the pancreas. J Am Coll Surg 1998;187:591–596.

    Article  PubMed  CAS  Google Scholar 

  9. McKay A, Mackenzie S, Sutherland FR, et al. Meta-analysis of pancreaticojejunostomy versus pancreaticogastrostomy reconstruction after pancreaticoduodenectomy. Br J Surg 2006;93:929–936.

    Article  PubMed  CAS  Google Scholar 

  10. Wente N, Shrikhande SV, Müller MW, et al. Pancreaticojejunostomy versus pancreaticogastrostomy: systematic review and meta analysis. Am J Surg 2007;193:171–183.

    Article  PubMed  Google Scholar 

  11. Yeo CJ, Cameron JL, Maher MM, et al. A prospective randomized trial of pancreatogastrostomy or pancreatojejunostomy after pancreaticoduodenectomy. Ann Surg 1995;222:580–588.

    PubMed  CAS  Google Scholar 

  12. Bassi C, Falconi M, Molinari E, et al. Reconstruction by pancreaticojejunostomy versus pancreaticogastrostomy following pancreatectomy: results of a comparative study. Ann Surg 2005;242:767–771.

    Article  PubMed  Google Scholar 

  13. Duffas JP, Suc B, Msika S, et al. A controlled randomized multicenter trial of pancreatogastrostomy or pancreatojejunostomy after pancreaticoduodenectomy. Am J Surg 2005;189:720–729.

    Article  PubMed  Google Scholar 

  14. Fernández-Cruz L, Cosa R, Blanco L, et al. Pancreatogastrostomy with gastric partition after pylorus preserving pancreatoduodenectomy versus conventional pancreatojejunostomy: a prospective randomized study. Ann Surg 2008;248:930–938.

    Article  PubMed  Google Scholar 

  15. Tani M, Onishi H, Kinoshita H, et al. The evaluation of duct-tomucosa pancreaticojejunostomy in pancreaticoduodenectomy. World J Surg 2005;29:76–79.

    Article  PubMed  Google Scholar 

  16. Peng SY, Wang JW, Lau WY, et al. Conventional versus binding pancreaticojejunostomy after pancreaticoduodenectomy. A prospective randomized trial. Ann Surg 2007;245:692–698.

    Article  PubMed  Google Scholar 

  17. Bassi C, Falconi M, Molinari E, et al. Duct-to-mucosa versus endto-side pancreaticojejunostomy reconstruction after pancreaticoduodenectomy: results of a prospective randomized trial. Surgery 2003;134:766–771.

    Article  PubMed  Google Scholar 

  18. Berger AC, Howard TJ, Kennedy EP, et al. Does type of pancreaticojejunostomy after pancreaticoduodenectomy decrease rate of pancreatic fistula? A randomized, prospective, dual-institution trial. J Am Coll Surg 2009;208:738–749.

    Article  PubMed  Google Scholar 

  19. Winter JM, Cameron JL, Campbell KA, et al. Does pancreatic duct stenting decrease the rate of pancreatic fistula following pancreaticoduodenectomy? Results of a prospective randomized trial. J Gastrointest Surg 2006;10:1280–1290.

    Article  PubMed  Google Scholar 

  20. Poon RT, Fan ST, Loch M, et al. External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy. A prospective randomized trial. Ann Surg 2007;246:425–435.

    Article  PubMed  Google Scholar 

  21. Delcore R, Thomas JH, Pierce GE, et al. Pancreatogastrostomy: a safe drainage procedure after pancreatoduodenectomy. Surgery 1990;108:641–645.

    PubMed  CAS  Google Scholar 

  22. Aranha GV. A technique for pancreaticogastrostomy. Am J Surg 1998;175:328–329.

    Article  PubMed  CAS  Google Scholar 

  23. Aranha GV, Hodul P, Golts E, et al. A comparison of pancreaticogastrostomy and pancreaticojejunostomy following pancreaticoduodenectomy. J Gastrointest Surg 2003;7:672–682.

    Article  PubMed  Google Scholar 

  24. Telford GL, Mason GR. Pancreaticogastrostomy: clinical experience with a direct pancreatic-duct-to-gastric-mucosa anastomoses. Am J Surg 1984;147:832–837.

    Article  PubMed  CAS  Google Scholar 

  25. Ferguson DI, Wangensteen OH. Experimental anastomosis of the pancreatic duct. Ann Surg 1950;132:1066–1074.

    Article  PubMed  CAS  Google Scholar 

  26. Takao S, Shimazu H, Maenohara S, et al. Modified pancreaticogastrostomy following pancreaticoduodenectomy. Am J Surg 1993;165:317–321.

    Article  PubMed  CAS  Google Scholar 

  27. Connor S, Alexakis N, Garden OJ, Leandros E, Bramis J, Wigmore SJ. Meta-analysis of the value of somatostatin and its analogues in reducing complications associated with pancreatic surgery. Br J Surg 2005;92:1059–1067.

    Article  PubMed  CAS  Google Scholar 

  28. Zeng Q, Zhang Q, Han S, et al. Efficacy of somatostatin and its analogues in prevention of postoperative complications after pancreaticoduodenectomy. A meta-analysis of randomized controlled trials. Pancreas 2008;36:18–25.

    Article  PubMed  CAS  Google Scholar 

  29. Koti RS, Gurusamy KS, Fusai G, Davidson BR. Meta-analysis of randomized controlled trials on the effectiveness of somatostatin analogues for pancreatic surgery: a Cochrane review. HPB (Oxford) 2010;12:155–165.

    Google Scholar 

  30. Bassi C, Dervenis C, Butturini G, et al. International Study Group on Pancreatic Fistula Definition. Postoperative pancreatic fistula: an international study group (ISGPF) definition. Surgery 2005;138:8–13.

    Article  PubMed  Google Scholar 

  31. Kawai M, Tani M, Hirono S. How do we predict the clinically relevant pancreatic fistula after pancreaticoduodenectomy? An analysis in 244 consecutive patients. World J Surg 2009;33:2670–2678.

    Article  PubMed  Google Scholar 

  32. Watanabe M, Usui S, Kajiwara H, et al. Current pancreatogastrointestinal anastomotic methods: results of a Japanese survey of 3109 patients. J Hepatobiliary Pancreat Surg 2004; 11:25–33.

    Article  PubMed  Google Scholar 

  33. Ohwada S, Iwazaki S, Nakamura S, et al. Pancreaticojejunostomysecuring technique: duct-to-mucosa anastomosis by continuous running suture and parachuting using monofilament absorbable thread. J Am Coll Surg 185:190–194.

  34. Nakao A, Fernández-Cruz L. Pancreatic head resection with segmental duodenectomy. Safety and long-term results. Ann Surg 2007;246:923–931.

    Article  PubMed  Google Scholar 

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Fernández-Cruz, L., Belli, A., Acosta, M. et al. Which is the best technique for pancreaticoenteric reconstruction after pancreaticoduodenectomy? A critical analysis. Surg Today 41, 761–766 (2011). https://doi.org/10.1007/s00595-011-4515-1

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