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A critical appraisal of the hemodynamic signal driving liver regeneration

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Abstract

Background

Many aspects of the signaling mechanisms involved in the initiation of hepatic regeneration are under current investigation. Nevertheless, the actual mechanisms switching liver regeneration on and off are still unknown. Hemodynamic changes in the liver following partial hepatectomy have been suggested to be a primary stimulus in triggering liver regeneration. Most of the new knowledge about the impact of hemodynamic changes on liver regeneration is both conceptually important and directly relevant to clinical problems.

Purpose

The purpose of this review is therefore to exclusively address the hemodynamic signal driving the liver regeneration process.

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Acknowledgment

The authors kindly thank Anja Gellert (Institute for Experimental Surgery) for assistance in designing the figures.

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  1. Institute for Experimental Surgery, University of Rostock, 18055, Rostock, Germany

    Kerstin Abshagen, Christian Eipel & Brigitte Vollmar

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  1. Kerstin Abshagen
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  2. Christian Eipel
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  3. Brigitte Vollmar
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Correspondence to Kerstin Abshagen.

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Abshagen, K., Eipel, C. & Vollmar, B. A critical appraisal of the hemodynamic signal driving liver regeneration. Langenbecks Arch Surg 397, 579–590 (2012). https://doi.org/10.1007/s00423-012-0913-0

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  • DOI: https://doi.org/10.1007/s00423-012-0913-0

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