Skip to main content
Log in

Titanium back plate for a PMMA keratoprosthesis: clinical outcomes

  • Cornea
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

    We’re sorry, something doesn't seem to be working properly.

    Please try refreshing the page. If that doesn't work, please contact support so we can address the problem.

Abstract

Background/Purpose

To compare the rate of retroprosthetic membrane (RPM) formation in Boston Keratoprosthesis (BKPro) with polymethyl methacrylate (PMMA) versus titanium backplates.

Design

Retrospective comparative chart review.

Methods

Multicenter study population: a total of 78 eyes with keratoprosthesis implants with either PMMA or titanium backplates were included in the study. To be included in the study, all subjects had to have completed a minimum of 6-month follow-up period. Incidence of RPM development at 6-month postoperative period was noted across the study population. PMMA and titanium backplates were then compared by their rate of association with subsequent RPM.

Results

Twenty-three out of 55 eyes (41.8%) with PMMA backplates and three out of 23 eyes (13.0%) with titanium backplates had developed an RPM at 6 months after implantation. The titanium backplates were associated with significantly less RPM formation than PMMA backplates (p = 0.014, Chi-square test).

Conclusions

Titanium seems to be associated with less RPM formation than PMMA when used as a material for the BKPro back plate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Dohlman CH, Harissi-Dagher M, Khan BF, Sippel KC, Aquavella JV, Graney JM (2006) Introduction to the use of the Boston Keratoprosthesis. Expert Rev Ophthalmol 1:41–48

    Article  Google Scholar 

  2. Stone W Jr, Herbert E (1953) Experimental study of plastic material as replacement for the cornea. Am J Ophthalmol 36:168–173

    PubMed  Google Scholar 

  3. Wong JY, Bronzino JD (2007) Biomaterials. CRC Press, Boca Raton

    Book  Google Scholar 

  4. Niinomi M (2008) Metallic biomaterials. J Artif Organs 11:105–110

    Article  PubMed  CAS  Google Scholar 

  5. Moroz ZI (1987) Artificial cornea. In: Fyodorov SN (ed) Microsurgery of the eye: main aspect. Mir, Moscow, p 27

    Google Scholar 

  6. Linnola RJ, Happonen AP, Andersson OH, Vedel E, Yli-Urpa AU, Krause U, Laatikainen L (1996) Titanium and bioactive glass-ceramic coated titanium as materials for keratoprosthesis. Exp Eye Res 63:471–478

    Article  PubMed  CAS  Google Scholar 

  7. Ament JD, Spurr-Michaud S, Dohlman CH, Gipson IK (2009) The Boston Keratoprosthesis: comparing corneal cell compatibility with titanium and PMMA back plates. Cornea 28:808–811

    Article  PubMed  Google Scholar 

  8. Dohlman CH, Todani A, Ament JD, Chodosh J, Ciolino JB, Colby KA, Pineda R, Belin MW, Aquavella JV, Graney J (2009) Titanium vs PMMA back plates for Boston keratoprosthesis: Incidence of retroprosthetic membrane. IOVS; ARVO poster #1505

  9. Dohlman CH, Harissi-Dagher M, Graney JM (2007) The Boston Keratoprosthesis: a new threadless design. D J Ophthalmol 13:3

    Google Scholar 

  10. Todani A, Gupta P, Colby K (2009) Type I Boston Keratoprosthesis with cataract extraction and intraocular lens placement for visual rehabilitation of herpes zoster ophthalmicus: the "KPro Triple". Br J Ophthalmol 93:119

    Article  PubMed  CAS  Google Scholar 

  11. Dohlman CH, Nouri M (2005) Keratoprosthesis surgery. In: Foster CS, Azar D, Dohlman CH (eds) Smolin and Thoft’s the cornea, 4th edn. Lippincott Williams and Wilkins, Philadelphia, pp 1085–1095

    Google Scholar 

  12. Chew HF, Ayres BD, Hammersmith KM, Rapuano CJ, Laibson PR, Myers JS, Jin YP, Cohen EJ (2009) Boston Keratoprosthesis outcomes and complications. Cornea 28:989–996

    Article  PubMed  Google Scholar 

Download references

Acknowledgement

Study was supported by the Keratoprosthesis Fund, Massachusetts Eye and Ear Infirmary.

Conflicts of interest

All authors are full time employees of their listed institutes and otherwise have no financial interest in any companies or products mentioned in the article. Study approved by Institutional Review Board Committees of the individual institutions. Performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Claes H. Dohlman.

Electronic supplementary material

Below is the link to the electronic supplementary material.

ESM 1

(DOC 27 kb)

Rights and permissions

Reprints and permissions

About this article

Cite this article

Todani, A., Ciolino, J.B., Ament, J.D. et al. Titanium back plate for a PMMA keratoprosthesis: clinical outcomes. Graefes Arch Clin Exp Ophthalmol 249, 1515–1518 (2011). https://doi.org/10.1007/s00417-011-1684-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-011-1684-y

Keywords

Navigation