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Wiener klinische Wochenschrift

Erschienen in:

01.03.2013 | letter to the editor

Duloxetine-induced life-threatening long QT syndrome

verfasst von: Matej Štuhec, PharmD

Erschienen in: Wiener klinische Wochenschrift | Ausgabe 5-6/2013

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Duloxetine hydrochloride (DH) is a potent inhibitor of norepinephrine and serotonin reuptake, with low impact on dopamine uptake. In patients unresponsive to selective serotonin reuptake inhibitors, the administration of DH and bupropion (BUP) is an effective switching strategy [1]. …

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Nächster Artikel MedUni Wien Researcher of the Month März 2013

Rosso G, Rigardetto S, Bogetto F, Maina G. A randomized, single-blind, comparison of duloxetine with bupropion in the treatment of SSRI-resistant major depression. J Affect Disorders. 2012;136:172–6.PubMedCrossRef

Hunziker ME, Suehs BT, Bettinger TL, Crismon ML. Duloxetine hydrochloride: a new dual-acting medication for the treatment of major depressive disorder. Clin Ther. 2005;27:1126–43.PubMedCrossRef

Zhang L, Chappell J, Gonzales CR, Small D, Knadler MP, Callaghan JT, et al. QT effects of duloxetine at supratherapeutic doses: a placebo and positive controlled study. J Cardiovasc Pharm. 2007;49:146–53.CrossRef

Drew BJ, Ackerman MJ, Funk M, et al. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol. 2010;55:934–47.PubMedCrossRef

Isbister GK, Balit CR. Bupropion overdose: QTc prolongation and its clinical significance. Ann Pharmacother. 2003;37:999–1002.PubMedCrossRef

Titel: Duloxetine-induced life-threatening long QT syndrome
verfasst von: Matej Štuhec, PharmD
Publikationsdatum: 01.03.2013
Verlag: Springer Vienna
Erschienen in: Wiener klinische Wochenschrift / Ausgabe 5-6/2013
Print ISSN: 0043-5325
Elektronische ISSN: 1613-7671
DOI: https://doi.org/10.1007/s00508-013-0330-6

Springer Medizin Österreich

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