Skip to main content
Home
Zeitschriften
Zeitungen
Podcast
Gesundheitspolitik
Praxis
Allerlei
Jobs
Fachgebiete
Allgemeinmedizin Anästhesiologie & Intensivmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kinder & Jugendheilkunde Neurologie & Psychiatrie Orthopädie & Unfallchirurgie Pflege Urologie Zahnmedizin Apotheke
Subfächer Innere Medizin
Diabetologie Gastroenterologie Infektiologie Kardiologie Onkologie und Hämatologie Pneumologie Rheumatologie
Fortbildungen
Überblick Fortbildungen DFP-Literaturstudium-Artikel DFP-Webcast Fortbildungen DFP-Podcasts
Erweiterte Suche
Anmelden
nach oben
Wiener klinische Wochenschrift
Erschienen in: Wiener klinische Wochenschrift 21-22/2017

31.07.2017 | original article

Moderate alcohol consumption and atherosclerosis

Meta-analysis of effects on lipids and inflammation

verfasst von: Yunying Huang, Yongmei Li, Sichao Zheng, Xin Yang, Tenghua Wang, Jie Zeng

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 21-22/2017

Einloggen, um Zugang zu erhalten

Summary

Objective

Alcohol consumption plays an important role in the risk of major cardiovascular diseases. We conducted a meta-analysis to summarize the association between moderate alcohol consumption and atherosclerosis.

Design

In this study four databases and reference lists of retrieved articles were searched to identify eligible studies. A meta-analysis was carried out of all interventional studies that assessed the effects of moderate alcohol consumption on concentrations of low density lipoprotein cholesterol, high density lipoprotein cholesterol, triglycerides, apolipoprotein A I, interleukin 6, plasminogen activator inhibitor 1, fibrinogen, and other biomarkers previously found to be associated with risk of atherosclerosis.

Results

A total of 31 studies met the eligibility criteria. In response to moderate alcohol consumption, low density lipoprotein cholesterol decreased by 0.08 mmol/l (P = 0.05), and high density lipoprotein cholesterol increased by 0.08 mmol/l (P < 0.00001), whereas total cholesterol and triglyceride remained the same. Moreover, interleukin 6 decreased by 0.43 pg/ml (P = 0.03), whereas C‑reactive protein and tumor necrosis factor a remained the same. Several hemostatic factors and adiponectin were modestly affected by alcohol consumption.

Conclusion

Moderate alcohol consumption is causally related to lower risk of atherosclerosis through changes in lipid profiles and inflammation.
Vorheriger Artikel General practitioners in Styria – who is willing to take part in research projects and why?
Nächster Artikel Facial nerve palsy secondary to Epstein–Barr virus infection of the middle ear in pediatric population may be more common than we think
Literatur
1.
Rehm J, Shield KD, Roerecke M, Gmel G. Modelling the impact of alcohol consumption on cardiovascular disease mortality for comparative risk assessments: An overview. BMC Public Health. 2016;16:363.CrossRefPubMedPubMedCentral
2.
Muth ND, Laughlin GA, von Muhlen D, Smith SC, Barrett-Connor E. High-density lipoprotein subclasses are a potential intermediary between alcohol intake and reduced risk of cardiovascular disease: The Rancho Bernardo Study. Br J Nutr. 2010;104(7):1034–42.CrossRefPubMed
3.
Hannuksela ML, Liisanantti MK, Savolainen MJ. Effect of alcohol on lipids and lipoproteins in relation to atherosclerosis. Crit Rev Clin Lab Sci. 2002;39(3):225–83.CrossRefPubMed
4.
Chiva-Blanch G, Urpi-Sarda M, Llorach R, Rotches-Ribalta M, Guillen M, Casas R, et al. Differential effects of polyphenols and alcohol of red wine on the expression of adhesion molecules and inflammatory cytokines related to atherosclerosis: a randomized clinical trial. Am J Clin Nutr. 2012;95(2):326–34.CrossRefPubMed
5.
Alber HF, Suessenbacher A, Weidinger F. The role of inflammation in the pathophysiology of acute coronary syndromes. Wien Klin Wochenschr. 2005;117(13–14):445–55.CrossRefPubMed
6.
Onat A, Hergenc G, Dursunoglu D, Ordu S, Can G, Bulur S, et al. Associations of alcohol consumption with blood pressure, lipoproteins, and subclinical inflammation among Turks. Alcohol. 2008;42(7):593–601.CrossRefPubMed
7.
National Institute on Alcohol Abuse and Alcoholism. Health risks and benefits of alcohol consumption. Alcohol Res Health. 2000;24(1):5–11.
8.
9.
Begg CB, Mazumdar M. Operating characteristics of a rank correlation test for publication bias. Biometrics. 1994;50(4):1088–101.CrossRefPubMed
10.
Catapano AL, Graham I, De Backer G, Wiklund O, Chapman MJ, Drexel H, et al. ESC/EAS guidelines for the management of dyslipidaemias. Eur Heart J. 2016;37(39):2999–3058.CrossRefPubMed
11.
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation. 2002;105(9):1135–43.CrossRefPubMed
12.
Lau DC, Dhillon B, Yan H, Szmitko PE, Verma S. Adipokines: molecular links between obesity and atheroslcerosis. Am J Physiol Heart Circ Physiol. 2005;288(5):2031–41.CrossRef
13.
14.
Kontush A, Chapman MJ. Functionally defective high-density lipoprotein: A new therapeutic target at the crossroads of dyslipidemia, inflammation, and atherosclerosis. Pharmacol Rev. 2006;58(3):342–74.CrossRefPubMed
15.
16.
de Oliveira C, de Mattos AB, Silva CB, Mota JF, Zemdegs JC. Nutritional and hormonal modulation of adiponectin and its receptors adipoR1 and adipoR2. Vitam Horm. 2012;90:57–94.CrossRefPubMed
17.
18.
Arranz S, Chiva-Blanch G, Valderas-Martinez P, Medina-Remon A, Lamuela-Raventos RM, Estruch R. Wine, beer, alcohol and polyphenols on cardiovascular disease and cancer. Nutrients. 2012;4(7):759–81.CrossRefPubMedPubMedCentral
19.
O’Keefe JH, Bhatti SK, Bajwa A, DiNicolantonio JJ, Lavie CJ. Alcohol and cardiovascular health: the dose makes the poison … or the remedy. Mayo Clin Proc. 2014;89(3):382–93.CrossRefPubMed
20.
Djousse L, Himali JJ, Beiser A, Kelly-Hayes M, Wolf PA. Apolipoprotein e, alcohol consumption, and risk of ischemic stroke: the Framingham Heart Study revisited. J Stroke Cerebrovasc Dis. 2009;18(5):384–8.CrossRefPubMedPubMedCentral
21.
Imhof A, Koenig W. Alcohol inflammation and coronary heart disease. Addict Biol. 2003;8(3):271–7.CrossRefPubMed
22.
Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. Alcohol dosing and total mortality in men and women - An updated Meta-analysis of 34 prospective studies. Arch Intern Med. 2006;166(22):2437–45.CrossRefPubMed
23.
24.
Poli A, Marangoni F, Avogaro A, Barba G, Bellentani S, Bucci M, et al. Moderate alcohol use and health: A consensus document. Nutr Metab Cardiovasc Dis. 2013;23(6):487–504.CrossRefPubMed
25.
Barboriak JJ, Hogan WJ. Preprandial drinking and plasma lipids in man. Atherosclerosis. 1976;24(1–2):323–5.CrossRefPubMed
26.
Couzigou P, Fleury B, Crockett R, Rautou JJ, Blanchard P, Lemoine F, et al. High density lipoprotein cholesterol and apoprotein A1 in healthy volunteers during long-term moderate alcohol intake. Ann Nutr Metab. 1984;28(6):377–84.CrossRefPubMed
27.
Burr ML, Fehily AM, Butland BK, Bolton CH, Eastham RD. Alcohol and high-density-lipoprotein cholesterol: A randomized controlled trial. Br J Nutr. 1986;56(1):81–6.CrossRefPubMed
28.
Bertiere MC, Betoulle D, Apfelbaum M, Girard-Globa A. Time-course, magnitude and nature of the changes induced in HDL by moderate alcohol intake in young non-drinking males. Atherosclerosis. 1986;61(1):7–14.CrossRefPubMed
29.
Moore RD, Smith CR, Kwiterovich PO, Pearson TA. Effect of low-dose alcohol use versus abstention on apolipoproteins A‑I and B. Am J Med. 1988;84(5):884–90.CrossRefPubMed
30.
Valimaki M, Taskinen MR, Ylikahri R, Roine R, Kuusi T, Nikkila EA. Comparison of the effects of two different doses of alcohol on serum lipoproteins, HDL-subfractions and apolipoproteins A–I and A–II: a controlled study. Eur J Clin Invest. 1988;18(5):472–80.CrossRefPubMed
31.
Hagiage M, Marti C, Rigaud D, Senault C, Fumeron F, Apfelbaum M, et al. Effect of a moderate alcohol intake on the lipoproteins of normotriglyceridemic obese subjects compared with normoponderal controls. Metab Clin Exp. 1992;41(8):856–61.CrossRefPubMed
32.
Suzukawa M, Ishikawa T, Yoshida H, Hosoai K, Nishio E, Yamashita T, et al. Effects of alcohol consumption on antioxidant content and susceptibility of low-density lipoprotein to oxidative modification. J Am Coll Nutr. 1994;13(3):237–42.CrossRefPubMed
33.
Sharpe PC, McGrath LT, McClean E, Young IS, Archbold GP. Effect of red wine consumption on lipoprotein (a) and other risk factors for atherosclerosis. QJM. 1995;88(2):101–8.PubMed
34.
Clevidence BA, Reichman ME, Judd JT, Muesing RA, Schatzkin A, Schaefer EJ, et al. Effects of alcohol consumption on lipoproteins of premenopausal women. A controlled diet study. Arterioscler Thromb Vasc Biol. 1995;15(2):179–84.CrossRefPubMed
35.
McConnell MV, Vavouranakis I, Wu LL, Vaughan DE, Ridker PM. Effects of a single, daily alcoholic beverage on lipid and hemostatic markers of cardiovascular risk. Am J Cardiol. 1997;80(9):1226–8.CrossRefPubMed
36.
De Oliveira e Silva ER, Foster D, McGee Harper M, Seidman CE, Smith JD, Breslow JL, et al. Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A–I and A–II. Circulation. 2000;102(19):2347–52.CrossRefPubMed
37.
Mezzano D, Leighton F, Martinez C, Marshall G, Cuevas A, Castillo O, et al. Complementary effects of Mediterranean diet and moderate red wine intake on haemostatic cardiovascular risk factors. Eur J Clin Nutr. 2001;55(6):444–51.CrossRefPubMed
38.
Davies MJ, Baer DJ, Judd JT, Brown ED, Campbell WS, Taylor PR. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women: A randomized controlled trial. JAMA. 2002;287(19):2559–62.CrossRefPubMed
39.
Cartron E, Fouret G, Carbonneau MA, Lauret C, Michel F, Monnier L, et al. Red-wine beneficial long-term effect on lipids but not on antioxidant characteristics in plasma in a study comparing three types of wine – description of two O‑methylated derivatives of gallic acid in humans. Free Radic Res. 2003;37(9):1021–35.CrossRefPubMed
40.
Sierksma A, Vermunt SH, Lankhuizen IM, van der Gaag MS, Scheek LM, Grobbee DE, et al. Effect of moderate alcohol consumption on parameters of reverse cholesterol transport in postmenopausal women. Alcohol Clin Exp Res. 2004;28(4):662–6.
41.
Retterstol L, Berge KE, Braaten O, Eikvar L, Pedersen TR, Sandvik L. A daily glass of red wine: Does it affect markers of inflammation? Alcohol Alcohol. 2005;40(2):102–5.CrossRefPubMed
42.
Jensen T, Retterstol LJ, Sandset PM, Godal HC, Skjonsberg OH. A daily glass of red wine induces a prolonged reduction in plasma viscosity: A randomized controlled trial. Blood Coagulation Fibrinolysis. 2006;17(6):471–6.CrossRefPubMed
43.
Djurovic S, Berge KE, Birkenes B, Braaten O, Retterstol L. The effect of red wine on plasma leptin levels and vasoactive factors from adipose tissue: a randomized crossover trial. Alcohol Alcohol. 2007;42(6):525–8.CrossRefPubMed
44.
Romeo J, Warnberg J, Nova E, Diaz LE, Gonzalez-Gross M, Marcos A. Changes in the immune system after moderate beer consumption. Ann Nutr Metab. 2007;51(4):359–66.CrossRefPubMed
45.
Bantle AE, Thomas W, Bantle JP. Metabolic effects of alcohol in the form of wine in persons with type 2 diabetes mellitus. Metab Clin Exp. 2008;57(2):241–5.CrossRefPubMedPubMedCentral
46.
Imhof A, Blagieva R, Marx N, Koenig W. Drinking modulates monocyte migration in healthy subjects: a randomised intervention study of water, ethanol, red wine and beer with or without alcohol. Diabetes Vasc Dis Res. 2008;5(1):48–53.CrossRef
47.
Joosten MM, Beulens JW, Kersten S, Hendriks HF. Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: A randomised, crossover trial. Diabetologia. 2008;51(8):1375–81.CrossRefPubMedPubMedCentral
48.
Joosten MM, Witkamp RF, Hendriks HF. Alterations in total and high-molecular-weight adiponectin after 3 weeks of moderate alcohol consumption in premenopausal women. Metab Clin Exp. 2011;60(8):1058–63.CrossRefPubMed
49.
Joosten MM, van Erk MJ, Pellis L, Witkamp RF, Hendriks HF. Moderate alcohol consumption alters both leucocyte gene expression profiles and circulating proteins related to immune response and lipid metabolism in men. Br J Nutr. 2012;108(4):620–7.CrossRefPubMed
50.
Queipo-Ortuno MI, Boto-Ordonez M, Murri M, Gomez-Zumaquero JM, Clemente-Postigo M, Estruch R, et al. Influence of red wine polyphenols and ethanol on the gut microbiota ecology and biochemical biomarkers. Am J Clin Nutr. 2012;95(6):1323–34.CrossRefPubMed
51.
Zheng JS, Yang J, Huang T, Hu XJ, Luo M, Li D. Effects of Chinese liquors on cardiovascular disease risk factors in healthy young humans. TheScientificWorldJournal. 2012;2012:372143. doi:10.​1100/​2012/​372143
52.
Chiva-Blanch G, Urpi-Sarda M, Ros E, Valderas-Martinez P, Casas R, Arranz S, et al. Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: a randomized clinical trial. Clin Nutr. 2013;32(2):200–6.CrossRefPubMed
53.
Chiva-Blanch G, Magraner E, Condines X, Valderas-Martinez P, Roth I, Arranz S, et al. Effects of alcohol and polyphenols from beer on atherosclerotic biomarkers in high cardiovascular risk men: a randomized feeding trial. Nutr Metab Cardiovasc Dis. 2015;25(1):36–45.CrossRefPubMed
54.
Gepner Y, Golan R, Harman-Boehm I, Henkin Y, Schwarzfuchs D, Shelef I, et al. Effects of initiating moderate alcohol intake on Cardiometabolic risk in adults with type 2 diabetes: a 2‑year randomized, controlled trial. Ann Intern Med. 2015;163(8):569–79.CrossRefPubMed
Metadaten
Titel
Moderate alcohol consumption and atherosclerosis
Meta-analysis of effects on lipids and inflammation
verfasst von
Yunying Huang
Yongmei Li
Sichao Zheng
Xin Yang
Tenghua Wang
Jie Zeng
Publikationsdatum
31.07.2017
Verlag
Springer Vienna
Erschienen in
Wiener klinische Wochenschrift / Ausgabe 21-22/2017
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI
https://doi.org/10.1007/s00508-017-1235-6

Weitere Artikel der Ausgabe 21-22/2017

Wiener klinische Wochenschrift 21-22/2017 Zur Ausgabe

original article

Sex and gender matters

letter to the editors

Prevalence of vitamin D deficiency in otherwise healthy individuals between the ages of 18 and 90 years in southeast Turkey

original article

Patients’ view of routine follow-up after breast cancer treatment

original article

HPV prevalence in vulvar cancer in Austria

original article

Gender differences and the role of parental education, school types and migration on the body mass index of 2930 Austrian school children

MUW researcher of the month

MUW researcher of the month