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Portomesenteric venous thrombosis following major colon and rectal surgery: incidence and risk factors

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Abstract

Background

Portomesenteric venous thrombosis (PMVT) is an uncommon complication of abdominal surgery. The objective of this study was to assess PMVT risk factor profiles and patient outcomes after colorectal surgery.

Methods

A single center retrospective review of patients undergoing colorectal surgery was performed (2007–2012). PMVT was defined as thrombus within the portal, splenic, or superior mesenteric vein on computed tomography (CT). Inferior mesenteric vein thrombosis was excluded. Independent samples t test was used to compare data variables between PMVT and non-PMVT patients. Univariate and multivariate logistic regression analyses were used to assess PMVT risk factors.

Results

There were 1,224 patients included (mean age 62 years, male = 566). Elective bowel resection was performed for colon carcinoma (n = 302), rectal carcinoma (n = 112), ulcerative colitis (n = 125), Crohn’s disease (n = 78), polyps (n = 117), and diverticulitis (n = 215). Patients undergoing gynecological resections and emergent laparotomies were included (n = 275). Thirty-six patients (3 %) were diagnosed with PMVT by CT: 17/36 on initial presentation and 19/36 by expert radiologist review. Patients with PMVT were younger (53 vs. 62 years, p = 0.001) with higher BMI (30.5 vs. 26.7, p < 0.001) and thrombocytosis (464 vs. 306, p < 0.001) compared to patients without PMVT. Univariate logistic regression identified younger age (p < 0.001), obesity (p < 0.001), ulcerative colitis (p < 0.001), thrombocytosis, (p < 0.001) and proctocolectomy as significant predictors of PMVT. Stepwise multivariate logistic regression identified that obesity (p < 0.001), thrombocytosis, (p < 0.001) and restorative proctocolectomy (p = 0.001) were still significant predictors. No patients in the PMVT group suffered bowel infarction and no related mortalities occurred. Thirty-day readmission rates were higher in the PMVT group (53 % vs. 17 %, p < 0.01).

Conclusion

BMI ≥ 30 kg/m2, thrombocytosis, and restorative proctocolectomy were significant predictors of PMVT. Initial diagnostic studies showed a PMVT rate of 1.4 %; however, after expert focused radiologic review, the actual rate was 3 %. Thus, the diagnosis of PMVT is difficult and readmission after colorectal surgery should prompt its consideration.

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Disclosures

Drs. Kristin A. Robinson, Mark E. O’Donnell, David Pearson, J. Scott Kriegshauser, Melanie Odeleye, Zachary Bodnar, and Kristen Kalkbrenner, PA-C, have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Divisions of Colorectal Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA

    David Pearson, Melanie Odeleye, Kristen Kalkbrenner, Zachary Bodnar & Tonia M. Young-Fadok

  2. Vascular and Endovascular Surgery, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA

    Mark E. O’Donnell

  3. Department of Radiology, Mayo Clinic, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA

    Kristin A. Robinson & J. Scott Kriegshauser

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  1. Kristin A. Robinson
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Correspondence to Kristin A. Robinson.

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Robinson, K.A., O’Donnell, M.E., Pearson, D. et al. Portomesenteric venous thrombosis following major colon and rectal surgery: incidence and risk factors. Surg Endosc 29, 1071–1079 (2015). https://doi.org/10.1007/s00464-014-3788-z

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  • DOI: https://doi.org/10.1007/s00464-014-3788-z

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