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Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the three-dimensional choroidal vascularity index (CVI) in the eyes with treatment-naïve acute central serous chorioretinopathy (CSC) using swept-source optical coherence tomography (SS OCT).

Methods

In this prospective cross-sectional study, OCT and OCT angiography covered an area of 12 × 12 mm centered on the fovea. Three-dimensional CVI was defined as the ratio of the choroidal vascular luminal volume to the total choroidal volume. The location of pigment epithelial detachment (PED) and the area with abnormal perfusion at choriocapillary layer were compared with the distribution of the three-dimensional CVI.

Results

Thirty-two eyes with treatment-naïve acute CSC, 18 fellow eyes, and 48 control eyes were enrolled. Three-dimensional CVI had good repeatability on control eyes, with a coefficient of variation of 0.166. The mean CVI in the scan area was 0.35 in the eyes with CSC, 0.34 in the fellow eyes of CSC, and 0.30 in the control eyes. The overall CVI in the control eyes was significantly lower than that in the eyes with CSC and that in fellow eyes (P < 0.001 and P = 0.006, respectively). The eyes with CSC and the fellow eyes had significantly higher CVI values at the posterior pole and the drainage routes of choroidal veins. In the eyes with CSC, PEDs and choriocapillary with abnormal perfusion colocalized with the dilated choroidal vessels, which had high three-dimensional CVI values.

Conclusion

Increased three-dimensional CVI suggested an increased vascular component in the eyes with CSC and in fellow eyes. The three-dimensional CVI is a useful imaging marker of choroidal diseases that volumetrically assesses the choroidal vasculature and might advance our understanding of CSC pathophysiology.

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Acknowledgments

Thanks are due to Cheng Yan, Hongxia Chang, Jiayin Wang, and Shan Wu for collecting data and supporting this study.

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Authors and Affiliations

  1. Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, 100730, China

    Jingyuan Yang, Erqian Wang, Mingzhen Yuan & Youxin Chen

  2. Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing, China

    Jingyuan Yang, Erqian Wang, Mingzhen Yuan & Youxin Chen

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  1. Jingyuan Yang
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Correspondence to Youxin Chen.

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The authors declare that they have no conflict of interest.

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All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Supplementary Fig.

Coefficient of variation of the choroidal vascularity index (CVI) in 12 × 12 mm girds in control eyes and fellow eyes of central serous chorioretinopathy. The left halves of these tables had relatively less CVI values. (PNG 1142 kb)

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Yang, J., Wang, E., Yuan, M. et al. Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 258, 241–247 (2020). https://doi.org/10.1007/s00417-019-04524-7

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  • DOI: https://doi.org/10.1007/s00417-019-04524-7

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