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Risk factors for lymph node metastasis and long-term outcomes of patients with early gastric cancer after non-curative endoscopic submucosal dissection

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Abstract

Background

The long-term outcomes after non-curative gastric endoscopic submucosal dissection (ESD) are still unknown. We aimed to clarify the pathological risk factors for lymph node metastasis (LNM) of early gastric cancer (EGC) and the long-term outcomes among patients who were judged to have had non-curative ESD.

Methods

From September 2002 to December 2012, 506 patients who were judged to have had non-curative gastric ESD were enrolled and classified into two groups: (1) those who subsequently underwent additional surgical resection (surgical group, n = 323) and (2) those followed up without additional surgical resection (nonsurgical group, n = 183). We analyzed pathological risk factors for LNM of EGC in the surgical group. Additionally, we compared long-term outcomes in the two groups.

Results

LNM was found pathologically in 9.3 % of the surgical group (30/323) at the additional surgical resection after non-curative ESD. In the multivariate logistic regression analysis, lymphovascular invasion (LVI) was an independent risk factor for LNM in the surgical group (odds ratio 8.57, 95 % confidence interval 2.76–38.14, P < 0.0001). The 5-year cause-specific survival rate was similar in the surgical and nonsurgical groups (98.7 and 96.5 %, respectively; log-rank test, P = 0.07). In contrast, the 5-year cause-specific survival rate of patients with LVI in the surgical group was better than that in the nonsurgical group (98.2 and 79.1 %, respectively; log-rank test, P < 0.0001).

Conclusions

A detailed assessment of LVI is essential to the pathological evaluation of endoscopically resected specimens. An additional surgical resection should be strongly recommended for patients with LVI.

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Authors and Affiliations

  1. Division of Endoscopy, Shizuoka Cancer Center, 1007 Shimonagakubo, Nagaizumi, Sunto-gun, Shizuoka, 411-8777, Japan

    Noboru Kawata, Naomi Kakushima, Kohei Takizawa, Masaki Tanaka & Hiroyuki Ono

  2. Division of Gastric Surgery, Shizuoka Cancer Center, Shizuoka, Japan

    Rie Makuuchi, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura & Masanori Terashima

  3. Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan

    Takashi Sugino, Kimihide Kusafuka, Tadakazu Shimoda & Takashi Nakajima

Authors
  1. Noboru Kawata
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  2. Naomi Kakushima
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  3. Kohei Takizawa
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  4. Masaki Tanaka
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  9. Taiichi Kawamura
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  10. Takashi Sugino
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  11. Kimihide Kusafuka
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  12. Tadakazu Shimoda
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  13. Takashi Nakajima
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  14. Masanori Terashima
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  15. Hiroyuki Ono
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Corresponding author

Correspondence to Naomi Kakushima.

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Disclosures

N. Kawata, N. Kakushima, K. Takizawa, M. Tanaka, R. Makuuchi, M. Tokunaga, Y. Tanizawa, E. Bando, T. Kawamura, T. Sugino, K. Kusafuka, T. Shimoda, T. Nakajima, M. Terashima, and H. Ono have no conflict of interest or financial interests to declare in association with this study.

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Kawata, N., Kakushima, N., Takizawa, K. et al. Risk factors for lymph node metastasis and long-term outcomes of patients with early gastric cancer after non-curative endoscopic submucosal dissection. Surg Endosc 31, 1607–1616 (2017). https://doi.org/10.1007/s00464-016-5148-7

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  • DOI: https://doi.org/10.1007/s00464-016-5148-7

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