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SLEEVEPASS: A randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results

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Abstract

Background

The long-term efficacy of laparoscopic Roux-en-Y gastric bypass (RYGB) in the treatment of morbid obesity has been demonstrated. Laparoscopic sleeve gastrectomy (SG) as a single procedure has shown promising short-term results, but the long-term efficacy of SG has not yet been demonstrated. The aim of this study was to determine the preliminary 30-day morbidity and mortality of RYGB and SG in a prospective multicenter randomized setting.

Methods

A total of 240 morbidly obese (BMI = 35–66 kg/m²) patients evaluated by a multidisciplinary team were randomized to undergo either RYGB or SG. There were 117 patients in the RYGB group and 121 in the SG group; two patients had to be excluded after randomization. Both study groups were comparable regarding age, gender, BMI, and comorbidities.

Results

There was no 30-day mortality. The median operating time was significantly shorter in the SG group (66 min vs. 94 min, p < 0.001). All complications were recorded thoroughly. There were 7 (5.8 %) major complications following SG and 11 (9.4 %) after RYGB (p = 0.292). Nine (7.4 %) SG patients and 20 (17.1 %) RYGB patients had minor complications (p = 0.023). The overall morbidity was 13.2 % after SG and 26.5 % after RYGB (p = 0.010). There were three (2.5 %) early reoperations after SG and four (3.3 %) after RYGB (p = 0.719).

Conclusions

At 30-day analysis SG is associated with a shorter operating time and fewer early minor complications compared to RYGB. There were no significant differences in major complications or early reoperations. Long-term follow-up is required to determine the effect on weight loss, resolution of obesity-related comorbidities, and improvement of quality of life.

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Acknowledgments

Orion-Farmos Research Foundation grant, Turku University Hospital research grant and Vaasa Central Hospital research grant.

Disclosures

Drs. M. Helmiö, L. Victorzon, J. Ovaska, M. Leivonen, A. Juuti, N. Jaser, P. Peromaa, P. Tolonen, S. Hurme, and P. Salminen have no conflicts of interest or financial ties to disclose.

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Authors and Affiliations

  1. Department of Surgery, Turku University Hospital, PL 52, 20521, Turku, Finland

    Mika Helmiö, Jari Ovaska & Paulina Salminen

  2. Department of Emergency, Turku University Hospital, Turku, Finland

    Paulina Salminen

  3. Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland

    Marja Leivonen, Anne Juuti & Nabil Jaser

  4. Department of Surgery, Vaasa Central Hospital, Vaasa, Finland

    Mikael Victorzon, Pipsa Peromaa & Pekka Tolonen

  5. Department of Surgery, Hatanpää Hospital, Tampere, Finland

    Pipsa Peromaa

  6. Department of Biostatistics, University of Turku, Turku, Finland

    Saija Hurme

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  1. Mika Helmiö
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  2. Mikael Victorzon
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  3. Jari Ovaska
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  4. Marja Leivonen
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  5. Anne Juuti
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  6. Nabil Jaser
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  7. Pipsa Peromaa
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  8. Pekka Tolonen
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  9. Saija Hurme
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  10. Paulina Salminen
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Correspondence to Mika Helmiö.

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Helmiö, M., Victorzon, M., Ovaska, J. et al. SLEEVEPASS: A randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results. Surg Endosc 26, 2521–2526 (2012). https://doi.org/10.1007/s00464-012-2225-4

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  • DOI: https://doi.org/10.1007/s00464-012-2225-4

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