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Erschienen in: Wiener klinische Wochenschrift 11-12/2021

23.09.2020 | original article

Association between psoriasis, psoriatic arthritis and gastrointestinal disease

An exploratory nationwide inpatient sample analysis

verfasst von: Ahmed Yousaf, BA, Rahul Raiker, BS, Stephen M. Davis, PhD, Swapna Gayam, MD, Zachary Zinn, MD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 11-12/2021

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Summary

Background

Psoriasis is associated with cardiovascular disease, inflammatory bowel disease (IBD), metabolic syndrome, and psychiatric disease. Furthermore, psoriasis is associated with immune dysregulation and systemic inflammation.

Objective

To determine the association of psoriasis and psoriatic arthritis with IBD and the association of the combination of psoriasis or psoriatic arthritis with IBD and other gastrointestinal illnesses.

Methods

Discharge data from the 2000–2014 Nationwide Inpatient Sample, Healthcare Cost and Utilization Project (HCUP), which approximates a 20% stratified sample of all US hospitalizations, were analyzed. Multivariable logistic regression was used to examine the association between psoriasis and psoriatic arthritis with IBD and 23 gastrointestinal illnesses adjusting for sociodemographic characteristics.

Results

Psoriasis was associated with IBD (Crohn’s disease adjusted odds ratio (aOR) = 2.13, 95% confidence interval (CI) [2.0–2.3], p < 0.001). When adjusting for sociodemographics and IBD, psoriasis was associated with 21 of 23 gastrointestinal diseases examined, most notably celiac disease, autoimmune hepatitis, and non-alcoholic fatty liver disease. Psoriatic arthritis was also associated with IBD (Crohn’s disease, aOR = 1.95, 95% CI [1.7–2.2], and ulcerative colitis, aOR = 2.66, 95% CI [2.4–2.9]).

Conclusion

Psoriasis and psoriatic arthritis inpatients have an associated increase in IBD and numerous other gastrointestinal illnesses.
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Metadaten
Titel
Association between psoriasis, psoriatic arthritis and gastrointestinal disease
An exploratory nationwide inpatient sample analysis
verfasst von
Ahmed Yousaf, BA
Rahul Raiker, BS
Stephen M. Davis, PhD
Swapna Gayam, MD
Zachary Zinn, MD
Publikationsdatum
23.09.2020
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 11-12/2021
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-020-01740-8

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